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Upeksha Dissanayake

@upeksha.bsky.social

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Reposted by Upeksha Dissanayake

G. Andrés Cisneros @cisnerosres.bsky.social · 16/04/2025

Finally online! Latest paper from our group, by @upeksha.bsky.social in collaboration with Carlos Trasviña and Sheila David: #NIHfunded rdcu.be/ehTLp

Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair

Nature Communications - MUTYH removes A mis-incorporated opposite oxidized guanine to thwart mutations. Here, the authors present crystal structures and assess functional impacts and molecular...

Reposted by Upeksha Dissanayake

G. Andrés Cisneros @cisnerosres.bsky.social · 12/03/2025

Latest paper from the group is out, great contribution by @upeksha.bsky.social for a collaboration with CINVESTAV and LANGEBIO colleagues in México febs.onlinelibrary.wiley.com/doi/10.1111/... #NIHFunded

febs.onlinelibrary.wiley.com

Reactive oxygen species induce mutagenic DNA lesions, such as 8-oxo-2′-deoxyguanosine (8-oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Speci....