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Tyler Inskeep (they/them)

@trinskeep.bsky.social
39 followers 56 following 5 posts

PhD candidate in the Groen Lab @ UC Riverside. evolutionary systems biology, plant development, root-knot nematodes. they/them

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Reposted by Tyler Inskeep (they/them)
Genome Biology and Evolution @genomebiolevol.bsky.social · 05/08/2026
@trinskeep.bsky.social & @simoncgroen.bsky.social link genome-wide gene expression to lifetime fecundity in C. elegans, suggesting that genome structure and network topology jointly shape how variation in gene expression translates into fitness. 🔗 doi.org/10.1093/gbe/evag180 #societyjournal
GBE | Network Properties Influence Covariance Between Gene Expression and Fecundity Fitness of Caenorhabditis elegans in a Novel Laboratory Environment

Caenorhabditis elegans hermaphrodite overlaid with a gene regulatory network. The illustration highlights the relationship between network architecture and expression-fitness covariance described in the study. Illustration by Tyler Inskeep, based on an organismal silhouette accessed from PhyloPic, with the license CC0 1.0 "Universal Public Domain".
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Reposted by Tyler Inskeep (they/them)
Jeff Groh @jeffgroh.bsky.social · 28/07/2026
Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...
pnas.org
Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS
In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...
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Reposted by Tyler Inskeep (they/them)
Evolution Letters @evolletters.bsky.social · 11/05/2026
How do generalist parasites stay adaptable across many hosts? Root-knot nematodes show balancing selection maintaining host-specific variation in key pathogenicity genes. academic.oup.com/evlett/advan... Image Wikimedia
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Reposted by Tyler Inskeep (they/them)
Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 11/08/2025
🔥my latest paper from @odedrechavi.bsky.social lab🔥 we found small RNAs act across tissues to regulate fertlity in C. elegans 🪱. Surprisingly, we also found that O2-sensing neurons inhibit germline maintenance. Follow along our journey👇https://www.biorxiv.org/content/10.1101/2025.08.07.669182v1
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Reposted by Tyler Inskeep (they/them)
Matthias Benoit @mattbnt.bsky.social · 05/03/2025
🚨New paper published in @nature.com! Using pan-genetics across the Solanum genus🍅🥔🍆we reveal why gene duplications🧬are major contingencies in crop engineering. My postdoc work in the Lippman lab @CSHL, collab. with @katiejenike.bsky.social @mikeschatz.bsky.social chatz.bsky.social and many others!
nature.com
Solanum pan-genetics reveals paralogues as contingencies in crop engineering - Nature
Gene duplication and subsequent paralogue diversification are major obstacles to genotype-to-phenotype predictability.
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Tyler Inskeep (they/them) @trinskeep.bsky.social · 26/02/2025
🚨 excited to share that my first, first author manuscript is now accessible on biorxiv! in it, my mentor @simoncgroen.bsky.social and I explore how gene expression evolves in real time in C. elegans, leveraging an incredible dataset from Erik Andersen’s group! www.biorxiv.org/content/10.1...
biorxiv.org
Network properties constrain natural selection on gene expression in Caenorhabditis elegans
Gene regulatory networks (GRNs) integrate genetic and environmental signals to coordinate complex phenotypes and evolve through a balance of selection and drift. Using publicly available datasets from...
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