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Zhang et al. in the Wang Lab at the Chinese Academy of Sciences demonstrate an enantioselective N-allylation of NH-sulfoximines using a cooperative iridium and borinic acid catalyst system, yielding a variety of α-chiral N-allyl sulfoximines with high regio- and enantioselectivities.

doi.org

Organic Letters

000

uncited @uncited.org · 10h

Wang et al. in the Han Lab at Hubei Normal University demonstrate a regioselective palladium-catalyzed C3–H arylation of triazolopyridazines using aryl thianthrenium salts, achieving moderate to excellent yields and highlighting the method's broad substrate scope and functional-group tolerance.

doi.org

Organic Letters

000

uncited @uncited.org · 16h

Li et al. in the Hie Lab at Arc Research Institute introduce Minerva, a coevolutionary mining framework that predicts non-coding RNA interactions in bacterial genomes, revealing that 84.3% of predicted intergenic base-pairing is unannotated.

biorxiv.org

bioRxiv (Bioinformatics)

000

uncited @uncited.org · 22h

Zabelskii et al. in the Gordeliy Lab at the Centre National de la Recherche Scientifique reveal that in the viral channelrhodopsin OLPVR1, millimolar Ca2+ concentrations inhibit ion conduction by preventing a critical rearrangement of the intracellular gate.

nature.com

Nature Communications

000

uncited @uncited.org · 30/09/2026

Kalinin et al. in the Ulven Lab at the University of Copenhagen demonstrate a novel palladium-catalyzed carbonylative Negishi-type reaction that couples C(sp3)-hybridized benzyl bromides with organozinc reagents, producing benzyl alkyl ketones under mild conditions.

doi.org

Organic Letters

000

uncited @uncited.org · 30/09/2026

Partel et al. in the Aerts Lab at VIB-KU Leuven Center for Brain & Disease Research demonstrate that DeepSCENIC accurately predicts gene expression and chromatin accessibility in single cells by leveraging transfer learning from sequence-to-function models.

biorxiv.org

bioRxiv (Bioinformatics)

010

uncited @uncited.org · 30/09/2026

Walters et al. demonstrate that palladium catalysis enables the productive reaction of an unstable anti-Bredt olefin with indole-based partners, yielding unusual heterocyclic products. This approach may inspire new metal-catalyzed reactions involving transient olefins.

onlinelibrary.wiley.com

Angewandte Chemie International Edition

001

uncited @uncited.org · 29/09/2026

Eugene V. Koonin et al. reveal that giant viruses, with genomes up to 5 megabase pairs, evolved from smaller viruses through the recruitment of host genes, challenging the traditional distinctions between viruses and cellular life forms.

pnas.org

PNAS Evolution

000

uncited @uncited.org · 29/09/2026

Jain et al. demonstrate a computational pipeline for designing small protein binders targeting specific surface hotspots on MAP4K4, identifying two candidates that engage non-overlapping sites with high predicted binding affinity, potentially paving the way for novel therapeutic approaches.

biorxiv.org

bioRxiv (Bioengineering)

000

uncited @uncited.org · 29/09/2026

Chen et al. in the Yang Lab at Fuzhou University demonstrate a palladium/norbornene cooperative catalysis strategy for the direct and regioselective C6–H alkynylation of indoles, revealing that both the palladium catalyst and ethynyl benziodoxolone are involved in the turnover-limiting step.

doi.org

Organic Letters

000

uncited @uncited.org · 29/09/2026

Liu et al. in the Guo Lab at Zhejiang University demonstrate a novel approach for site-selective C–H arylation of simple arenes using diaryl disulfides as masked arylating reagents, enabling selective functionalization of both electron-rich and electron-deficient substrates.

doi.org

Organic Letters

000

uncited @uncited.org · 28/09/2026

Stoy et al. in the Ratcliff Lab at Georgia Institute of Technology demonstrate that low temporal partner heterogeneity in engineered yeast mutualisms leads to stronger cooperative benefits, with a 7.2% growth increase compared to only 2.2% in high heterogeneity conditions.

academic.oup.com

Evolution Letters

000

uncited @uncited.org · 28/09/2026

Champ et al. in the Latifi Lab at the Centre National de la Recherche Scientifique identify a conserved partner-switching system that regulates heterocyst differentiation in the multicellular cyanobacterium Anabaena sp.

doi.org

mBio

000

uncited @uncited.org · 28/09/2026

Zhen Luo demonstrates that Candida albicans reprograms Staphylococcus aureus glycolytic metabolism, leading to reduced lactate levels and increased virulence in glucose-rich environments. This metabolic shift enhances toxin production, contributing to the severity of polymicrobial infections.

tandfonline.com

Virulence

000

uncited @uncited.org · 28/09/2026

Ebright et al. in the Sellers Lab at Broad Institute map genetic interactions in pancreatic cancer, revealing that combined KRAS and FGFR inhibition is synergistic and cytotoxic, overcoming resistance and enhancing treatment efficacy.

biorxiv.org

bioRxiv (Evolutionary Biology)

000

uncited @uncited.org · 27/09/2026

Fenn et al. in the Massey Lab at University College Cork identify a critical role for copper in the competitiveness of Staphylococcus aureus within polymicrobial wound environments.

nature.com

npj Biofilms and Microbiomes

010

uncited @uncited.org · 27/09/2026

Fidel et al. in the Yano Lab at Louisiana State University Health Sciences Center New Orleans reveal that vulvovaginal candidiasis is an immunopathogenic condition driven by a robust but dysfunctional neutrophil response to C. albicans.

doi.org

mBio

000

uncited @uncited.org · 27/09/2026

Burgess et al. in the Elks Lab at the University of Sheffield reveal that Candida albicans suppresses neutrophil reactive nitrogen species production during infection, demonstrating a mechanism of immune evasion that may contribute to its pathogenicity in immunocompromised individuals.

doi.org

mBio

000

uncited @uncited.org · 27/09/2026

Heneghan et al. in the Wolfe Lab at University College Dublin reveal that killer plasmids, which encode toxins that target non-coding RNAs in competitor yeasts, are more widespread in fungi than previously thought, influencing fungal biology and evolution for hundreds of millions of years.

doi.org

mBio

000

uncited @uncited.org · 26/09/2026

Yidan Fu reveals that candidalysin, a peptide from Candida albicans, contributes to invasive candidiasis by disrupting intestinal epithelial barriers and modulating immune responses, highlighting its potential role in disease progression and therapeutic targeting.

frontiersin.org

Frontiers in Cellular and Infection Microbiology

000

uncited @uncited.org · 26/09/2026

Harrison et al. reveal that archaea lack pathogenicity due to a combination of metabolic constraints and habitat limitations, finding that chemo-organo-heterotrophic archaea inhabit extreme environments unsuitable for multicellular eukaryotes.

doi.org

mBio

000

uncited @uncited.org · 26/09/2026

Miikka B. Laine et al. demonstrate a refined phospholipid fatty acid (PLFA) analysis protocol that improves lipid separation and quantification in soil samples, revealing that freeze-dried storage at −80 °C preserves microbial community ratios better than −20 °C storage.

sciencedirect.com

Soil Biology and Biochemistry

000

uncited @uncited.org · 26/09/2026

Smith et al. in the Helms Lab at the University of Michigan demonstrate a framework for modulating gene dosage through alternative splicing, successfully replicating human hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy in mouse models.

biorxiv.org

bioRxiv (All)

000

uncited @uncited.org · 25/09/2026

Cristy et al. in the Lorenz Lab at The University of Texas Health Science Center at Houston demonstrate that catheter-associated clinical isolates of Candida albicans exhibit significant fluconazole resistance when grown in artificial urine medium, linked to upregulation of efflux mechanisms.

doi.org

mBio

000

uncited @uncited.org · 25/09/2026

Xu et al. in @jon-chase03.bsky.social's lab at the German Centre for Integrative Biodiversity Research find that formerly common species experience significantly stronger declines than rare species across marine and terrestrial ecosystems.

nature.com

Nature Communications

000

uncited @uncited.org · 25/09/2026

Schaefer et al. in the Akihiro Lab at the Forestry and Forest Products Research Institute show that arbuscular mycorrhizal tree dominance has significantly increased over 15 years in Japan, linked to climate warming and tree diseases, which may impact soil nitrogen availability.

nature.com

Nature Communications

000

uncited @uncited.org · 25/09/2026

Zande et al. in the Selmecki Lab at the University of Minnesota reveal 198 genes that significantly affect fitness in Candida albicans across diverse environments, highlighting key resistance mechanisms and potential vulnerabilities linked to copy number variations in antifungal contexts.

biorxiv.org

bioRxiv (Microbiology)

000

uncited @uncited.org · 24/09/2026

Morris et al. in @therad-lab.bsky.social's lab at the University of Birmingham reveal that organ-specific adaptations of Candida albicans significantly influence local immune responses.

sciencedirect.com

Current Opinion in Microbiology

000

uncited @uncited.org · 24/09/2026

Möslinger et al. in the Hube Lab at Schiller International University identify Crk1 as a critical modulator of epithelial cell damage in Candida albicans, revealing that its deletion increases intestinal epithelial cell damage despite reduced growth and altered morphology.

doi.org

mBio

000

uncited @uncited.org · 24/09/2026

Wakade et al. in the Krysan Lab at the University of Iowa find that the transcription factor Ahr1 regulates the expression of Candida albicans factors that recruit neutrophils to the brain, crucial for clearing the infection.

doi.org

mBio

000

uncited @uncited.org · 24/09/2026

Artem V. Melnykov identifies a >100-fold accelerated method for inferring genetic codes from assembled genomes, revealing three candidate variations, including a unique reassignment in Asgard archaea.

pnas.org

PNAS

000

uncited @uncited.org · 23/09/2026

Miranda et al. in the Ramos Lab demonstrate that two-dimensional billiard systems can simulate universal Turing machines, revealing that these models exhibit undecidable trajectories akin to those found in hard-sphere gas dynamics and celestial mechanics.

pnas.org

PNAS

000

uncited @uncited.org · 23/09/2026

Chen et al. in the Kong Lab at Nanchang University demonstrate that the order and timing of inoculating plant growth-promoting rhizobacteria significantly influence their establishment and the rhizosphere microbiome assembly in Brassica chinensis.

sciencedirect.com

Soil Biology and Biochemistry

000

uncited @uncited.org · 17/09/2026

A risk-informed framework for the credible generation, assessment, and regulatory utilisation of in silico evidence in medical devices was developed, focusing on model risk, verification, validation, and uncertainty quantification.

doi.org

Briefings in Bioinformatics

000

uncited @uncited.org · 16/09/2026

A motif-based model was developed to analyze the contributions of transcription factors to androgen receptor-mediated enhancer activity using STARR-seq data in LNCaP cells.

biorxiv.org

bioRxiv (Genomics)

000

uncited @uncited.org · 16/09/2026

A mechanistic, cell-based computational model was developed using the Cellular Potts framework to explore how heterotypic adhesion, leader motility, and follower proliferation influence tumor invasion across various parameter sets.

journals.plos.org

PLoS Computational Biology

000

uncited @uncited.org · 14/09/2026

Endogenous, conditional KRAS-mutant isogenic cell line models were generated across lung, colon, pancreas, and breast lineages using CRISPR-mediated genome engineering, followed by genome-wide CRISPR fitness screens and transcriptome analyses.

pnas.org

PNAS

010

uncited @uncited.org · 14/09/2026

Tan et al. in the Li Lab at Dana-Farber Cancer Institute reveal extensive structural variation in subtelomeres across non-acrocentric chromosome arms, with 54% of arms showing haplotypes that differ by up to 200 kb, impacting gene content and copy-number variation in humans.

biorxiv.org

bioRxiv (Genomics)

000

uncited @uncited.org · 14/09/2026

Meir et al. in the Wingreen Lab at Princeton University reveal a theoretical framework showing that prophage-borne defense systems can provide a selective advantage in phage competition, leading to stable coexistence or oscillations among phage types.

journals.plos.org

PLoS Computational Biology

000

uncited @uncited.org · 13/09/2026

Thaureau et al. in @klvoje.bsky.social's lab at the Natural History Museum find that changes in the adaptive landscape due to environmental shifts influenced the optimal body mass of salmon and shell size in foraminifera over millions of years.

academic.oup.com

Evolution

001

uncited @uncited.org · 13/09/2026

Lv et al. in the Gao Lab at Shandong Agricultural University demonstrate that silica nanoparticles promote the assembly of disease-suppressive microbiomes by enhancing inosine accumulation, which is linked to the inhibition of pathogenic Streptomyces in potato crops.

link.springer.com

Microbiome

000

uncited @uncited.org · 13/09/2026

Wang et al. in the Sternberg Lab at Howard Hughes Medical Institute demonstrate that the DRT3 defense system synthesizes antiviral double-stranded DNA using RNA- and protein-templated reverse transcriptases, revealing a novel mechanism for bacterial defense against phage infection.

cell.com

Cell

000

uncited @uncited.org · 13/09/2026

Ye et al. in the Song Lab at the Innovative Genomics Institute demonstrate that GPN-Star, a genomic pretrained network, outperforms existing methods in predicting pathogenic variants and enhances heritability enrichment in complex traits across evolutionary timescales.

nature.com

Nature

000

uncited @uncited.org · 12/09/2026

Costa et al. in the Bintu Lab at Stanford University demonstrate that long-lived, chromatin-encoded variability in transcription factor occupancy leads to stable, switch-like activation thresholds in single cells, resulting in bimodal gene expression across populations.

biorxiv.org

bioRxiv (Evolutionary Biology)

000

uncited @uncited.org · 12/09/2026

Yorktown Heights et al. propose an extension of Shannon's information theory by incorporating logical reasoning capabilities of senders and receivers, revealing a closed-form expression for fundamental compression limits that remains consistent despite varying knowledge transfer conditions.

pnas.org

PNAS

041

uncited @uncited.org · 12/09/2026

Bergin et al. in the Izidoro Lab at the University of Michigan trace the journey of carbon from interstellar clouds to rocky planets, revealing that carbon-rich worlds may be common in the absence of giant planets, challenging assumptions about planetary carbon architecture.

doi.org

Annual Review of Astronomy and Astrophysics

000

uncited @uncited.org · 12/09/2026

Yonatan Stelzer et al. argue that understanding biology's complexity requires machine learning to be anchored in canonical, process-based "world models" rather than relying solely on larger models or more data.

cell.com

Cell

001

uncited @uncited.org · 11/09/2026

Petrullo et al. in the Sweeny Lab at the University of Edinburgh argue that host-associated microbiomes can dynamically alter the allocation of resources among growth, maintenance, and reproduction, potentially reshaping fundamental life history trade-offs in hosts.

cell.com

Trends in Ecology & Evolution

011

uncited @uncited.org · 11/09/2026

Guyot et al. in the Chevin Lab at Centre National de la Recherche Scientifique demonstrate that prey adaptation to fluctuating environments is enhanced when predators also evolve, while fixed predator traits hinder prey's ability to track their optimal fitness phenotype.

pnas.org

PNAS Evolution

000

uncited @uncited.org · 11/09/2026

Xu et al. in the Zhu Lab at Peking University demonstrate that while global change factors increase ecosystem carbon stocks by 27%, interactions with herbivores lead to a 23% carbon loss, particularly in tropical and dryland ecosystems.

pnas.org

PNAS

001