A single administration of the psychedelic drug 25CN-NBOH repairs synaptic physiology and intrinsic excitability of prefrontal cortex layer 5 (L5) pyramidal cells in adolescent mice following prenata...

Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexib...

Psychedelic drugs have shown therapeutic potential for the treatment of multiple neuropsychiatric disorders chiefly by promoting long-lasting plasticity in the prefrontal cortex (PFC). A critical func...

Classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2A receptors (5-HT2ARs). Here, we instead find that multiple classe...