Nice to step away from spinout updates and highlight an academic collaboration paying off.
Hard working colleague's Refaat Hamed’s work just published in ACS Catalysis: pushing enzyme engineering into some very challenging chemical space.
pubs.acs.org/doi/10.1021/...
pubs.acs.org
Breaking the N-Alkyl Barrier: Enzyme−Substrate Co-Engineering of Fe(II)/2-Oxoglutarate-Dependent Hydroxylases for N-Heterocyclic Amino Acids
Hydroxylation and N-alkylation are powerful, orthogonal handles for modulating the conformation and drug-like properties of amino acid-derived scaffolds, yet doubly substituted, stereodefined N-alkyl ...