Reposted by Tzippora Chwat-Edelstein
A study by @zhaolabski.bsky.social at @mskeducation.bsky.social and colleagues reveal how DNA and ATP binding by the multiple subunits of the SUMO ligase complex Smc5/6 enable its efficient SUMOylation of genome maintenance proteins
dlvr.it
Multi-subunit collaboration enables Smc5/6 to function as a composite SUMO E3 complex - Nature Communications
SUMO ligases conjugate the SUMO modifier to target proteins, thus regulating their functions. Here, the authors reveal how DNA and ATP binding by the multiple subunits of the SUMO ligase complex Smc5/6 enable its efficient SUMOylation of genome maintenance proteins.
