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Julian F. Hillyer

@vandybugs.bsky.social
104 followers 83 following 39 posts

Centennial Professor of Biological Sciences at Vanderbilt University, Mosquito biologist, Entomologist, Parasitologist, Educator

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Julian F. Hillyer @vandybugs.bsky.social · 07/09/2026
Congrats to students Shabbir Ahmed and Puspa Shah. Our article The extracellular matrix proteins Pericardin and Lonely heart modulate the directionality of heart contractions in infected mosquitoes was published in Arch Insect Biochem Physiol @vanderbilt.edu doi.org/10.1002/arch...
doi.org
The Extracellular Matrix Proteins Pericardin and Lonely Heart Modulate the Directionality of Heart Contractions in Infected Mosquitoes
Pericardin and Lonely heart, which are components of the cardiac extracellular matrix, influence the direction in which the heart of mosquitoes propels hemolymph (blood).
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Julian F. Hillyer @vandybugs.bsky.social · 25/08/2026
Wonderful and inspiring to see the incoming graduate student class @vanderbilt.edu . First Convocation, and then hundreds visited Alumni Hall as they embark on their journey.
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Julian F. Hillyer @vandybugs.bsky.social · 19/05/2026
It's been a bit, but here's our latest article: "In mosquitoes, warmer temperature reverses the aging-dependent decrease in nitric oxide synthase activity, modifying the expression of oxidative stress and immune genes", published in Dev Comp Immunol. doi.org/10.1016/j.dc...
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Julian F. Hillyer @vandybugs.bsky.social · 18/05/2026
I always find it really neat to see anatomy papers across insect taxa. When comparing to other papers, one can see so much conservation across millions of years of evolution. Thought about ti when I saw this paper on silkworms. doi.org/10.1007/s004...
doi.org
A comparative study of internal organs of silkworm species (Bombyx mori, Samia ricini, Antheraea mylitta, Antheraea assamensis) using stereo-zoom microscopy - Zoomorphology
Sericulture is the practice of rearing silkworms on specific host plants for the production of natural silk. It has been carried out since ancient times. Among the various silkworms, the fully domesticated mulberry (Bombyx mori), the semi-domesticated Eri (Samia ricini) and the wild species or vanya silkworms- Muga (Antheraea assamensis) and Tasar (Antheraea mylitta) represent the major sources of commercial silk in India. Each species has distinct physiological and anatomical features that determine its feeding behaviour, silk production and adaptability to environmental conditions. Although their ecology, host plants, silk characteristics and rearing practices differ among these species, the internal anatomy of these silkworms follows a conserved lepidopteran pattern. In the present study, comparative analysis of internal organs and other external structures of all four different silkworm species were examined using a stereo zoom microscope. The major internal organ includes a digestive tract, tracheal system, circulatory system, nervous system, excretory system, silk gland and reproduction system. Observations revealed species-specific differences in tracheal coloration, silk gland development, fat-body texture and reproductive morphology, influenced by their ecological adaptation and host-plant specialization. External features such as true legs, pseudo-legs, spiracles, eyes and antennal structures of adult moths are also documented to provide integrated anatomical profiles. Such comparative analyses have helped to elucidate functional adaptations concerning feeding habits, cocoon formation, spinning behaviour and environmental tolerance.
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Julian F. Hillyer @vandybugs.bsky.social · 20/01/2026
New article from the lab published in Immunity & Ageing: Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair. doi.org/10.1186/s129...
doi.org
Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair - Immunity & Ageing
Immunity & Ageing - Global environmental temperatures are rising, which is increasing the body temperature of mosquitoes. This increase in body temperature is accelerating senescence, thereby...
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Julian F. Hillyer @vandybugs.bsky.social · 31/10/2025
Today was the Undergraduate Research Symposium ⁦ @vanderbilt.edu . Great time for the lab to get together, and great presentations by Norbu Shastri and Puspa Shah! ⁩
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Julian F. Hillyer @vandybugs.bsky.social · 21/10/2025
Consider contributing an article to the special issue of MDPI Insects titled "Insect Vector Physiology and Competence: Interactions and Adaptations". Questions? DM me.
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Julian F. Hillyer @vandybugs.bsky.social · 30/09/2025
New paper from the lab! When a mosquito ingests blood, the phagocytic activity of hemocytes increases with warmer environmental temperature and aging @vanderbilt.edu @vuartsci.bsky.social @evolutionvu.bsky.social doi.org/10.1016/j.ji...
doi.org
Redirecting
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Julian F. Hillyer @vandybugs.bsky.social · 19/09/2025
New paper: Phagocytic hemocytes, independent of pericardial cells, modulate cellular immune responses on the dorsal vessel of mosquitoes, including the infection-induced reduction of the heart rate @vanderbilt.edu @evolutionvu.bsky.social @vuartsci.bsky.social doi.org/10.1007/s004...
doi.org
Phagocytic hemocytes, independent of pericardial cells, modulate cellular immune responses on the dorsal vessel of mosquitoes, including the infection-induced reduction of the heart rate - Cell and Ti...
Infection induces the aggregation of hemocytes on the dorsal vessel of mosquitoes. These hemocytes, called periostial hemocytes, phagocytose pathogens and produce immune factors on the abdominal porti...
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Julian F. Hillyer @vandybugs.bsky.social · 03/09/2025
Excited to announce our latest article, with possibly the longest title ever. We demonstrate how warmer temperature accelerates the aging-dependent changes to the reproductive tissues of mosquitoes. @vanderbilt.edu @vuartsci.bsky.social @evolutionvu.bsky.social doi.org/10.3390/inse...
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Julian F. Hillyer @vandybugs.bsky.social · 26/08/2025
Biological Sciences seminar series @vanderbilt.edu kicked off for the year with Dr. Ryan Smith @vectorimmunity.bsky.social presenting on his new discoveries on mosquito hemocytes. Great talk!
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Julian F. Hillyer @vandybugs.bsky.social · 13/08/2025
Happy to announce that I added a new role @vanderbilt.edu : Associate Dean for Academic Affairs of the Graduate School. I'm excited to go on this journey with Dean André Christie-Mizell, Associate Dean Andrea Page-McCaw, and the Graduate School team.
news.vanderbilt.edu
Vanderbilt Graduate School announces leadership transitions
After concluding her term as associate dean for academic affairs for the Graduate School, Terrah Akard will return to her role as professor of nursing in the School of Nursing. Julián Hillyer, Centenn...
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Julian F. Hillyer @vandybugs.bsky.social · 12/08/2025
With the summer term having just ended, I'm super proud of Puspa Shah for her summer research as part of the Vanderbilt University Summer Research Program. @vanderbilt.edu @vuartsci.bsky.social
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Julian F. Hillyer @vandybugs.bsky.social · 02/07/2025
Proud to announce our latest research! Warmer temperature accelerates reproductive senescence in mosquitoes. @vanderbilt.edu @evolutionvu.bsky.social @vuartsci.bsky.social doi.org/10.3389/fphy...
doi.org
Frontiers | Warmer temperature accelerates reproductive senescence in mosquitoes
To reproduce, most female mosquitoes must ingest blood to obtain nutrients for viable eggs. Global warming is increasing mosquito body temperature and hamper...
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Julian F. Hillyer @vandybugs.bsky.social · 19/06/2025
Hillyer lab lunch! @vuartsci.bsky.social @vanderbilt.edu @evolutionvu.bsky.social
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Julian F. Hillyer @vandybugs.bsky.social · 02/06/2025
Cellular immune senescence in mosquitoes accelerates when the temperature is warmer. Great research by then grad student Dr. Jordyn Barr and then undergrad Saksham Saksena published in Developmental and Comparative Immunology. @vanderbilt.edu @evolutionvu.bsky.social doi.org/10.1016/j.dc...
doi.org
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Julian F. Hillyer @vandybugs.bsky.social · 19/05/2025
Congratulations to the 2025 @vanderbilt.edu Department of Biological Sciences Graduate Student Award winners! @vuartsci.bsky.social
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Julian F. Hillyer @vandybugs.bsky.social · 12/05/2025
Histamine and serotonin alter retinal sensitivity in mosquitoes. Great research by @shirleyluckhart.bsky.social and colleagues. doi.org/10.1371/jour...
doi.org
Regulation of diel locomotor activity and retinal responses of Anopheles stephensi by ingested histamine and serotonin is temperature- and infection-dependent
This study explores histaminergic and serotonergic signaling-dependent diel locomotor activity and visual sensitivity in the highly invasive malaria vector Anopheles stephensi. Histamine and 5-HT bloo...
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Julian F. Hillyer @vandybugs.bsky.social · 12/05/2025
Super congrats to Dr. Jordyn Barr for receiving her PhD diploma @vanderbilt.edu #VU2025 . She is an amazing scientist!
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Julian F. Hillyer @vandybugs.bsky.social · 29/04/2025
Hillyer lab lunch!
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Julian F. Hillyer @vandybugs.bsky.social · 29/04/2025
Identification of long noncoding RNAs (lncRNAs) and co-transcriptional analysis of mRNAs and lncRNAs in transcriptomes of Anopheles gambiae doi.org/10.3389/frna...
doi.org
Frontiers | Identification of long noncoding RNAs (lncRNAs) and co-transcriptional analysis of mRNAs and lncRNAs in transcriptomes of Anopheles gambiae
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Julian F. Hillyer @vandybugs.bsky.social · 11/03/2025
Congrats to Dr. Jordyn Barr (center) for successfully defending her PhD‬⁩ @vanderbilt.edu ‬⁩ @vuartsci.bsky.social !
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Julian F. Hillyer @vandybugs.bsky.social · 08/02/2025
I’ll share a positive. We had a great lab lunch this week. I am super proud of my team for their scholarship, their dedication, their collaborative spirit, and coming together to form a family. I’m very fortunate to lead this team! @vanderbilt.edu @vuartsci.bsky.social @evolutionvu.bsky.social
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Jason Rasgon @vectorgen.bsky.social · 09/01/2025
New paper in collabroation with @joshuabenoit.bsky.social lab! www.sciencedirect.com/science/arti...
sciencedirect.com
Multiple blood feeding bouts in mosquitoes allow for prolonged survival and are predicted to increase viral transmission during dry periods
Dry conditions increase blood feeding in mosquitoes, but it is unknown if dehydration-induced bloodmeals are increased beyond what is necessary for re…
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Shirley Luckhart @shirleyluckhart.bsky.social · 10/01/2025
New work with my longtime collaborator and friend Mike Riehle and his team. Fascinating to begin to unravel the biology of vitamin B5/pantothenate in Anopheles stephensi. More to come on this.
mdpi.com
Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito Anopheles stephensi and Its Capacity to Mobilize Pantothenate and Biotin
Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. We previously demonstrated that Pan is not only ess...
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Reposted by Julian F. Hillyer
Don Yee @mosquitolab.bsky.social · 10/01/2025
Sharing this again. Please share widely with any interested students. Puerto Rico is an amazing place to work. Deadline is in about a month but need to conduct interviews with prospective candidates well before then.
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Becky Smith @rlsdvm.bsky.social · 23/12/2024
246/250 is Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes I'm very grateful to the people who can do this necessary, careful lab work that we'll need to model climate change impacts on vectors!
doi.org
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes - Immunity & Ageing
Background Most insects are poikilotherms and ectotherms, so their body temperature is predicated by environmental temperature. With climate change, insect body temperature is rising, which affects ho...
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Julian F. Hillyer @vandybugs.bsky.social · 24/12/2024
One more highlight of 2024. Grad students Cole Meier (graduated) and Shabbir Ahmed and their paper in Developmental & Comparative Immunology: Extracellular matrix proteins Pericardin and Lonely heart mediate periostial hemocyte aggregation in the mosquito Anopheles gambiae doi.org/10.1016/j.dc...
doi.org
Redirecting
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Julian F. Hillyer @vandybugs.bsky.social · 23/12/2024
As we end 2024, and continuing to highlight grad student Lindsay Martin, here is her paper in @jexpbiol.bsky.social : Senescence of humoral antimicrobial immunity occurs in infected mosquitoes when the temperature is higher doi.org/10.1242/jeb....
doi.org
Senescence of humoral antimicrobial immunity occurs in infected mosquitoes when the temperature is higher
Summary: Higher temperature causes an aging-dependent decline in antimicrobial activity following infection, accelerating the onset of immune senescence.
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Julian F. Hillyer @vandybugs.bsky.social · 23/12/2024
Next up to highlight as we end 2024 is grad student Lindsay Martin and her paper in PLOS Pathogens: Higher temperature accelerates the aging-dependent weakening of the melanization immune response in mosquitoes doi.org/10.1371/jour...
doi.org
Higher temperature accelerates the aging-dependent weakening of the melanization immune response in mosquitoes
Author summary Climate change is increasing global temperatures, and this is altering the ecosystems that organisms inhabit. Insects are particularly susceptible to temperature changes because their b...
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Julian F. Hillyer @vandybugs.bsky.social · 23/12/2024
With 2024 coming to an end, I'll do a select lab recap. First, grad student Jordyn Barr and her work published in Immunity & Ageing: Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes doi.org/10.1186/s129...
doi.org
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes - Immunity & Ageing
Background Most insects are poikilotherms and ectotherms, so their body temperature is predicated by environmental temperature. With climate change, insect body temperature is rising, which affects ho...
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Shirley Luckhart @shirleyluckhart.bsky.social · 19/12/2024
Our brand new review on type 2 immunity in malaria with terrific colleagues Renee Tsolis and Adrian Piliponsky highlighting the roles of mast cells and basophils in orchestrating the host response to infection and parasite transmission to Anopheles mosquitoes.
cell.com
The type 2 immune response in gut homeostasis and parasite transmission in malaria
Malaria predisposes to concomitant bacteremia, resulting in increased mortality risk. Previous studies indicated that malaria causes structural changes in the intestine, induces tolerogenic immune responses, inhibits neutrophil recruitment, suppresses innate synthesis of IFN-γ, dysregulates mast cells (MCs) and basophils, and induces Th2-type immune responses. These can reduce parasite control while increasing enteropathogenic dissemination. Moreover, there is growing evidence that Th2 immunity, while protecting the host from overwhelming inflammation, may also contribute to increased parasite transmission. This review explores the roles of the regulatory immune response in bacterial coinfections and parasite transmission in malaria.
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Julian F. Hillyer @vandybugs.bsky.social · 19/12/2024
Hillyer Lab lunch (without the undergrads, who are on break)
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Rebecca C Christofferson @rchristo.bsky.social · 17/12/2024
New paper on #microclimate effects on #arbovirus transmission from my lab just out! As always, proud of my team! #zika #chikungunya www.mdpi.com/2076-0817/13...
mdpi.com
Investigating the Effects of Microclimate on Arboviral Kinetics in Aedes aegypti
Aedes aegypti are indoor-dwelling vectors of many arboviruses, including Zika (ZIKV) and chikungunya (CHIKV). The dynamics of these viruses within the mosquito are known to be temperature-dependent, a...
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Julian F. Hillyer @vandybugs.bsky.social · 17/12/2024
New paper from the lab! Activation of the immune deficiency pathway (IMD) reduces the mosquito heart rate via a nitric oxide-based mechanism published in Journal of Insect Physiology doi.org/10.1016/j.ji...
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Julian F. Hillyer @vandybugs.bsky.social · 16/12/2024
Joining Bluesky! I am a Professor at Vanderbilt University. My lab studies insect physiology, concentrating on the immune and circulatory systems of mosquitoes. As a means of introduction, over the next few days I will post some of our recent papers. I'm excited to join Bluesky!
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