Talquetamab continued to demonstrate high overall response rates in heavily pretreated patients with relapsed or refractory multiple myeloma with longer follow-up in this post-hoc analysis. Overall re...

MicroabstractOur study evaluated the efficacy and safety of reduced-dose melphalan (Mel140) versus high-dose melphalan (Mel200) in 233 multiple myeloma patients undergoing first autologous stem cell t...

MicroabstractOur study evaluated the efficacy and safety of reduced-dose melphalan (Mel140) versus high-dose melphalan (Mel200) in 233 multiple myeloma patients undergoing first autologous stem cell t...

Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of patients with relapsed/refractory (R/R) hematologic malignancies, including B-cell lymphomas and multiple myeloma (MM...

In less than a decade since their first approval, chimeric antigen receptor T-cell (CAR-T) therapies have moved into earlier lines of therapy, shifting administration from an inpatient to an outpat...

Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

Key PointsD-R maintenance improved MRD-negative conversion rate in patients with NDMM who were MRD-positive after transplant vs R maintenance.PFS favored D

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case o...

According to the Surveillance, Epidemiology, and End Results Program registry, approximately 36,000 patients are annually diagnosed with multiple m...

Key Points. High sBCMA and high MTV predict for inferior outcomes and increased severity toxicities in RRMM treated with anti-BCMA CAR-TDiscrepant results

This study examines the impact of cytogenetic abnormalities and their co-segregation on the prognosis of newly diagnosed multiple myeloma patients. The analysis included 1304 patients from four diffe...

Readers will never think the same way again about games, horses and spies

Martin Puchner’s new book is a forceful rebuke to those who argue that culture can be owned by groups, nations, religions or races.

An archaeologist and an anthropologist dismantle received wisdom about the way early societies operated

Over thousands of years humans domesticated themselves

Despite tremendous advancements in multiple myeloma (MM) therapeutics, outcomes remain heterogeneous, heavily influenced by clinical and cytogenetic f…

Former HHS Secretary Tom Price writes that the new Trump administration should update immigration laws to help the U.S. health care workforce crisis.

Obecabtagene autoleucel (obe-cel) is an autologous 41BB-ζ anti-CD19 chimeric antigen receptor (CAR) T-cell therapy which uses an intermediate-affinity CAR to reduce toxic effects and improve persis...