In this article, Riddell and colleagues identify that a novel human placental-specific PRKCZ isoform, aPKC-ζ III, promotes progenitor cytotrophoblast fusion during first-trimester development. Mechani...

The first trimester of pregnancy is a critical developmental period for the placenta. In humans, the maternal-facing exchange surface is formed by a single giant multinucleate syncytium: the syncytiot...