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DBSB_Juntendo / Susaki-lab

@susaki-lab.bsky.social

Dept. Biochemistry and Systems Biomedicine, Juntendo University, Tokyo | Systems biology × 3D spatial biology × Aging | Whole-tissue 3D imaging, Hydra, and 3D/Voxel pathology.

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 08/10/2026

Thank you for introducing our hydra study!

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Genome Biology and Evolution @genomebiolevol.bsky.social · 07/10/2026

Nojiri, @susaki-lab.bsky.social et al. compared the genomes of the immortal Hydra vulgaris and the aging Hydra oligactis. Results suggest that extended lifespan may reflect differences in how core biological processes are organized. 🔗 academic.oup.com/gbe/article/... #societyjournal #genome

GBE | Comparative Genomics Reveals Signatures of Distinct Metabolic Strategies and Gene Loss Associated With Hydra Immortality

An image of Hydra vulgaris strain AEP.JNIG overlaid with the distribution of aging-related genes across the metazoan phylogeny. Yellow dots represent H. oligactis-specific aging-related genes, while the blue dots represent those specific to H. vulgaris.

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Forbes @forbes.com · 26/08/2026

Rasonque joins a short list of treatment options for one of the country’s deadliest types of cancer.

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FDA Approves Pancreatic Cancer Drug That Could Double Survival Time

Rasonque joins a short list of treatment options for one of the country’s deadliest types of cancer.

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

🧬 New paper out in Genome Biology and Evolution! "Comparative genomics reveals signatures of distinct metabolic strategies and gene loss associated with Hydra immortality" The first #Hydra paper from #DBSB, ＃Juntendo , the entrance of #aging reconstitution 🧵 academic.oup.com/gbe/advance-...

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

Congratulations to co-first authors Kaoruko Nojiri & Koryu Kin, and thanks to all our collaborators!! ㊗️

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

These are the first handles for our "aging reconstitution into immortal Hydra" approach — putting aging traits back into a species that doesn't age, to test which factors are actually sufficient to drive it.

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

What it has instead is a distinct metabolic signature centred on mitochondrial energy production (OXPHOS) and nucleoside triphosphate (NTP) biosynthesis, implying a strategy for staying young

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

The paradox: the immortal species is the one missing canonical anti-aging genes. Klotho, NAMPT (NAD⁺ salvage) and DNA repair factors are found in H. oligactis and other aging animals, but not in H. vulgaris — lineage-specific losses.

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

evolutionary comparison: immortal H. vulgaris vs aging-inducible H. oligactis, plus other aging animals. The core pathways implicated in aging are conserved in Hydra — so the interesting part is where the two species differ.

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

We built a high-quality, chromosome-level genome of H. vulgaris strain AEP.JNIG, a lineage maintained in Japan. Its quality is comparable to existing references, which lets us dissect genomic diversity across laboratory strains.

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DBSB_Juntendo / Susaki-lab @susaki-lab.bsky.social · 27/08/2026

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