iiinova — where your digital self keeps evolving

Vincent Noël @vincent-noel.fr · 07/10/2026

⏰ One week left to submit your abstract to VI SysBioRio! 📅 Nov 3–6, at UFRJ, right next to Praia Vermelha, Rio de Janeiro 🏖️ 🔗 Register: www.even3.com.br/vi-sysbiorio... 📸 More info: www.instagram.com/sysbiorio/ 🧵

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Vincent Noël @vincent-noel.fr · 08/11/2024

Finally, we show a complete rewrite of @MRuscone cancer invasion model, removing most of the C++ code, and replacing it with the new mapping system. A larger scale, real-world example of how to use the latest #PhysiBoSS functionalities!

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Vincent Noël @vincent-noel.fr · 08/11/2024

Third example had to be an immune example, since this is the most important application for #PhysiBoSS! We describe DCs, attracted by the CCL21 gradient toward the lymph node. There, they activate naive T-cells which differentiate in TH1,TH17 and Tregs (model from Corral et al.).

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Vincent Noël @vincent-noel.fr · 08/11/2024

The second has been one of our goals with #PhysiBoSS for a long time: a signaling-controlled cell cycle model. Using the #Boolean model from Sizek et al., we link the cyclins to the transitions of the phases of the cell cycle. With that, we can reproduce the effect of mutants!

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Vincent Noël @vincent-noel.fr · 08/11/2024

The first example is inspired by the TNF example of the original #PhysiBoSS. It shows how to quickly map a substrate concentration to a Boolean input, and an output to #PhysiCell's apoptosis and necrosis. It simulates long vs pulsatile treatment, necrotic core, and clonality!

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Vincent Noël @vincent-noel.fr · 08/11/2024

In this tutorial, the user only needs to use #PhysiCell studio to build, parametrize, simulate and explore the simulation results! We implemented full PhysiBoSS compatibility in the studio, so that you can add your signaling model, and explore the #Boolean state of every cell in the results !

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Vincent Noël @vincent-noel.fr · 08/11/2024

Our #PhysiBoSS tutorial is now available at Briefings in Bioinformatics: academic.oup.com/bib/article/.... Learn how to build #multiscale models with #Boolean intracellular signaling, without any code, using #PhysiCell Studio! Showing three simple examples, and an update of Ruscone's invasion model👇

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Vincent Noël @vincent-noel.fr · 04/07/2024

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Vincent Noël @vincent-noel.fr · 04/07/2024

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Vincent Noël @vincent-noel.fr · 04/07/2024

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Vincent Noël @vincent-noel.fr · 04/07/2024

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Vincent Noël @vincent-noel.fr · 04/07/2024

Our #PhysiBoSS tutorial is finally available as a preprint: arxiv.org/abs/2406.18371! Learn how to build #multiscale models with #Boolean intracellular signaling, without any code, using #PhysiCell Studio. Showing 3 simple examples, and an update of @MRuscone invasion model 👇

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