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theidealhuman.bsky.social

@theidealhuman.bsky.social
4 followers 2 following 127 posts
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theidealhuman.bsky.social @theidealhuman.bsky.social · 11/12/2024
which people do u follow?
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theidealhuman.bsky.social @theidealhuman.bsky.social · 08/12/2024
4) btw cell fusion has been used to fertilize an egg while preserving sperm organelles, which leads to surprising non DNA based inheritances with consequences
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theidealhuman.bsky.social @theidealhuman.bsky.social · 08/12/2024
3) en.wikipedia.org/wiki/Hybrido... Cell fusion has multiple roles in healthy humans, from organogenesis to tissue repair, and can be a advantage for tumors pubmed.ncbi.nlm.nih.gov/27136533/ most cell to cell fusions instances in adulthood are unknown because the topic is unknown hence understudied
en.wikipedia.org
Hybridoma technology - Wikipedia
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theidealhuman.bsky.social @theidealhuman.bsky.social · 08/12/2024
2) because this has permanent consequences (dna integration, organelles inheritance, etc) Fusion can also be used in the lab to immortalize a cell that produce a given protein. Historically this has only been used for antibodies production, but in theory it could be used to produce any protein
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theidealhuman.bsky.social @theidealhuman.bsky.social · 08/12/2024
Cell to cell fusion is distinct from tunnelling nanotube, extracellular vesicles and endocytosis exchanges of material between cells. (I am not familiar with tunnelling nanotube research btw) Cells do fuse together, the actual rate and relevance is unknown but probably relevant because
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theidealhuman.bsky.social @theidealhuman.bsky.social · 08/12/2024
there is also the understudied question of cell to cell fusion
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theidealhuman.bsky.social @theidealhuman.bsky.social · 28/11/2024
That's kinda the plot of this horror manga: www.instagram.com/manga.tetsu/...
instagram.com
Tetsu on Instagram: "𝗧𝗵𝗲 𝗯𝗶𝘁𝘁𝗲𝗿𝘀𝘄𝗲𝗲𝘁 𝗲𝗻𝗱𝗶𝗻𝗴 𝗼𝗳 𝗨𝘇𝘂𝗺𝗮𝗸𝗶 Manga: Uzumaki You all know I'm a big fan of Junji Ito's work. But Uzumaki surpass every other horror manga I've ever read. Especially the dist...
770 likes, 16 comments - manga.tetsu on October 26, 2023: "𝗧𝗵𝗲 𝗯𝗶𝘁𝘁𝗲𝗿𝘀𝘄𝗲𝗲𝘁 𝗲𝗻𝗱𝗶𝗻𝗴 𝗼𝗳 𝗨𝘇𝘂𝗺𝗮𝗸𝗶 Manga: Uzumaki You all know I'm a big fan of Junji Ito's work. But Uzumaki surpass every other horror man...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 28/11/2024
The most potent T cell upregulator is thymalin btw
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theidealhuman.bsky.social @theidealhuman.bsky.social · 26/11/2024
global warming empirically shows a deficit in raining globally
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theidealhuman.bsky.social @theidealhuman.bsky.social · 25/11/2024
While the beta lactam selectivity in theory should make beta lactams have low eukaryotic cytotoxicity, in practice for unclear reasons that is far from the case. Beta lactams induce significant oxidative stress which is lower in some other classes. BTW humans have beta lactam proteins but niche role
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theidealhuman.bsky.social @theidealhuman.bsky.social · 25/11/2024
The field and translational state of antibiotic research is in a very poor state. It is criminal that nobody is attempting a dumb lipophillic version of fusidic acid in order to considerably improve cure rates AND reduce antibiotic resistance pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Reversing the Natural Drug Resistance of Gram-Negative Bacteria to Fusidic Acid via Forming Drug–Phospholipid Complex
Drug resistance substantially compromises antibiotic therapy and poses a serious threat to public health. Fusidic acid (FA) is commonly used to treat staphylococcal infections, such as pneumonia, oste...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 24/11/2024
2) Also even if the universe is black per se, the total flux of light is 100% in excess of what is predicted arxiv.org/abs/2203.11236
arxiv.org
The cosmic optical background excess, dark matter, and line-intensity mapping
Recent studies using New Horizons LORRI images have returned the most precise measurement of the cosmic optical background to date, yielding a flux that exceeds that expected from deep galaxy counts b...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 24/11/2024
There are multiple alternative explanations to the olber paradox, the main one being tired light. BTW the main competing expanding universe cosmology nowadays are rh=ct and coasting expansion
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
how do those percentages compare to an equal weight loss induced through mere caloric restriction?
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
btw D-ribose is underatted in bioenergetics and even more so is the ultimate discovery of the century: Skq1
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
the mitochondria fuel ratio research is a mess. ALCAR is very interesting but so is its inhibitor: meldonium wether improving glucose versus lipid oxidation is preferable is far from clear. specifically for cardioproection meldonium should be better though
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
interesting!
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
hlahore.substack.com/p/48-x-more-... vit d does not lower cardiac mortality but wonder if it does on emergencies
hlahore.substack.com
4.8 times more likely to die within 28 days of entering ICU if low Vitamin D
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
Vitamin D does not reduce CV mortality but does reduce all cause mortality pubmed.ncbi.nlm.nih.gov/37111028/ moreover those trials are limited by their durations, some effects even if rare, can accumulate over the whole lifespan
pubmed.ncbi.nlm.nih.gov
Vitamin D Supplementation and Its Impact on Mortality and Cardiovascular Outcomes: Systematic Review and Meta-Analysis of 80 Randomized Clinical Trials - PubMed
The emerging results of our meta-analysis present evidence that vitamin D supplementation appears to decrease the risk of ACM (especially convincing in the fair- and good-quality RCTs), while not show...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
there are countless benefits of vitamin D vitamindwiki.com
vitamindwiki.com
VitaminDWiki | VitaminDWiki
Science-based Vitamin D
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
iirc SLGT2i are better here
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
the insane cost-benefit of glp1 to society must be compared to alternatives such as pubmed.ncbi.nlm.nih.gov/29641571/
pubmed.ncbi.nlm.nih.gov
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized doub...
Clinicaltrials.gov NCT01443780.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
RCTs are often inferior to observational studies, it is not intuitive but well eplained in the literature
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
Extremely interesting, I wonder if this included neurofilament light chain. BTW you might be interested in this study pubmed.ncbi.nlm.nih.gov/29641571/
pubmed.ncbi.nlm.nih.gov
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized doub...
Clinicaltrials.gov NCT01443780.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 23/11/2024
There was a recent study though about cardiac atrophy. BTW here is one of the most interesting study in cardiology pubmed.ncbi.nlm.nih.gov/29641571/
pubmed.ncbi.nlm.nih.gov
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized doub...
Clinicaltrials.gov NCT01443780.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
Where is the interview? also take a look at this www.researchgate.net/publication/...
researchgate.net
(PDF) An investigation into the WIV databases that were taken offline
PDF | Slideshow version: bit.ly/3nF01M9 (slightly more up to date). On the 12th Sep 2019, the main database of samples and viral sequences of the Wuhan... | Find, read and cite all the research you ne...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
The most underlooked paradigm shift in climatology is that CO2 alter plants evapotranspiration and cloud seeding via terpenoid synthesis upon drought stress. The consequence is the observed reduction in cloud cover worldwide and the increase in water vapour, the biggest GHG
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
One also cannot ignore the role of decreased cloud cover and increased water vapor observed over decades spj.science.org/doi/10.34133... The true cause of those changes require knowledge in phytochemistry and cloud nucleation
spj.science.org
Increase in Tropospheric Water Vapor Amplifies Global Warming and Climate Change | Ocean-Land-Atmosphere Research
Among the greenhouse gases (GHGs), atmospheric water vapor is the most abundant, has a large influence on the radiation budget of Earth, and plays a decisive role in regional weather processes. We inv...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
still no community for cosmology?
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
It is a mistake to believe that I consider myself as perfect or as all knowing, the notion of erudition and rationality is 100% relative, meaning that instead of being a megalomaniac you should better see me as a misanthrope
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
People are simply extremely ignorant of the topic, if you actually read Wuhan lab papers you will find many hints how what actually happened. The most enlightening fraud is clarified here www.researchgate.net/publication/...
researchgate.net
(PDF) An investigation into the WIV databases that were taken offline
PDF | Slideshow version: bit.ly/3nF01M9 (slightly more up to date). On the 12th Sep 2019, the main database of samples and viral sequences of the Wuhan... | Find, read and cite all the research you ne...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
2) we should be able to reduce this lethality without reducing vaccine effectiveness. It probably is quite trivial through e.g. coadministration of antioxidants or checking baseline biomarkers
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
If you consider the VAERS data as false you are in reality denial. The objectivity of those people is off topic to such basic findings. Also yes vaccines can be a leading cause of sudden infant death and still be a net benefit for small children. However through careful pharmacokinetics we should
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
3) or through falsifying the data. However as you can see in this study the researcher does nothing even if he was fraudulent he could not change the conclusions because this scientific study is not a study, it is merely a dumb query on the VAERS database which is public gov data.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
2) For example the most common fraud in medecine is to publish or not publish a result dependently on wether the conclusions are within the interest (only 1/3 of completed clinical trials are published which is insane). Or one would falsify the study design either through subtle methods or
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
What does it tell? Moreover shallow dismissals must need to make sense. One cannot simply output statements without coherence and meaning. Hence even if we were to assume there is a conflict of interest with the researcher, you'd have to explain how this conflict could affect the conclusions
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
With all due respect this opinion is empirically falsified. Yes most of transmission is genetically based and there is probably low or no transmission of acquired charachteristics in humans. But it is undeniably proven and reproduced countless time in rodents, plants en.wikipedia.org/wiki/Transge...
en.wikipedia.org
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
Of course but this cannot happen, people are 1) too ignorant 2) have too short attention spans 3) are not trained at rationalit, cognitive biases and logical fallacies 4) tribes For example, how confident are you that ivermectin is effective or ineffective for Covid. Same question for paxlovid.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
Vaccination and sudden death in small children are extremely collocated > 78.3 % occurred within 7 days post-vaccination, confirming that infant deaths tend to occur in temporal proximity to vaccine administration. pubmed.ncbi.nlm.nih.gov/34258234/
pubmed.ncbi.nlm.nih.gov
Vaccines and sudden infant death: An analysis of the VAERS database 1990-2019 and review of the medical literature - PubMed
Although there is considerable evidence that a subset of infants has an increased risk of sudden death after receiving vaccines, health authorities eliminated "prophylactic vaccination" as an official...
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
So here is the takeway, by attempting at dismissal and censorship of new contra narrative signals, the strategy backfire (streisand effect, etc). Actually engaging with new controversial evidence would ironically reduce the prevalence of distrust in science and complotism.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
Trust in scientists will keep lowering as will their credibility. New empirical evidence about controversial topics is continuously suppressed, through dishonesty, statistical tricks or plain fraud (e.g. fluoride neurotoxicity, ivermectin). Until we do better the trend will grow.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
3) there is also the underappreciated matter of cell to cell fusion! regardless, at least in non humans, epigenetic inheritance exist and has many important roles, including e.g. vernalization. Moreover besides the topic of transmission, dynamic regulation of genes is essential during life
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
2) matters. Moreover the foetus is contaminated by foreign mother cells and the mother is contaminated by foetal stem cells, for the rest of their lifetime actually. Moreover lymphocytes B from the mother enter the foetus and have extreme "epigenetic" ability via the VDJ.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
I did not read the posts fully but I suppose you will actually start to defend the inheritance of acquired charachteristics in the next 3 posts. Crucially one has to answer how it actually happens, wether the maternal epigenome has partial transfer, wether information contained in maternal organeles
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
What would you say are the strongest points for and against the lab leak hypothesis?
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
I consider myself as the most erudite polymath on the net, feel free to ask me anything, I shall give you a glimpse of how reality is more complex than any mainstream narrative can appreciate. It truly is magnificent every science is full of surprise and ignoring them will lead us to our demise
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
Is the substack rationalist diaspora on Bluesky already? #Rationality #nerd
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
It has to do with gender mostly.
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
Male loneliness and affection deficit is a major problem, brushing it off is extreme apathic behaviour
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theidealhuman.bsky.social @theidealhuman.bsky.social · 22/11/2024
The FDA should be renamed the Federal Death Agency
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