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WilhelmssonLabChalmers

@wilhelmssonlab.bsky.social
33 followers 44 following 8 posts

Fluorescence, RNA, DNA, RNA therapeutics, spectroscopy, microscopy, optical tweezers, nucleic acid conformation and dynamics

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WilhelmssonLabChalmers @wilhelmssonlab.bsky.social · 18/06/2026
Really happy to share the outcome of a collaborative effort that was just published in Nature Methods. Thanks go to the Volpe lab for pioneering and leading this work. www.nature.com/articles/s41...
nature.com
SmartTrap: automated precision experiments with optical tweezers - Nature Methods
SmartTrap is a smart optical tweezers platform that integrates real-time three-dimensional particle tracking, electronics and microfluidics to perform single-molecule biophysics and cell mechanics exp...
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WilhelmssonLabChalmers @wilhelmssonlab.bsky.social · 11/03/2026
Happy and proud to now see this study from our lab published. www.nature.com/articles/s41...
nature.com
Increased brightness of fluorescent uridine, qU, inside single- and double-stranded RNA - Scientific Reports
Scientific Reports - Increased brightness of fluorescent uridine, qU, inside single- and double-stranded RNA
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WilhelmssonLabChalmers @wilhelmssonlab.bsky.social · 17/11/2025
Happy to share that we have a paper out in JBC. Here we develop an adenine analogue for in vitro transcription fluorescence labeling. The labeled mRNA can then be used for cell uptake studies and protein expression. Great job by all co-authors! www.sciencedirect.com/science/arti...
kwnsfk27.r.eu-west-1.awstrack.me
Redirecting
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WilhelmssonLabChalmers @wilhelmssonlab.bsky.social · 06/10/2025
First meeting with all doctoral students in our EU project @mechanism-network.bsky.social in Cologne at Stephanie Kath-Schorr's dept @kathlab.bsky.social this week. Coordinator Fredrik Westerlund @westerlundlab.bsky.social kicking it off. Great to meet all!
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WilhelmssonLabChalmers @wilhelmssonlab.bsky.social · 22/08/2025
Accepted article published online today. Great work by Pauline Pfeiffer and the rest of the team! Here we follow nucleotides and cellular RNA inside live cells by metabolic labelling and FLIM. pubs.rsc.org/en/Content/A...
pubs.rsc.org
Monitoring Nucleoside Metabolism in Living Cells with a Nucleobase Analogue via Fluorescence Lifetime Imaging
To overcome challenges in fluorescence labelling of RNA inside living cells we have recently introduced a direct approach using the fluorescent nucleobase analogue 2CNqA. Here we demonstrate its poten...
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WilhelmssonLabChalmers @wilhelmssonlab.bsky.social · 20/08/2025
So incredibly happy for and proud of my PhD student Pauline Pfeiffer who got her PhD thesis printed today! What a book! PhD defense on September 12.
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Reposted by WilhelmssonLabChalmers
MeChaNiSM Doctoral Network @mechanism-network.bsky.social · 11/08/2025
Marcus Wilhelmsson is Professor at Chalmers University of Technology, working with nucleobase modifications, for example, for fluorescence labeling. He will host one student who develops novel nucleobase analogues that will facilitate single-molecule biophysics studies. @wilhelmssonlab.bsky.social
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Reposted by WilhelmssonLabChalmers
MeChaNiSM Doctoral Network @mechanism-network.bsky.social · 23/06/2025
Erwin Peterman is a professor at VU University Amsterdam and an expert on combining fluorescence with optical tweezers. He will host 1 student within MeChaNiSM, who will study novel fluorescently modified nucleic acids, including base analogs with these tools. www.nat.vu.nl/~erwinp
nat.vu.nl
Erwin Peterman: Home
Professor Physics of Living Systems; Photo Credit: Patrick Siemons)
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Reposted by WilhelmssonLabChalmers
MeChaNiSM Doctoral Network @mechanism-network.bsky.social · 17/06/2025
Jocelyne Vreede is a professor at University of Amsterdam, using molecular simulation to study nucleic acids in atomistic detail. She will host 2 students within MeChaNiSM to characterise how modified bases and small molecules affect nucleic acid structure and dynamics. @vreedecompchem.bsky.social
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WilhelmssonLabChalmers @wilhelmssonlab.bsky.social · 10/05/2025
Our lab is happy to be part of EU doctoral network MeChaNiSM www.chalmers.se/en/projects/.... Glad to have the PhD students at Chalmers in place and looking forward to full speed ahead in the project.
chalmers.se
MeChaNiSM
Mechanical Characterization of Nucleic acids using Single Molecule techniques
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