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Therapeutic Advances in Infectious Disease

@tainfdis.bsky.social
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🦠🚀 High-impact infectious disease research—Rigorous in review, Global in impact. Gold open access and indexed in PubMed, Scopus, and ESCI.

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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 26/09/2026
In hospitalized children with LRTIs, multiplex RT-qPCR detected ≥1 pathogen in 78.5%. Viral-only detection was most common (40.9%), while viral–bacterial co-detection occurred in 26%. Importantly, detection ≠ causation, journals.sagepub.com/doi/full/10....
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Respiratory pathogen detection and Co-detection in hospitalized children with lower respiratory tract infections using multiplex RT-qPCR: A single-center retrospective Observational Study - Yunus Nas, Süveyda Gözüküçük, Bekir Sami Uyanık, Basri Çakıroğlu, 2026
Background Lower respiratory tract infections (LRTIs) are a common cause of pediatric hospitalization, but distinguishing viral from bacterial etiologies based ...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 25/09/2026
TB stigma remains a major barrier to TB control. In this study of 385 patients in Napak district, Uganda, 43.1% reported high perceived stigma. Poor TB knowledge, inadequate social support, and secondary education were associated with higher stigma journals.sagepub.com/doi/full/10....
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Prevalence of perceived stigma and associated factors among patients with tuberculosis in Napak district, Karamoja region, Uganda: A cross-sectional study - Victor Lomonyang, Saadick Mugerwa Ssentongo...
Background Tuberculosis (TB) remains a leading cause of infectious disease mortality globally. Stigma is a critical social determinant that undermines health-se...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 24/09/2026
Mining may be an important occupational risk factor for TB. In a case-control study from Ethiopia (n=735), miners had >3× higher odds of active pulmonary TB (AOR 3.51, 95% CI 1.89–6.50). journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 18/09/2026
New modeling data on RSV prevention in infants: seasonal clesrovimab, particularly with catch-up, was projected to reduce RSV-LRTIs and healthcare costs compared with palivizumab, nirsevimab, and maternal vaccination. journals.sagepub.com/doi/full/10....
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Modeling the potential clinical and economic impact of clesrovimab for the prevention of RSV in infants in England and Wales - Klodeta Kura, Colleen Burgess, Ian R. Matthews, Salisu M. Garba, Dawei Wa...
Background Respiratory syncytial virus (RSV) infects nearly all children under two years, causing mild lower respiratory tract infections (LRTIs) although serio...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 17/09/2026
AMR strategies in LMICs focus on access, stewardship, and surveillance, but overlook whether antibiotic exposure is adequate. Subtherapeutic concentrations can contribute to Rx failure&resistance. TDM-guided dosing may optimize exposure, improve outcomes. journals.sagepub.com/doi/full/10....
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Closing the therapeutic drug monitoring gap: A pragmatic, complementary lever against antimicrobial resistance in low- and middle-income countries - Mamunur Rahman, 2026
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 16/09/2026
Antibiotic resistance is a major challenge in diabetic foot ulcers, particularly in LMICs. This systematic review found high rates of resistance, including MRSA (38.7%), ESBL-producing E. coli (50.7%), and ESBL-producing K. pneumoniae (41.5%). journals.sagepub.com/doi/full/10....
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Bacterial profile and antimicrobial resistance patterns of infected diabetic foot ulcers in low- and middle-income countries: a systematic review and meta‑analysis - Aaron Awere-Duodu, Frederick Kungu...
Background: Diabetic foot ulcers (DFUs) are often polymicrobial infections, necessitating antibiotic therapy. However, the high prevalence of antibiotic misuse ...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 15/09/2026
Drug–drug interactions can shape COVID-19 antiviral prescribing. In this Thai outpatient cohort, statin use was the only independent predictor of choosing molnupiravir over nirmatrelvir/ritonavir (aOR 0.46, 95% CI 0.27–0.79) journals.sagepub.com/doi/full/10....
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Prognostic factors in the selection of antivirals for COVID-19 in high-risk outpatients: A retrospective cohort study - Puttirat Bunditwongpaisan, Natthakit Chavapradit, 2026
Background Early oral antiviral treatment reduced disease progression and hospitalisation in high-risk COVID-19 outpatients. In practice, prescribing decisions ...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 10/09/2026
ALT flares in chronic hep B may signal both immune control and harm. In untreated patients, flares were linked to decompensation, hospitalization, and death; after treatment initiation, they were linked to HBsAg/HBeAg loss without adverse outcomes. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 10/09/2026
New research from Panama explores ART adherence and retention in HIV care. Interviews with PLHIV highlight how daily routines, supportive care, stigma, food insecurity, transportation, side effects, and ART access all shape engagement in care journals.sagepub.com/doi/full/10....
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Managing HIV care in daily life: A qualitative study of ART adherence and retention barriers and facilitators among people attending two urban ART clinics in Panama - Amanda Gabster, Dixennia Bejarano...
Background Optimal antiretroviral therapy (ART) adherence and retention in HIV care are important for viral suppression among people living with HIV (PLHIV). Al...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 03/09/2026
🚨 This systematic review & meta-analysis (7 RCTs, N=3,589) finds that the 2-drug regimen Doravirine/Islatravir (100 mg/0.25 mg) achieves non-inferior viral suppression at 48 weeks journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 01/09/2026
TB + acute intermittent porphyria: a therapeutic tightrope. This case of peritoneal TB highlights severe porphyric crises after HRZE, the challenges of building a safer TB regimen, and the need for individualized, shared decision-making journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 30/08/2026
Toxocariasis and the lung: A systematic review of 65 studies (989 patients) found respiratory manifestations spanning nodules, infiltrates and GGO, with eosinophilia in 89% journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 25/08/2026
High-risk HPV was detected in 65% of MSM with HIV tested in Bamako, Mali—and HPV16 in 12%. Self-collected anal swabs could make HPV screening more accessible in resource-limited settings. journals.sagepub.com/doi/full/10....
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High-risk HPV detection via GeneXpert in self-collected anal swabs among MSM living with HIV: Insights from a cross-sectional study - Amadou Kodio, Almahady Ag Altini, Arè Albert Somboro, Aliou Baldé,...
Background Men who have sex with men living with HIV (MSMLWHIV) have a high risk of persistent high-risk HPV infection, and rapid tools like Xpert HPV can help ...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 14/08/2026
This case-control study identified several factors associated with Visceral Leishmania including 🔹 Dogs in the household 🔹 Acacia trees around the home 🔹 Domestic animals 🔹 No formal education 🔹 Termite hills near the home journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 14/08/2026
🫁 Why does diabetes increase the risk of severe influenza and ARDS? This review delves into the pathogenesis and offers a framework into a bedside approach to immunomodulatory therapy. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 14/08/2026
Cardiac involvement in Burkholderia pseudomallei infection is uncommon, with only a handful of reported cases of cardiac tamponade. This case highlights a rare presentation of melioidosis journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 14/08/2026
In this XDR typhoid study contaminated water, poor sanitation, street-food consumption, season were associated with severe disease. Meropenem and azithromycin showed the highest susceptibility, highlighting the narrow therapeutic options in XDR typhoid. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 14/08/2026
🦠 this review about Human norovirus explores: 🔹 Viral replication & immune evasion 🔹 Emerging antiviral targets and inhibitors 🔹 Vaccine development journals.sagepub.com/doi/full/10....
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Antiviral strategies against human norovirus: Molecular targets, therapeutics, and vaccine development - Sadia Islam, Sabbir Alam Zia, Simonto Mirza, Md Moshiur Rahman, Md Abdullah All Shafi, Md Hamed...
Human norovirus (HuNoV) is a leading cause of acute viral gastroenteritis worldwide and represents a major unmet challenge in antiviral drug and vaccine develop...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 14/08/2026
📊 Rabies prevention in Ethiopia. A systematic review & meta-analysis of 27 studies and 11,964 participants found that only: • 60.4% had good knowledge • 58.6% had favorable attitudes • 54.6% reported good preventive practices journals.sagepub.com/doi/full/10....
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Community awareness, perception, and preventive practices towards rabies in Ethiopia: A systematic review and meta-analysis - Gebremeskel Kibret Abebe, Wagaw Abebe, 2026
Background Rabies is a major global public health problem, with case fatality rate approaching 100% once clinical symptoms appear, causing severe neurological c...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 05/08/2026
In a small cohort of hospitalized, moderately to severely immunocompromised patients with COVID-19, ensitrelvir was associated with low 28-day mortality, with outcomes comparable to remdesivir. Larger prospective studies are needed. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 05/08/2026
Adjunctive corticosteroids in non-HIV PJP remain controversial. This systematic review & meta-analysis suggests the highest-quality evidence comes from the lone RCT, supporting benefit in severe disease while underscoring the need for more trials. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 02/08/2026
Among PLHIV with virologic failure in North-Eastern Uganda, 18.7% had dolutegravir resistance. Poor adherence, NRTI resistance, longer DTG use, and substance abuse were key risk factors. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 26/07/2026
How should infectious diseases specialists use general-purpose LLMs safely and responsibly? This protocol outlines expert consensus on the principles, opportunities, limitations, and stewardship considerations for LLM use in clinical microbiology and ID. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 26/07/2026
Magnusiomyces clavatus is an emerging cause of invasive fungal infection in immunocompromised patients. This case reports successful treatment of pediatric M. clavatus fungemia journals.sagepub.com/doi/full/10....
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Magnusiomyces clavatus fungemia treated with combination antifungals including isavuconazole in an immunocompromised pediatric patient: a case report - Amanda Z. McPherson, Matthew Miller, Kacie Rytle...
Magnusiomyces clavatus, formerly Saprochaete clavata or Geotrichum clavatum, is an ascomycetous yeast found in the environment as well as the gastrointestinal a...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 24/07/2026
Case report describes a 9-year-old girl with severe malnutrition who developed biliary obstruction, pancreatitis, and cholestasis due to Fasciola spp., with concurrent Ascaris lumbricoides infection journals.sagepub.com/doi/full/10....
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Chronic Fasciola hepatica infection in a patient with cutaneous visceral loxoscelism: paediatric case report - Blanca Salazar-Mesones, Laura Melissa Mori-Llontop, Alfredo Chiappe-Gonzalez, Claudia Laz...
We present the case of a 9-year-old girl from the Peruvian Andean Region (Ancash), diagnosed with fascioliasis, who was also suffering from severe malnutrition....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 24/07/2026
Analysis of 67,134 children from 11 sub-Saharan African countries found that 31% of children under 5 experienced acute respiratory infections. Wasting, air pollution increased prevalence.Wealth, health delivery, media were associated with lower prevalence. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 24/07/2026
A study from Uganda found 12.6% HCV seroprevalence among patients with sickle cell disease, most of whom had a history of blood transfusion. highlights the need for HCV screening, improved linkage to care, and continued strengthening of transfusion safety. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 22/07/2026
The Asian tiger mosquito (Aedes albopictus) continues to expand its footprint. New findings from Magdalena, Colombia underscore why ongoing vector surveillance is essential to detect emerging risks for dengue and other arboviral diseases. 🦟🌎 journals.sagepub.com/doi/full/10....
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Aedes albopictus in the department of Magdalena, Colombia: spread to the northernmost of the country and implications for arboviral disease transmission - Erik Perdomo-Balaguera, Katiuska Ariza-Campo,...
Background: Aedes albopictus is widely distributed throughout the world. It was introduced into the Americas in 1985 and has been incriminated as secondary vec...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 17/07/2026
New data on aortic endograft infection: among 46 patients,63% presented late, S. aureus was the leading cause,blood cultures +Ve in just 54%.Surgical & medical Rx had similar overall success, but medical therapy alone was associated with more relapses. journals.sagepub.com/doi/full/10....
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Clinical presentation, management, and outcomes of aortic endograft infections: a retrospective descriptive study - Haitham Alaithan, Sarwat Khalil, Gustavo Oderich, Larry M. Baddour, Muhammad Rizwan ...
Background: Aortic endograft infection (AEGI) is a rare complication of abdominal endovascular aortic repair (EVAR) and thoracic endovascular aortic repair (TEV...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 07/07/2026
What is driving the evolving HIV epidemic in Bangladesh? This review synthesizes a decade of evidence on epidemiology, prevention, treatment, and structural barriers to inform the path forward. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 01/07/2026
Why do some people develop TB while others don't or respond differently to treatment? This pilot study from Panama suggests that host genetics, specifically the VDR BsmI polymorphism, may influence vitamin D status and immune responses in pulmonary TB. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 25/06/2026
Can we predict which liver transplant recipients will develop early intra-abdominal infections? Cao et al. developed and externally validated interpretable ML models (LIFT) that outperformed MELD and CTP scores, enabling personalized risk stratification journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 17/06/2026
🚀📈New milestone! Excited to share that our Journal Impact Factor has risen to 3.8🎉This achievement reflects the contributions of our authors,reviewers,editors,&readers. Thanks for being part of our community! We look forward to advancing ID through impactful research✨
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 17/06/2026
New nationwide data from Belize show a concerning AMR burden: 41.5% of urinary Enterobacterales isolates were resistant to both ciprofloxacin and TMP-SMX, with high MDR rates even in outpatients. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 16/06/2026
Persistent pneumothorax in pulmonary TB doesn't always require surgery. In a patient with extensive TB and severe HBV flare, tailored medical management led to complete resolution and recovery. Read more @ journals.sagepub.com/doi/full/10....
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Secondary spontaneous pneumothorax due to extensive pulmonary tuberculosis in a patient with acute hepatitis B flare: clinical challenges and therapeutic decision making—a case report - Loi Trinh Duc,...
Secondary spontaneous pneumothorax (SSP), particularly when complicated by a persistent air leak, is an uncommon but serious manifestation of active pulmonary t...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 16/06/2026
Persistent pneumothorax in pulmonary TB doesn't always require surgery. In a patient with extensive TB and severe HBV flare, tailored medical management led to complete resolution and recovery. Read more @ journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 12/06/2026
Geospatial targeting of TB screening in Uganda reduced screening volume by 92%, increased TB yield by 10%, and cut costs by >90%. Surveillance data can help find more TB with fewer resources journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 29/05/2026
Neonatal sepsis remains alarmingly common in Ethiopia: pooled prevalence 29.9%, with 66.2% multidrug resistance. Klebsiella pneumoniae and E. coli predominated, showing high resistance to first-line antibiotics. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 27/05/2026
Adult HBV vaccination decisions are shaped not only by access barriers, but also by culturally embedded beliefs. Context-sensitive education + provider recommendations are key journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 25/05/2026
Do all patients with CIED infection need prolonged antibiotics? In this cohort, ≤2 weeks of therapy AFTER device extra extraction had similar mortality and recurrence rates compared with longer courses after complete device removal. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 25/05/2026
Late-onset CMV pneumonia can occur even 1 year after auto-HSCT, particularly in patients with profound CD4 lymphopenia. This case highlights the value of immune-guided surveillance and BALF mNGS in diagnosing complex infections in immunocompromised hosts. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 25/05/2026
Scrofuloderma can mimic hidradenitis suppurativa and other chronic skin diseases. This case highlights the need to consider TB in atypical recurrent skin lesions journals.sagepub.com/doi/full/10....
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Cutaneous tuberculosis with features suggestive of scrofuloderma masquerading as hidradenitis suppurativa: a case report - Midhun Raj, Tarun Kumar Suvvari, Vimal Thomas, Anand Krishnan R. G., Aishwary...
Scrofuloderma is a form of cutaneous tuberculosis that results from the spread of infection from an underlying focus, most commonly lymph nodes or bone, to the ...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 21/05/2026
Among graduating healthcare students at Debre Tabor University: 💊 68% bought antibiotics without a prescription 🧠 Only 32.5% recognized antimicrobial stewardship (AMS) Knowledge alone isn’t enough journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 21/05/2026
In a cohort from Gulu City, 45.4% experienced viral non-suppression, driven by poor ART adherence, delayed HIV disclosure, advanced disease, young age, and economic hardship. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 07/05/2026
New systematic review & meta-analysis in SSA HCWs shows moderate AMR knowledge (65%) and attitudes (69%), but weaker practices (54%), with a clear knowledge–practice gap—most evident among doctors (knowledge 65%, practice 43%). journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 01/05/2026
TB treatment is evolving—but persistence remains a major barrier. New evidence shows macrophage metabolism and redox state shape intracellular drug tolerance in Mtb. Host-directed strategies may enhance antibiotic efficacy and help shorten therapy ⏳ journals.sagepub.com/doi/full/10....
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Targeting macrophage metabolic checkpoints: a host-directed strategy to overcome drug tolerance in tuberculosis - Tarun Kumar Suvvari, Sridhar V. N. S. Kocharlakota, Venkataramana Kandi, 2026
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 27/04/2026
Case report: a young patient with years of “chronic lung disease” ultimately diagnosed with aggressive HTLV-1 driven lymphoma-fatal within weeks. Early biopsy + T-cell panel (CD4+CD25+ with CD7 loss) should trigger HTLV-1 testing, regardless of geography. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 27/04/2026
CKD and UTIs form a vicious cycle: kidney dysfunction increases infection risk ; while recurrent UTIs accelerate renal decline. Breaking this loop demands early CKD detection, antimicrobial stewardship & non-antibiotic prevention strategies. journals.sagepub.com/doi/full/10....
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 22/04/2026
Neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are valuable, readily available markers for gauging severity in community-acquired pneumonia 🦠📊 journals.sagepub.com/doi/10.1177/...
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Assessing pneumonia severity using neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: a cross-sectional comparison with CURB-65 score - Muhammad Osama, Ahmad Iftikhar, Mallahat Abdul Baseer, ...
Background: Community-acquired pneumonia continues to be a leading cause of morbidity and mortality worldwide. Several validated scoring systems are available f...
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Therapeutic Advances in Infectious Disease @tainfdis.bsky.social · 22/04/2026
CKD and UTIs form a dangerous feedback loop 🔁: impaired immunity and structural changes drive recurrent, often MDR infections, which in turn hasten kidney decline. Prevention, early detection, and stewardship are central to breaking the cycle journals.sagepub.com/doi/full/10....
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