The world is rapidly aging. It is projected that the “young old” (i.e., 60+ y) population will double by 2050 and the “older old” (i.e., 80+ y) will n…

The population of older Americans is expanding rapidly and is expected to double by 2060. While people are living longer than ever, many are also living with chronic health problems that impact their ...

Aim: The purpose of this study was to investigate the sex-specific differences in how late-midlife adults respond to short term disuse and rehabilitation. Methods: Sixteen, late-midlife adults, who we...

The risk for developing insulin resistance and type II diabetes increases with age. Although lifestyle factors contribute to age-related insulin resistance, aging itself independently reduces insulin ...

We investigated how short-term muscle disuse altered the skeletal muscle metabolome, lipidome and transcriptome in middle-aged adults. We report that the energy metabolism pathways: Nicotinate and nic...

A chronic increase in mTORC1 signaling is implicated in reduced longevity, altered metabolism, and mitochondrial dysfunction. Abnormal mTORC1 signaling may also be involved in the etiology of sarcopen...

Sarcopenia increases the risk of frailty, morbidity, and mortality in older adults. Resistance exercise training improves muscle size and function; however, the response to exercise training is variab...