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Vinay Prasad's Observations and Thoughts

@vinayprasadmdmph.skystack.xyz
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Dr Prasad currently works at the US FDA. The writings on this platform were posted before my FDA employment and do not necessarily re... This is an automated Substack Account of vinayprasadmdmph.substack.com Discover more/Create at: @skystack.xyz

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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 5h
Retatrutide - Astonishing weight loss; mild HR elevation
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Retatrutide - Astonishing weight loss; mild HR elevation
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 30/09/2026
Pancreas cancer: How 92% becomes 45% in 15% • Tango therapeutics
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Pancreas cancer: How 92% becomes 45% in 15%
Tango therapeutics
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 28/09/2026
Public health fails in ways it can’t even see
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Public health fails in ways it can’t even see
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 27/09/2026
Merit, Excellence, and Intelligence or DEI (diversity equity and inclusion) • Start ups vs Entrenched institutions
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Merit, Excellence, and Intelligence or DEI (diversity equity and inclusion)
Start ups vs Entrenched institutions
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 25/09/2026
Do patients have a right to AI recordings? • What about a video?
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Do patients have a right to AI recordings?
What about a video?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 24/09/2026
The primary, pre-specified outcome is negative, but what about this interesting secondary outcome?
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The primary, pre-specified outcome is negative, but what about this interesting secondary outcome?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 23/09/2026
Mulicancer early detection tests • What you need to know
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Mulicancer early detection tests
What you need to know
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 22/09/2026
Should NIH funding be 100 billion? What about 500 billion? • When you don’t acknowledge trade offs you can’t take a principled stance
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Should NIH funding be 100 billion? What about 500 billion?
When you don’t acknowledge trade offs you can’t take a principled stance
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 21/09/2026
How to think about confidence intervals and p values
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How to think about confidence intervals and p values
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 20/09/2026
Crossroads: the great American novel
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Crossroads: the great American novel
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 17/09/2026
Hiring specialists is is the problem with the USPSTF? Or is it preventive medicine itself? • Dishonest media coverage
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Hiring specialists is is the problem with the USPSTF? Or is it preventive medicine itself?
Dishonest media coverage
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 14/09/2026
There will always be an AI whistleblower who believes it threatens all human beings • Think about the distribution of opinions
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There will always be an AI whistleblower who believes it threatens all human beings
Think about the distribution of opinions
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 11/09/2026
Is there a ‘10%’ chance AI kills us all, or cures all diseases?
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Is there a ‘10%’ chance AI kills us all, or cures all diseases?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 10/09/2026
When failing institutions complain about losing support and funding • The United States Preventive Services Task Force.
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When failing institutions complain about losing support and funding
The United States Preventive Services Task Force.
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 09/09/2026
Cancer breakthroughs: Hope or hype
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Cancer breakthroughs: Hope or hype
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 08/09/2026
Looksmaxxing: does it work? is it dangerous?
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Looksmaxxing: does it work? is it dangerous?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 06/09/2026
Why don’t we have more cancer cures? • 10 reasons that go beyond the New York Times.
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Why don’t we have more cancer cures?
10 reasons that go beyond the New York Times.
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 05/09/2026
Cancer drug prices keep going up, now $477,000 per year of therapy • Lessons learned 2012-26
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Cancer drug prices keep going up, now $477,000 per year of therapy
Lessons learned 2012-26
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 03/09/2026
The CDC and Pennsylvania won’t agree if 2 people died of measles • Josh Shapiro has failed
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The CDC and Pennsylvania won’t agree if 2 people died of measles
Josh Shapiro has failed
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 01/09/2026
Target trials are a failed methodology • A recent target trial is contradicted by a randomized study in 2 days.
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Target trials are a failed methodology
A recent target trial is contradicted by a randomized study in 2 days.
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 01/09/2026
My interview for the Doctors Lounge
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My interview for the Doctors Lounge
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 28/08/2026
Josh Shapiro is in trouble • Free advice to the governor and other politicians regarding public health
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Josh Shapiro is in trouble
Free advice to the governor and other politicians regarding public health
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 27/08/2026
Does the shingles vaccine reduce cardiovascular events? • Nature medicine strikes out... again
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Does the shingles vaccine reduce cardiovascular events?
Nature medicine strikes out... again
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 26/08/2026
Two recent interviews • Wanted to make two recent interviews available to you all
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Two recent interviews
Wanted to make two recent interviews available to you all
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 26/08/2026
I have 3 problems with the letter opposing the punishment of Nathan Cofnas • Don't restore Nathan, fire the Rector
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I have 3 problems with the letter opposing the punishment of Nathan Cofnas
Don't restore Nathan, fire the Rector
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 24/08/2026
Should we ban pre-med and medical student research? • The sentiment is spot on, even if the solution is impractical.
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Should we ban pre-med and medical student research?
The sentiment is spot on, even if the solution is impractical.
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 23/08/2026
Have the sciences been hopelessly captured by “woke ideologues with contempt for truth, evidence and common sense”? • Steven Pinker is right about the question, but wrong about the answer.
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Have the sciences been hopelessly captured by “woke ideologues with contempt for truth, evidence and common sense”?
Steven Pinker is right about the question, but wrong about the answer.
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 23/08/2026
Jason Arday, Nathan Cofnas, Cambridge, Ghent and NEJM Voices
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Jason Arday, Nathan Cofnas, Cambridge, Ghent and NEJM Voices
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 21/08/2026
Jason Arday in the New England Journal/ Nicholas Cofras’ Suspension letter • I am astonished both of these are in writing; and why the former is in a medical journal
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Jason Arday in the New England Journal/ Nicholas Cofras’ Suspension letter
I am astonished both of these are in writing; and why the former is in a medical journal
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 20/08/2026
10 thoughts about Jason Arday, Cambridge, Nathan Cofnas, and the decline of Universities.
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10 thoughts about Jason Arday, Cambridge, Nathan Cofnas, and the decline of Universities.
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 19/08/2026
Should folks older than 75 take a statin? • A french trial says no-- is the trial useful?
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Should folks older than 75 take a statin?
A french trial says no-- is the trial useful?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 18/08/2026
JAMA essay argues that AI will be better than docs; Docs upset; What’s the reality? • And: does it make sense to publish peer review articles about what AI will do?
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JAMA essay argues that AI will be better than docs; Docs upset; What’s the reality?
And: does it make sense to publish peer review articles about what AI will do?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 15/08/2026
It would have worked, If only. 'If only' medicine • Why we lost the game
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It would have worked, If only. 'If only' medicine
Why we lost the game
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 15/08/2026
A cluster randomized trial of HEPA filters is strikingly negative • Another failure of public health 'experts'
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A cluster randomized trial of HEPA filters is strikingly negative
Another failure of public health 'experts'
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 12/08/2026
Medical ethics and IRB committees make two errors: they block useful research, they permit useless research • Can they be fixed?
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Medical ethics and IRB committees make two errors: they block useful research, they permit useless research
Can they be fixed?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 10/08/2026
Fake numbers: closing USAID cost 14 million lives, vaccines saved 2 million • The media loves false and misleading statistics when they fit the liberal narrative
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Fake numbers: closing USAID cost 14 million lives, vaccines saved 2 million
The media loves false and misleading statistics when they fit the liberal narrative
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 07/08/2026
Five red flags cancer patients should look out for
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Five red flags cancer patients should look out for
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 07/08/2026
Former Covid Czar says lab leak, and who is responsible for decisions politicians or scientist
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Former Covid Czar says lab leak, and who is responsible for decisions politicians or scientist
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 04/08/2026
Who is accountable: political leaders or the scientists who advise them?
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Who is accountable: political leaders or the scientists who advise them?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 03/08/2026
White House Covid Czar Says He thinks it was Lab Leak • The Overton window keeps shifting
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White House Covid Czar Says He thinks it was Lab Leak
The Overton window keeps shifting
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 02/08/2026
Anthony Fauci
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Anthony Fauci
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 30/07/2026
Why Fauci Struck a Nerve - and 5 more diary updates • The media should at least aspire to explain and understand why so many feel so strongly-- they have failed to do so.
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Why Fauci Struck a Nerve - and 5 more diary updates
The media should at least aspire to explain and understand why so many feel so strongly-- they have failed to do so.
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 27/07/2026
6 lessons from Anthony Fauci's diary
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6 lessons from Anthony Fauci's diary
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 23/07/2026
What sport is safe enough for your kids to play? • Is soccer worse than football for concussions?
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What sport is safe enough for your kids to play?
Is soccer worse than football for concussions?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 22/07/2026
The Shingles vaccine DOES NOT reduce dementia in England • How the media does a disservice to vaccine research
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The Shingles vaccine DOES NOT reduce dementia in England
How the media does a disservice to vaccine research
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 22/07/2026
The wealthy and charitable family
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The wealthy and charitable family
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 21/07/2026
Coffee and the Heart - The new guidelines is based on very low level evidence (with 1 exception) • How low is too low to be helpful
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Coffee and the Heart - The new guidelines is based on very low level evidence (with 1 exception)
How low is too low to be helpful
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 20/07/2026
Is health care a human right? • What about health care that doesn't work?
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Is health care a human right?
What about health care that doesn't work?
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 17/07/2026
Clarifying a few misconceptions about lung cancer screening
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Clarifying a few misconceptions about lung cancer screening
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Vinay Prasad's Observations and Thoughts @vinayprasadmdmph.skystack.xyz · 16/07/2026
The Future of Medicine • Even the optimists are bearish
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The Future of Medicine
Even the optimists are bearish
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