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Victor Klein-Sousa

@vkleinsousa.bsky.social
53 followers 74 following 14 posts

PhD Fellow @cphbiosciphd @NMITaylorLab @UCPH_CPR 🇩🇰 | Structural biology 🤝 phages 🔬 🇧🇷 (he/him)

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Victor Klein-Sousa @vkleinsousa.bsky.social · 16/09/2026
I'm happy to share one of my favorite projects from the past 4 years. 'Piercing mechanism in the minimal contractile tail of bacteriophage P2'. In this preprint, we applied #cryo-EM, #cryo-ET, TEM, and #computationalbiology to study the #phage P2 virion structure and its contraction mechanism.
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Aritz Roa-Eguiara @aritz-roa.bsky.social · 07/03/2026
🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process. www.biorxiv.org/content/10.6...
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Victor Klein-Sousa @vkleinsousa.bsky.social · 13/06/2025
Had a fantastic time at the first Danish Viruses of Microbes meeting! Great to see all the cutting-edge phage research in the Nordics. Honored to present RBPseg + the #tailfiber structural atlas. Thanks for the great questions & feedback! #DKVoM25 #Phages
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cryoEM papers @cryoempapers.bsky.social · 07/06/2025
RBPseg: Toward a complete phage tail fiber structure atlas pubmed.ncbi.nlm.nih.gov/40479047/ #cryoEM
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Victor Klein-Sousa @vkleinsousa.bsky.social · 10/06/2025
Excited to see our work published in @ScienceAdvances ! We present RBPseg, a method for structural prediction of #phage receptor-binding proteins. We applied it to diverse tail fibers and validated the predicted structures using #cryoEM. Read here: www.science.org/doi/10.1126/...
science.org
RBPseg: Toward a complete phage tail fiber structure atlas
RBPseg enables accurate modeling of tail fiber structure, providing the first comprehensive tail fiber structure atlas.
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Rafal Mostowy @rafalmostowy.bsky.social · 20/05/2025
I'm looking for a postdoc in computational evolutionary phage genomics, with the goal to better understand how protein innovation arises in viruses, at @jagiellonskiuni.bsky.social in Krakow (Poland). Drop me a line if it sounds cool! Deadline: 20.06. Link here: mcb.uj.edu.pl/documents/15...
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Victor Klein-Sousa @vkleinsousa.bsky.social · 19/05/2025
I’ve been exploring interactive networks to visualize #protein structure contacts — super helpful for large viral complexes. I put everything together in a Google Colab in case it helps others too. Here’s how it looks for the phage T4 baseplate:
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Gemma C. Atkinson @gemmaatkinson.bsky.social · 19/05/2025
Really excited to share our resource and analysis of AlphaFold-predicted monomers and homodimers across viruses and phages. Project driven by fab PhD student @rodai.bsky.social and with our great collaborators Joana Pereira @joanampereira.bsky.social and @ninjani.bsky.social
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Victor Klein-Sousa @vkleinsousa.bsky.social · 28/04/2025
I'm happy to see that our collaboration is out on npj viruses! I had a fun time modelling T-even #phages adhesin proteins. Verifying that we can use #AF2 bias to select true binders was even cooler. Congrats to Veronika Lutz and all www.nature.com/articles/s44...
nature.com
Gp38 adhesins of Straboviridae phages recognize specific extracellular loops of outer membrane protein receptors - npj Viruses
npj Viruses - Gp38 adhesins of Straboviridae phages recognize specific extracellular loops of outer membrane protein receptors
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Aritz Roa-Eguiara @aritz-roa.bsky.social · 22/04/2025
🚨Super happy to see this preprint out!! Main part of Leyre’s PhD journey on the eCIS from Photorhabdus luminescens. Full structure using #cryoEM Check it out! 🎊 www.biorxiv.org/content/10.1...
biorxiv.org
Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states.
Contractile injection systems (CISs) are phage-tail-like nanosyringes that mediate bacterial interactions by puncturing target cell membranes. Within these systems, Photorhabdus Virulence Cassettes (P...
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Gemma C. Atkinson @gemmaatkinson.bsky.social · 25/02/2025
Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...
academic.oup.com
LoVis4u: a locus visualization tool for comparative genomics and coverage profiles
Abstract. Comparative genomic analysis often involves visualization of alignments of genomic loci. While several software tools are available for this task
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 16/02/2025
🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.
TM equation of Zhang and Skolnick
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Alexander Harms @aharms485.bsky.social · 06/02/2025
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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Victor Klein-Sousa @vkleinsousa.bsky.social · 30/01/2025
That's pretty cool! I’ve always wondered why more phages don’t have RBPs on their capsids - great to see them interacting with cryoET. I’m curious to see what types of adaptors these fibers have and how abundant they are. Great work :)
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Franklin Nobrega @fnobrega.bsky.social · 24/01/2025
Happy to share our latest findings on Kiwa. Foundational work from Thomas, with Zhiying and Yi providing beautiful structures and molecular insights. Ever grateful for the collaborations with Eugene and Dinshaw. More to come 🙃 doi.org/10.1101/2023...
doi.org
Kiwa is a bacterial membrane-embedded defence supercomplex activated by phage-induced membrane changes
Bacteria and archaea deploy diverse, sophisticated defence systems to counter virus infection, yet many immunity mechanisms remain poorly understood. Here, we characterise the Kiwa defence system as a...
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