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Siyuan Thaddeus Wu

@thaddeuswu.bsky.social

Applied Mathematician | Biological Mathematics | PhD in Applied Maths @MonashUni | Postdoc @ulfschmitz team | Lecturer @JCU

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Siyuan Thaddeus Wu @thaddeuswu.bsky.social · 02/05/2025

Interested in isoform expression, single-cell analysis, or computational frameworks? Delve into our work at the bioRxiv link.

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Siyuan Thaddeus Wu @thaddeuswu.bsky.social · 02/05/2025

We've confirmed its utility across three distinct biological systems, demonstrating how ScIsoX can identify isoform expression patterns in cell populations and at cell-type-specific levels, and characterise the multidimensional nature of transcriptomic complexity.

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Siyuan Thaddeus Wu @thaddeuswu.bsky.social · 02/05/2025

ScIsoX introduces a novel hierarchical data structure and a comprehensive set of metrics that capture multiple dimensions of isoform expression patterns, revealing insights previously inaccessible with short-read technologies.

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Siyuan Thaddeus Wu @thaddeuswu.bsky.social · 02/05/2025

‼️ ScIsoX: A Framework for Transcriptome Complexity Analysis‼️ In collaboration with Ulf Schmitz (@ulfschmitz.bsky.social), we have developed ScIsoX, the first-ever computational framework specifically designed to characterise transcriptomic complexity in single-cell long-read sequencing data.

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