What if the stuff attached to tau fibrils affect their pathogenic structure? We found that repositioning polyubiquitin remodels pathological tau filaments, linking PTMs to tau strain biology. Huge credit to Dr. Ryohei Watanabe for leading this work.
www.nature.com/articles/s41...
nature.com
Repositioning of polyubiquitin alters the pathologic tau filament structure - Nature Structural & Molecular Biology
Watanabe et al. show that tau fibrils from Alzheimer disease and vacuolar tauopathy exhibit distinct seeding patterns in vivo. Cryo-electron microscopy reveals that modifications outside the ordered c...
