High-throughput experimental validation of genetic variants linked to eight psychiatric disorders reveals the regulatory mechanisms underlying variants with pleiotropic and disorder-specific effects.

Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system.

Harvard Neuroscientist David D. Ginty, PhD, will receive the Perl-UNC Neuroscience Prize for his pivotal discoveries on the sensation of touch and how our body communicates with the brain.

This position is being recruited as a primary faculty rank with a secondary non-faculty director role. Applicants must be able to hold a primary faculty rank in a School of Medicine Department. The Di...