Reposted by Vanesa Nieto Estevez
Dual developmental effects of ARX poly-alanine mutations on human cortical excitatory and inhibitory neurons
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Dual developmental effects of ARX poly-alanine mutations on human cortical excitatory and inhibitory neurons
Nieto-Estevez et al. show that ARX poly-alanine expansion mutations disrupt cortical and interneuron development in human brain organoids, revealing early network hyperactivity and offering insights into developmental epilepsies.
