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Tiago C. Luís

@tiagocluis.bsky.social

135 followers 160 following 7 posts

Group leader @imperialcollegeldn.bsky.social. We investigate how blood stem cells are regulated by their microenvironment during regeneration and leukemia initiation

Posts Replies Media

Tiago C. Luís @tiagocluis.bsky.social · 26/05/2026

Congrats. Looking forward to read.

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Tiago C. Luís @tiagocluis.bsky.social · 21/10/2025

Looking for a PhD on stem cells, microenvironment and gene regulation/alternative splicing. Join us for this great project with @whatchamacaulay.bsky.social

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Reposted by Tiago C. Luís

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 25/09/2025

Packed house for the kickoff at #ISEH2025 🏯 this morning! We are excited to have you all join us here in Kumamoto.

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Tiago C. Luís @tiagocluis.bsky.social · 21/07/2025

Huge congratulations to Marine Sechi for leading the work, which was a joint effort with the Lo Celso lab. Many thanks to all our other collaborators for their contributions and support. @imperialimmuno.bsky.social @imperialcollegeldn.bsky.social

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Tiago C. Luís @tiagocluis.bsky.social · 21/07/2025

While in homeostasis Hoxb5+Vwf+ HSCs are not found in closer proximity to megakaryocytes, high megakaryopoiesis dynamics following platelet depletion leads to increased proximity to megakaryocytes, revealing previously unrecognized niche dynamics in HSC regulation during regeneration.

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Tiago C. Luís @tiagocluis.bsky.social · 21/07/2025

Intravital microscopy showed that Hoxb5+Vwf+ HSCs have a non-migratory behaviour in all situations investigated and independently of the proliferative state of HSCs.

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Tiago C. Luís @tiagocluis.bsky.social · 21/07/2025

Co-expression of Hoxb5-mKO2 and Vwf-GFP alone defines a population of cells highly enriched for hematopoietic stem cells. This double reporter strategy is stable in homeostasis, stress and ageing.

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Tiago C. Luís @tiagocluis.bsky.social · 21/07/2025

New Preprint 🚨. Our latest work is now available in biorXiv: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche. www.biorxiv.org/content/10.1...

Immunofluorescence image of and Hoxb5+Vwf+ and an Hoxb5+Vwf- cells in the bone marrow niche

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Reposted by Tiago C. Luís

Invisible Warrior_SCD @inviswarriorscd.bsky.social · 08/06/2025

We are back @ExRdFestival today! Test your pipetting skills (in our custom lab coats!), learn about #SickleCell with our quiz, see real blood cells through a microscope, or craft a message for #SCDwarriors at our art table: www.imperial.ac.uk/immunology-i...

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Reposted by Tiago C. Luís

Mick Milsom @milsommick.bsky.social · 05/02/2025

New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC

doi.org

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

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