Signal Transduction and Targeted Therapy - Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment

Different agonists produce equilibria of at least four distinct active states of the G-protein-bound M2 muscarinic acetylcholine receptor, each with a different ability to activate G proteins.

Pape et al. link the CD5-CK2-STAT3 signalling pathway to both inflammation and effector function in multiple sclerosis, using a multi-modal approach that c