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vflorelo

@vflorelo.bsky.social

41 followers 50 following 7 posts

Terrestrial animal | Biochemistry Cambridge University | Research Informatics Training | EMBL EBI Training

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vflorelo @vflorelo.bsky.social · 28/11/2025

Big shoutout to @rosswaller.bsky.social @nicolas3474.bsky.social and the man of the hour @scottchisholm.bsky.social 7/7

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vflorelo @vflorelo.bsky.social · 28/11/2025

And with that, we can start pushing the snowball so that people can select new drug targets, vaccine candidates, or simply better understand how malaria works. 6/7

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vflorelo @vflorelo.bsky.social · 28/11/2025

It's funny how we can summarise years of hard work in some scatter-, bar- and box-plots, but those plots tell an amazing story, a story on how we pushed the genome annotation of Plasmodium with 1600 proteins now spatially resolved. 5/7

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vflorelo @vflorelo.bsky.social · 28/11/2025

And just like that we ended up doing tons of analysis about everything: from evolutionary profiles, to physico-chemical properties, to 3D structure analysis, to functional annotations and everything in between. The next part was to conduct exhaustive statistical testing. 4/7

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vflorelo @vflorelo.bsky.social · 28/11/2025

We needed to make sense of all the data we had, Scott told me: "can you help me with X, Y & Z", to which I said: "Of course man, no problemo". 3/7

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vflorelo @vflorelo.bsky.social · 28/11/2025

Credit where credit is due, @scottchisholm.bsky.social optimised the procedure to obtain P. falciparum schizonts and merozoites, resolve the spatial proteome and assign locations to previously unknown proteins, but what was next? 2/7

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vflorelo @vflorelo.bsky.social · 28/11/2025

When I joined Ross' lab, he told me to process some Perkinsus genomes, little did I know that I would end up teaming with Scott in one of the most significant (if not the most) project of my academic life. (1/7)

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