In MV COVID-19 ARDS patients, elevated troponin is associated disease severity and poorer ICU survival rather than global systolic dysfunction. In patients with severe LV impairment, troponin may remain a marker of myocardial injury.

Penile prosthesis insertion is recommended for long-duration ischaemic priapism patients with refractory erectile dysfunction. There is a paucity of published data focusing on long term outcomes and quality of life reporting for patients in this setting. We contacted patients who had a post-ischaemi …

Intraoperative administration of TXA is safe and effective in reducing intraoperative blood loss, operative time and postoperative haemoglobin (Hb) drop with resultant decrease in blood transfusion requirements. This meta-analysis did not detect any significant increase in venous thrombosis or risk …

Digital advances for multicentre studies - the British Urology Researchers in Surgical Training (BURST) experience

This ISRC and NSRSC guide provides a practical framework to support investigators in delivering high-quality, compliant, and patient-centred research within the Irish healthcare system.

Decompensated liver cirrhosis shows profound remodelling of serum and IgG N-glycans. These data establish a reference framework for terminal glycomic disruption in liver disease and highlight the potential value of incorporating glycosylation analysis into broader assessments of liver disease progre …

Within the selected group of European sleep clinicians, the clinical value of multi-night sleep testing is broadly recognized, but implementation remains limited by organizational and structural barriers. These findings suggest that sleep medicine may be approaching a stage where the scientific and …

<span><b>Background:</b> Human respiratory exposure to microplastics (MPs) has recently been demonstrated, but their distribution within thoracic tissues and association with lung malignancy remain poorly characterised. We investigated the presence, burden, morphology, and spectroscopic characteristics of</span> …

The unit effectively reduced stress, and national rollout may benefit interns, supporting their transition to medical practice.

This current issue of Hypertension introduces a new series on Board Review questions. After the success of the previous issues dedicated to Board Review,¹^,² the editors of Advances in Kidney Disease and Health are pleased to introduce this new series that will accomp …

The need of preparing guidance is seen, especially for usage dose constraints in occupational exposure. What is more, respondents see the positive aspects of dose constraints, in terms of optimization, safer work environment and risk reduction.

NCT04304963.

This systematic review suggests that GLP-1RAs are associated with improvements in HS severity, quality of life, metabolic and inflammatory parameters, and may additionally reduce healthcare utilization and cardiometabolic risk, observed alongside weight loss. However, current evidence remains limite …

Upadacitinib-Methotrexate Combination Therapy for Refractory Atopic Dermatitis: A Case Series of a Novel Therapeutic Approach

The use of sodium bicarbonate in critically ill patients with metabolic acidosis receiving vasopressors did not lead to a lower risk of major adverse kidney events within 30 days than placebo. (Funded by the National Health and Medical Research Council of Australia; SODa-BIC ClinicalTrials.gov numbe …

ClinicalTrials.gov ID: NCT07110012.

These results support R2 as the strongest static NMDA docking/NMDA-preference benchmark and R14 as the most internally consistent integrated computational candidate. The findings are hypothesis-generating and require synthesis and experimental validation.

The histomorphology-based GvF biomarker predicted differential treatment benefit of first-line GvF. This biomarker can guide optimal treatment selection for first-line therapy in advanced PDAC.

Structured transition programs in IBD can improve engagement of patients with IBD services with significantly lower rates of disengagement with IBD services seen in our study. Large prospective studies are needed in this field to further investigate this and the impact of these programs on disease o …

Black-market weight loss injectables in Hidradenitis Suppurativa: a single-centre survey

A woman in her mid-70s developed uncontrolled intraocular pressure (IOP) in her right eye despite trabeculectomy, Ahmed valve implantation and ongoing topical therapy. Left IOP was normal without treatment. Examination revealed fluffy anterior chamber deposits and vitreous debris. Ultrasound biomicr …

High levels of frailty and frailty-associated morbidity were noted amongst emergency surgical admissions. Collaborative pathways between surgeons and geriatricians may optimise outcomes in this high-risk cohort.

ClinicalTRials.gov: NCT04304963.

This report summarises the key learning points of the first part of the meeting. These discussions set the foundation for defining research priorities and improving early recognition and multidisciplinary care strategies.

Current management strategies across medical, endoscopic, radiological and surgical fields were reviewed, recognising the scarcity of paediatric-specific evidence. Enhanced collaboration, harmonised registries, and standardised study designs were identified as vital next steps towards optimising out …

Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated promising analytical and clin …

PSMA PET/CT May Play a Role in Prostate Cancer Diagnosis in Patients With Equivocal Results on MRI

Experience-based reappraisal of the IBD-DCA histopathological scoring system

ClinicalTrials.gov identifier NCT07211308.

Widespread cortical thinning occurs over the first year of FEP in people not receiving antipsychotics. No such thinning is evident in patients receiving antipsychotics. These findings suggest that cortical thinning in early psychosis is an illness-related phenomenon.

Obesity-associated asthma is an increasingly prevalent and clinically challenging phenotype, characterized by poorer response to conventional asthma therapies, greater disease burden, and a distinct immunometabolic profile that sets it apart from classical eosinophilic asthma. Given the growing inte …

Incidence and distribution of synchronous malignancies in head and neck cancer patients

Automated platforms for quantitative protein biomarker measurement span numerous devices and manufacturers, but multiplex capability remains limited. More standardized device-level reporting would strengthen platform selection for biomarker-enabled trials and future clinical implementation.

The epidemiology of Moraxella species from BCs in Europe showed age-group-specific differences in species distribution and generally favourable antimicrobial susceptibility patterns. Phylogenomic data corroborated recent taxonomic revisions, highlighting the need for improved diagnostics, harmonized …

Mirels remains a useful, accessible, and sensitive first-line screening tool, particularly where plain radiography is the principal imaging modality. CTRA and CT-based FEA may offer additional specificity and objective mechanical information in selected patients where suitable calibrated CT imaging …

Insulin resistance in psoriasis: beyond comorbidity?

Older patients frequently require hospital admission. As chief complaints do not reflect underlying condition or severity, structured evaluation, staff training and geriatric specific care pathways may improve care and reduce adverse clinical outcomes.

A quick start guide for institutional or managed trials; learn how to search for citations, mentions and discover policy and grey literature.

ELX/TEZ/IVA remained generally safe and well-tolerated with no new safety findings. Improvements in lung function, CFTR function, respiratory symptoms, and nutritional status after starting ELX/TEZ/IVA were maintained through 96 weeks of follow-up. These results demonstrate the safety and durable ef …

We provide a roadmap of the entrustment process that trainers and trainees use to give and take the operative autonomy till trainees become independent in RAS training. We also provide concrete teaching and learning strategies that they can use as guidance in their practice.

GLP-1RAs are increasingly incorporated into European sleep practice; however, substantial variability exists in diagnostic timing, PAP management, and follow-up strategies. Harmonised guidance and coordinated multidisciplinary care are urgently needed.

Despite participants' motivations to contribute data to research, engagement was shaped by usability, participant-initiated engagement, and the constraints of living with chronic illness. There is a need for patient-centered design, tailored support, and flexible trial procedures to optimize adheren …

In this study, AVR was associated with substantial reverse remodeling at 7 months, including regression of hypertrophy and a fall in indexed extracellular (matrix) volume; the extracellular volume fraction rose, as cellular regression outpaced matrix regression. Focal scar, as a proportion of myocar …

Adding radium-223 to enzalutamide was associated with faster and more frequent ALP and deep PSA responses. These findings support additional antitumour activity of radium-223 when combined with enzalutamide.

This case highlights the need to consider mpox-associated IRIS in the differential diagnosis of unexplained clinical worsening of mpox in PLHIV who recently initiated ART. Although definitive confirmation of IRIS was not possible because of limited immunological investigations, the temporal associat …