New preprint from the @MullerForce @bsse.ethz.ch !!! Together with @NicoStrohmeyer we show how integrin-type dictates how the cell surface senses and integrates biomechanical information as it begins to decode its environment.
doi.org/10.64898/202...
Stay tuned!
doi.org
α5β1 and αvβ3 integrins employ two distinct adhesion strengthening modes to respond to fibronectin stiffness within seconds of initiating adhesion
The complex interplay between extracellular matrix stiffness and actomyosin contractility regulates long-term integrin-based adhesion and signaling in mammalian cells. However, how cells sense and res...
