Reposted by USC CGE
Family-based GWAS have become the gold standard for assessing causal genetic effects. They’re often said to offer an unbiased estimate of the average causal effect (ATE) of an allele or PGS. Here, we (Carl Veller & @mollyprz.bsky.social ) evaluate such statements.
www.biorxiv.org/content/10.1... 1/n
biorxiv.org
Causal interpretations of family GWAS in the presence of heterogeneous effects
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