Zika virus (ZIKV) is an arthropod-borne Orthoflavivirus that caused a major outbreak in Central and South America in 2015-16. During that outbreak, ZIKV infection during pregnancy was associated with high rates of adverse outcomes, including miscarriage and a spectrum of neurological birth defects c …

Lack of access to antiretroviral therapy (ART) leads to the transmission of human immunodeficiency virus in ~120,000 children annually, emphasizing the need for new strategies to prevent lifelong infection. Here in an infant rhesus macaque model of peripartum oral infection, we show that broadly neu …

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that infects 60%-90% of the population worldwide. In immunocompetent individuals, primary infection is asymptomatic and results in lifelong lat...

IntroductionThe functional responses of antigen (Ag) specific T cells are complex, clonotype-specific, context-dependent, and incompletely captured by domina...

Neuropathology in ART-suppressed PWH arises from convergent processes involving CNS HIV reservoirs, myeloid-driven neuroinflammation, systemic immune activation and gut-derived injury, rather than res...

O'nyong-nyong virus (ONNV) is a mosquito-borne alphavirus first isolated in Uganda in 1959. Since its discovery, ONNV has caused several outbreaks in Africa, manifesting clinically as fever, rash, and...

MicroRNAs (miRNAs) are small, noncoding RNAs that have emerged as powerful players in the post-transcriptional regulation of gene expression. In the context of viral infections, cellular miRNAs play s...

A T cell-based vaccine that targets the parasite as it infects the liver opens new possibilities for malaria, other parasite vaccines.

Malaria continues to exact a high disease burden worldwide, and improved vaccines and therapeutics are desperately needed. Both licensed vaccines target only the circumsporozoite protein (CSP) express...

Stimulator of interferon genes (STING) is a pattern recognition receptor that activates type I interferon and proinflammatory responses following cytosolic DNA exposure. Its pharmacologic stimulation ...

Arthritogenic alphaviruses, including chikungunya virus (CHIKV), Mayaro virus and Ross River virus, cause long-lasting musculoskeletal pain and inflammation. However, the mechanisms driving chronic disease remain unclear. Here, we used single-cell RNA sequencing, spatial transcriptomics and flow cyt …

Human cytomegalovirus (HCMV) establishes latency in CD34⁺ hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation. We demonstrate that the Notch signaling pathway, a key regulator of stem cell maintenance and differentiation, functions as …

Early HIV infection involves the transmission of a small number of virions and the subsequent expansion and spread of the virus. The early phases of infection represent an important opportunity for viral control, although relatively little is understood about the determinants of the rate of spread o …

This dataset represents the largest study of structural variation in rhesus macaques to date and demonstrates use of both long and short-read datasets to generate SV genotype data. These data enable the consideration of structural variation impact in rhesus macaque-based research and will also aid t …