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Takeshi Sawada @tsawada.bsky.social · 13/11/2025

Huge thanks to Haruo Kasai, Siqi Zhou, and all our wonderful collaborators who made this work possible!

Takeshi Sawada @tsawada.bsky.social · 13/11/2025

It also induced a unique, intermittent non-wake/non-sleep “State-C,” marked by behavioral arrest and reduced γ-power, without major δ changes. Together, these findings suggest that associative spine enlargement is critical for sustaining cortical processing and wakefulness.

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Takeshi Sawada @tsawada.bsky.social · 13/11/2025

Interestingly, broad induction of SynC in the frontoparietal cortex caused acute deficits in goal-directed behaviors (e.g., laser-dot chasing). The firing rates of cortical neurons were largely unchanged, but pairwise correlations between neurons decreased.

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Takeshi Sawada @tsawada.bsky.social · 13/11/2025

Induction of SynC in the primary motor cortex impaired motor learning.

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Takeshi Sawada @tsawada.bsky.social · 13/11/2025

Following our synaptic-potentiation tool SYNCit-K published last year (www.science.org/doi/10.1126/...), we have now developed SYNCit-C (SynC), which selectively and reversibly blocks associative dendritic-spine enlargement while leaving basal synaptic transmission and neuronal excitability intact.

science.org

Prefrontal synaptic regulation of homeostatic sleep pressure revealed through synaptic chemogenetics

Sleep is regulated by homeostatic processes, yet the biological basis of sleep pressure that accumulates during wakefulness, triggers sleep, and dissipates during sleep remains elusive. We explored a ...

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Takeshi Sawada @tsawada.bsky.social · 13/11/2025

Excited to share our new preprint: Blockade of associative spine enlargement impairs awake cortical function biorxiv.org/content/10.1...

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Reposted by Takeshi Sawada

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 08/11/2025

Blockade of associative spine enlargement impairs awake cortical function www.biorxiv.org/content/10.1101/202…

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