Reposted by Tzuwen Hong
Happy to share our latest paper.
Our findings uncover a unique chromatin architecture and spatial chromosome arrangement in gonadal germ cells and document that alongside global DNA demethylation, the germline epigenetic reprogramming involves reorganisation of the 3D genome.
nature.com
Global reorganization of genome architecture at the transition to gametogenesis - Nature Structural & Molecular Biology
Huang, Rigau and colleagues observe major changes in how DNA is organized in early germ cells before they start developing into sperm or eggs. These results show that germline removes structural ‘memo...
