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weigangcui.bsky.social

@weigangcui.bsky.social
23 followers 28 following 15 posts

Assistant Professor @ Changping Lab. Neuroimaging, brain function, brain-computer interface

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weigangcui.bsky.social @weigangcui.bsky.social · 22/05/2026
4/5 Validation on task activation data, which provides an a priori reference for evaluating its outputs. It recovers convincing maps — and goes further, resolving fine-grained differences across working memory tasks.
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weigangcui.bsky.social @weigangcui.bsky.social · 22/05/2026
3/5 Validation on lesion datasets. Whether a symptom has a true functional basis or not, rLNM can distinguish it reliably. More importantly, it reveals both cross-symptom maps and symptom-specific networks across related conditions (motor/visual anosognosia).
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weigangcui.bsky.social @weigangcui.bsky.social · 22/05/2026
2/5 How does rLNM work? For sensitivity, we move beyond arbitrary thresholds and use an anatomy-preserving spatial null model to control false positives/negatives. For specificity, we regress out cross-symptom effects to reveal cleaner, symptom-specific networks.
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weigangcui.bsky.social @weigangcui.bsky.social · 22/05/2026
Lesion network mapping (LNM) links symptoms to brain circuits, but isolating symptom-specific effects remains challenging. We introduce robust LNM, a unified framework to reveal reliable, symptom-specific networks. biorxiv.org/content/10.64898/2026.05.18.725812v2
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weigangcui.bsky.social @weigangcui.bsky.social · 06/01/2026
5/6 Expressions of the acetylcholine, serotonin and dopamine transporters overlap with the glioma network, consistent with recent advances in cancer neuroscience.
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weigangcui.bsky.social @weigangcui.bsky.social · 06/01/2026
4/6 If the AMN is a functional substrate of gliomas, is there any relationship between tumor location and patient survival? We found that patients with gliomas invading more AMN regions exhibited significantly shorter overall survival.
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weigangcui.bsky.social @weigangcui.bsky.social · 06/01/2026
3/6 In addition to common cerebral gliomas, we tried to predict the locations of multifocal and cerebellar gliomas by the AMN: ~90% localized within the network, and notably, no glioma was found entirely outside it.
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weigangcui.bsky.social @weigangcui.bsky.social · 06/01/2026
2/6 Aggregating glioma network maps across all patients, we showed that this network consistently aligns with the AMN spanning cerebral cortex, subcortex, and cerebellum.
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weigangcui.bsky.social @weigangcui.bsky.social · 06/01/2026
1/6 We analyzed 3 large independent neuroimaging cohorts (1000+ glioma patients) and used lesion network mapping to show: gliomas are anatomically diverse but converge onto a reproducible functional network.
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weigangcui.bsky.social @weigangcui.bsky.social · 06/01/2026
Check out our new work on the relationship between glioma and system-level functional networks! We identify that nearly all gliomas localize within a common brain functional network, Action-Mode Network (AMN) . biorxiv.org/content/10.64898/2026.01.05.697608v1
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