The Immunobuddies · Episode

This cohort study examines the association of an immune checkpoint inhibitor–based multimodal pretransplant strategy with posttransplant oncologic outcomes and acute rejection among patients with hepa...

The HER2 REAL (NCT04857619) retrospective study explored treatment practices and survival outcomes in patients with human epidermal growth factor receptor 2 (HER2)–positive unresectable breast cancer/...

The European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with renal cell carcinoma (RCC) were published in May 2024 and adap...

Previous results from the single-arm, phase II KEYNOTE-427 study showed antitumor activity with first-line pembrolizumab monotherapy in advanced clear cell renal cell carcinoma (ccRCC) and non–clear c...

Small-cell lung cancer (SCLC) accounts for approximately 15% of lung cancers [1]. Over two-thirds of patients with SCLC have extensive-stage SCLC (ES-SCLC), whereby patients have distant metastatic di...

This prospective, double-blind, placebo-controlled, randomized clinical trial evaluated the role of memantine in preventing cognitive decline following radiotherapy (RT) for brain metastases (BM).

The SMAD4 transcription factor mediates TGF-β signal transduction and is frequently inactivated in pancreatic cancer (PC). This study evaluated SMAD4 (protein) expression in the NRG Oncology/RTOG 9704...

Preclinical data suggest that fractionated stereotactic radiotherapy (FSRT) may sensitize immunologically-cold tumors to immune checkpoint inhibition by stimulating neoantigen release and that inhibit...

Nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) infection. Epigallocatechin gallate (EGCG), a major effective compound in green tea extract, inhibits EBV reactivation. We co...

For patients with unresectable stage III non–small cell lung cancer (NSCLC) ineligible for concurrent chemo-radiation, stereotactic body radiotherapy (SBRT) may provide a favorable efficacy–toxicity b...

Iberdomide, daratumumab, and dexamethasone significantly improved MRD-negative complete response compared with daratumumab, bortezomib, and dexamethasone. The most common grade 3 or grade 4 adverse ev...

Our findings highlight the importance of infection control to achieve cancer prevention. Scientifically proven, but often underused, approaches include HPV and HBV vaccination; testing and treatment o...

Hypofractionated postmastectomy radiotherapy provided durable locoregional control with no increase in severe late adverse events compared with conventional fractionation, supporting its use as a more...

Objectives To assess the effects of prostate cancer screening compared to no screening in men with no prior diagnosis of prostate cancer. Methods This systematic review represents an update of a pr...

Introduction Oesophageal squamous cell carcinoma (OSCC) accounts for more than 85% of the global burden of oesophageal cancer, resulting in 500 000 deaths annually. In the UK, over two-thirds of OSCC ...

Background Patients with advanced non-small cell lung cancer who progress on immune checkpoint inhibitors (ICIs) face limited options and poor survival. Aglatimagene besadenovec (CAN-2409), a replicat...

AbstractBackground. Cognitive problems are common after breast cancer, yet few randomized controlled trials have evaluated interventions to address them. T

Purpose This study sought to compare the effectiveness of cognitive behavioral stress management (CBSM) and acceptance and commitment therapy (ACT) on the quality of life and fatigue of caregivers of ...

Artificial intelligence–based mammographic detection and short-term breast cancer risk prediction models performed best in their intended applications, with lower performance when applied outside t...

Giredestrant and everolimus target the estrogen receptor (ER) pathway and the phosphatidylinositol 3-kinase (PI3K)–protein kinase B (AKT)–mammalian target of rapamycin (mTOR) pathway, respectively,...

PURPOSEPost-operative stereotactic radiation (SRT) is the standard-of-care for resected brain metastases. Implantation of cesium-131 collagen tiles (tile-based radiation therapy, TBRT) initiates focal...

Background Technically resectable locally advanced head and neck squamous cell carcinoma may require highly morbid surgery. We evaluated short-course neoadjuvant anlotinib plus paclitaxel–cisplatin ...

Background Advances in systemic therapy for advanced hepatocellular carcinoma (HCC) have fuelled a growing interest in evaluating these therapies in earlier stages of disease. However, trial design re...

Background Advances in systemic therapy for advanced hepatocellular carcinoma (HCC) have fuelled a growing interest in evaluating these therapies in earlier stages of disease. However, trial design re...

Background Symptoms after upper gastrointestinal (UGI) cancer surgery are common, frequently overlap, and can substantially affect quality of life. Despite increasing recognition of this problem, ther...

Most older patients are now re-treated after relapsing from a first-line chemo-immunotherapy with inotuzumab. With a salvage regimen including blinatumomab or not, 50% of patients can achieve a secon...

Despite significant therapeutic progress, the heterogeneity of lung cancer biology and the emergence of multiple therapeutic options continue to complicate treatment optimization and real-world patie...

British Journal of Cancer - Neoadjuvant chemotherapy as a bridge to surgery versus direct surgery following SEMS placement in obstructive left-sided colon cancer: a multicenter prospective cohort...

British Journal of Cancer - A prospective observational study of treatment sequencing with regorafenib and FTD/TPI in metastatic colorectal cancer: The OSERO study

Objective To compare the analgesic efficacy, adverse effect profile, incidence of acute pain crises and opioid-sparing effects of intravenous ketamine versus lignocaine infusions in patients with refr...

The Immunobuddies · Episode

In this observational cohort, 50% of patients diagnosed with clear cell renal cell carcinoma who were eligible and fit for adjuvant pembrolizumab declined treatment after counselling. Safety and oncol...

Patients with testicular cancer achieve outstanding cure rates even at advanced metastatic stages. As discussed here, treatment success for advanced disease is closely linked to the multidisciplinary ...

Homologous recombination repair (HRR) gene alterations in metastatic castration-resistant prostate cancer (mCRPC) confer vulnerability to DNA-damaging therapies. Although poly (ADP-ribose) polymerase ...

Details regarding incidence and epidemiology are provided in Supplementary Material Section 1 (available at https://doi.org/10.1016/j.esmoop.2026.108364).

Our findings suggest that adjuvant radiotherapy should be considered in patients with atypical meningioma after complete surgical resection of atypical meningioma when the prevention of recurrence is ...

Both stereotactic radiotherapy (SRT) and novel systemic therapies, including targeted therapy and immunotherapy, play an increasingly important role in cancer treatment. Their concurrent use may impro...

Small cell lung cancer (SCLC) is characterized by rapid proliferation and early dissemination, with approximately one-third of patients presenting with limited-stage disease (LS-SCLC) at diagnosis [1–...

As a standard practice in intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC), elective neck irradiation (ENI) is required to cover the nodal regions harboring microscopic ...