This cohort study investigates the association of adjuvant chemotherapy following resection of pancreatic adenocarcinoma after preoperative FOLFIRINOX in full or modified dosing with overall survival,...

The aim of this study is to investigate the role of maximum standardized uptake and tumor-to-liver ratio derived from preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomograp...

The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.

Introduction Cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) candidates often have extraperitoneal abdominal disease. Current expert peritoneal surface malignancy (PSM) gui...

Background Early diagnosis of metastases is crucial but routine staging with contrast-enhanced multidetector computed tomography (ceMDCT) is suboptimal. A total of 20% will have indeterminate or too s...

Background Tumor microvasculature is an important component of the tumor microenvironment (TME), and it has been reported that tumor microvasculature induces TME to become immunosuppressive via vascul...

Background Rectal tumors display varying degrees of response to total neoadjuvant therapy (TNT). We evaluated the performance of a convolutional neural network (CNN) in interpreting endoscopic images ...

Background Pancreaticoduodenectomy (PD) is a complex procedure involving the dissection of the superior mesenteric artery and vein. However, a safe and standardized technique for dissecting the jejuna...

Slow intravenous (iv) hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, taken together, suggest that the...

This is an international survey and case-vignette study including 1283 participants from 55 countries. Interrater variability regarding the ASA classificat

This RCT investigated whether parenchymal pre-compression was effective in reducing pancreatic fistula in distal pancreatectomy. The proportion of patients

Background Select patients with peritoneal metastases are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We assayed for intra- and interpatient drug resp...

Background Frailty, a multidimensional state leading to reduced physiologic reserve, is associated with worse postoperative outcomes. Despite the availability of various frailty tools, surgeons often ...

Background The impact of time to surgery (TTS) on survival in patients with perihilar cholangiocarcinoma (PHC) is uncertain. Methods Data from PHC patients scheduled for surgery between 2011 and 2020 ...

A systematic analysis of clinical trial data uncovers ancestral differences in clinical outcomes, providing insights to advance more precise treatments that are tailored to diverse populations.

Sears and colleagues found that ongoing replication stress pathways and T cell clonal responses differentiate liver and lung recurrence and are associated with different clinical outcomes in the conte...

Tumor-intrinsic subtypes of pancreatic cancer are characterized by distinct kinomes that shed light on subtype-specific vulnerabilities such as receptor tyrosine kinases, including EGFR, in basal-like...

Multiregion-sampled pancreatic cancers representing the full spectrum of clinical presentations reveal distinct genetic differences in pancreatic cancers with indolent features versus those with aggre...

is perceived so high that a recent randomized trial advocated prophylactic total pancreatectomy (TP) as alternative aiming to lower this risk. However, current outcomes of ISGPS-D PD remain unknown as...

Dear Editor,

In this international retrospective cohort study from the Trans-Atlantic Pancreatic Surgery Consortium, the independent prognostic factors for overall surv

Background The prognostic role of the fibrosis-4 (FIB-4) index relative to intrahepatic cholangiocarcinoma (ICC) after hepatectomy remains unclear. This study sought to characterize the impact of the ...

Background Laparoscopic microwave ablation (LMWA) has yet to gain a specific place in treatment guidelines for early hepatocellular carcinoma (HCC). This study compared the outcomes of LMWA and trans-...

Background Gastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resec...

An analysis of published studies suggests that a longer duration of immune checkpoint inhibitor therapy is associated with a higher incidence of complete response among patients with mismatch ...

Annals of Surgical Oncology -

Background Failure to rescue (FTR) is defined as the inability to prevent death after the development of a complication. FTR is a parameter in evaluating multidisciplinary postoperative complication m...

Background Black patients with colon cancer (CC) exhibit more aggressive tumor biology and higher treatment resistance than white patients, even after adjusting for clinical and demographic factors. W...

Kureshi and Dougan discuss the roles of cytokines in the tumor microenvironment. Although there is a sophisticated understanding of cytokine networks, therapeutically targeting cytokine pathways in ca...

Patients with lung-metastatic pancreatic ductal adenocarcinoma survive longer than those with liver metastases. A study now leverages real-world data to identify distinct molecular and immune profiles...

Tumor-intrinsic subtypes of pancreatic cancer are characterized by distinct kinomes that shed light on subtype-specific vulnerabilities such as receptor tyrosine kinases, including EGFR, in basal-like...

Multiregion-sampled pancreatic cancers representing the full spectrum of clinical presentations reveal distinct genetic differences in pancreatic cancers with indolent features versus those with aggre...

Summary:. This study by Treger and colleagues is a comprehensive evaluation of the genome and epigenome of tumors and constitutional tissue from children with Wilms tumor predisposition syndromes that...

Background Multidisciplinary team (MDT) meetings are important but resource-expensive components of surgical and oncologic care. This cohort study investigated the effectiveness of surgical MDT meetin...

Background Lymph node status is a well-established prognostic factor for colon cancer, but the optimal number of nodes for accurate staging remains unclear. This study explored the relationship betwee...

Deleterious DDR gene mutations are associated with improved clinical outcomes in patients with BTC treated with platinum-based chemotherapy or immunotherapy combined with chemotherapy.

This article addresses the growing issue of cancer in developing countries and the disparities in accessing treatments. It underscores the significance of prioritizing global efforts for cancer preve...

Background The association of hospital market competition, financial costs, and quality of oncologic care has not been well-defined. This study sought to evaluate variations in patient outcomes and fi...

Background Neoadjuvant systemic therapy (NAST) for patients with stage III melanoma achieves high major pathologic response rates and high recurrence-free survival rates. This study aimed to determine...

Background Surgical site infections (SSIs) are a common cause of morbidity after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancy. Negative p...

Traditionally, patients with locally advanced rectal cancer undergo neoadjuvant (chemo)radiation, with the goal of downsizing the tumour to facilitate comp

A mural nodule (MN) within branch-duct intraductal papillary mucinous neoplasms (BD-IPMN) could be an excellent target for local treatment. This study, whi

This systematic review reports on outcomes of minimally invasive (MIS-LPJ) and open lateral pancreaticojejunostomy (LPJ) in 1286 patients with symptomatic

Postoperative acute kidney injury is associated with an increase in hospital length of stay and mortality. Intraoperative hemodynamics and fluid management may contribute to acute kidney injury. The a...

Unfavorable intraoperative findings or incidents during minimally invasive liver surgery may necessitate conversion to open surgery. This study aimed to identify predictors for conversion in minimally...

Background Perioperative chemotherapy is the standard treatment modality for locally advanced gastric cancer. However, the efficacy and indication of adjuvant chemotherapy in patients who have already...

Annals of Surgical Oncology -