iiinova — where your digital self keeps evolving

Reposted by Patricia Donnellan, MPH 🇺🇦📎

Kevin Mitchell @wiringthebrain.bsky.social · 5h

Why optogenetics deserves the hype www.wiringthebrain.com/2013/09/why-... (a piece I wrote in 2013 explaining how it works and why modulating specific cell types is so key to understanding how neural circuits and systems work)

wiringthebrain.com

Why optogenetics deserves the hype

Optogenetics has come in for some stick lately, with a number of people criticising the hype that this technique generates in some quar...

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

Scientific American @sciam.bsky.social · 5h

BREAKING: The 2026 Nobel Prize in Physiology or Medicine is awarded to Karl Deisseroth, Georg Nagel and Peter Hegemann for their discovery of rhodopsin and optogenetics, the ability to control cells using light and genetics

scientificamerican.com

2026 Nobel Prize in Physiology or Medicine awarded to scientists behind optogenetics

Karl Deisseroth, George Nagel and Peter Hegemann developed optogenetics, which uses light and genetics to control individual cells

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 02/10/2026

A few months ago my mother almost died. She had acute signs of adrenal crisis, but doctors refused hydrocortisone because her labs were "normal." They had no idea the crisis was happening inside the cells, invisible to their tests. Once they relented, her BP rose and she stabilized. 👇 (1/3)

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 01/10/2026

The hashtag #NEISVoid stands for No End In Sight. But the end to your suffering is coming. I lived in that cellular shutdown for 28 years and I am 10 months free now. I won't stop until the medical system that kept you sick and suffering has to atone for its sins. #rs5522

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 01/10/2026

ME/CFS patients were prescribed GET and CBT on the belief they were just deconditioned and depressed. They said it made them worse. Medicine called them liars. The patients were right. Medicine was wrong. The patients were never the problem—the paradigm was. 👇 #NEISVoid (1/2) #MECFS #rs5522

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 30/09/2026

I spent 28 years with #MECFS and now 10 months without. Restorative sleep and reliable energy without punishing PEM has to be felt to be believed. Any theory of psychosomatic malingering is epic bullshit. #NEISVoid

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 30/09/2026

Why is mainstream medicine blind to what's happening inside the cells of #ME/CFS patients? They leave patients lacking a vital hormone needed for energy & fighting inflammation. Standard testing looks in the wrong place. It completely misses the internal roadblock that starves cells. 👇 #NEISVoid

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 28/09/2026

We were taught to see separate diseases, but separateness is the illusion we must unlearn. There is only one chronic disease: inflammation. It's driven by overactive mineralocorticoid receptors stealing the tissues' anti-inflammatory brake, cortisol in the cell—invisible on lab tests. #rs5522

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 28/09/2026

Does #LongCovid represent a lingering viral ghost? The evidence is slim. The virus doesn't need to stay in your body to keep you sick. It just acts as an initial sledgehammer that alters your glucocorticoid receptors, pushing an already strained #rs5522 system over the precipice.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 28/09/2026

The 20th-century framework assumed if a hormone is in the blood, it fuels your cell receptors. Labs measure total volume, but miss the heist where an overactive MR receptor steals cortisol before it can fuel cells. Your labs are normal. Your tissues are inflamed. Read about the breakthrough below. 👇

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 27/09/2026

Big Pharma was never going to investigate a generic drug that could prevent multiple conditions because they only make money when you are sick and desperate. Corporate greed is destroying our civilization and keeping you sick for profit. Demand action. #rs5522 Read the science below. 👇

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 27/09/2026

How did the genetic cause of ME/CFS stay hidden this long? One big reason: the assumption that lab values can ever tell you what is happening in the cell. The elevation of lab values over patient experience is one of the biggest scandals of modern medicine. #rs5522 #MECFS #LongCOVID #PwME #Spoonie

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 27/09/2026

If there is a fire and I tell you about it, you have a moral obligation to act, not tell me to let the entire city know myself. The suffering is too great. If you read about #rs5522, share often and loudly until someone listens. People are suffering.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 27/09/2026

They have #pwMe so gaslight into thinking there is no cure that when I say THERE IS A CURE, people think I must have never had the life stealing condition. But I suffered, And suffered. And then a 60 yr old drug made it stop. Turns out it had already worked in a clinical trial in 2021!

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 27/09/2026

"Abandoned dismissed and gaslighted" That's how @georgemonbiot.bsky.social descibed ME/CFS patients. That was my life for 28 yrs until I found the biophysical mechanism driving the condition. Invisible on lab tests, cortisol gets stolen at the receptor level. Treatment was cheap, generic and quick.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 26/09/2026

Every disease you worry about, every condition that someone you love has suffered from, likely was the downstream effect of overactive #rs5522 mineralocorticoid receptors that set in motion untold suffering. It’s all connected. Demand action. Read the science below. 👇

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 24/09/2026

This week marked World Alzheimer's Day, and while millions suffer and lose their memories, studies have linked MRAs with an 18% reduction in dementia risk. So why haven't you heard about exciting new clinical trials? Because there is no profit in a drug that has been generic for over 60 years.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 24/09/2026

Mainstream medicine completely forgot other hormones bind to the MR. Huge TriNetX database analysis of heart failure cohorts shows spironolactone use drops Alzheimer's risk by 18% and dementia by 9% over 3 years. It is a protective tissue shield crossing the BBB, not just a water pill. #rs5522

hcplive.com

In Heart Failure Patients, Spironolactone Linked to Reduced Risk of Dementia, Alzheimers Disease | HCPLive

A propensity score-matched analysis of data suggests use of spironolactone could reduce the 3-year risk of developing Alzheimer disease or dementia among patients with heart failure with reduced eject...

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 24/09/2026

It took me less time to find the biophysical mechanism driving #ME/CFS and #LongCovid than it has to get anyone to act on the research. Is it because we would have to admit that our existing tests failed patients and the drug that could grant recovery has been in every pharmacy for decades? #rs5522

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 21/09/2026

A vision for peace isn’t naive. War is an ideology sold to enrich those selling fear for power and weapons for profit. Humanity will break out of the delusion that violence is inevitable. Peace isn't passive; it’s an active fight against greed, and the organizing principle of a compassionate society

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

Elliot Kirschner @elliotkirschner.bsky.social · 19/09/2026

The problem of course is not the press. It is that Donald Trump should have been impeached and permanently banned from the White House after January 6.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 19/09/2026

#ME/CFS is not an unknowable mystery illness—at least it doesn't have to be. It is a direct consequence of mineralocorticoid receptor overactivity and subsequent glucocorticoid receptor starvation driven by the #rs5522 variant. #MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 18/09/2026

I highly recommend "The Woman Who Smashed Codes." I have massive respect for a woman who loves words, sees hidden patterns, and uses that sharp, independent reason to fight evil.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 18/09/2026

Every day I wake up and wonder if today will be the day someone else notices that what we have been taught to see as "obesity" is not just adipose tissue, but trapped inflammatory fluid densly locked in a GAG bound gel-like matrix. It doesn't erase the unearned social stigma, but it helps. #rs5522

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 17/09/2026

While the "Hundredth Monkey" effect may be literally debunked, I still hope for a critical threshold of collective awareness. We need a mass awakening to help #pwME see that static cortisol blood tests are actively hiding the chronic MR overactivity and systemic GR starvation driving their symptoms.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 17/09/2026

We are stuck in 20th-century organ models. 21st-century medicine belongs to receptor biophysics. Receptors don't have a fixed setting; how they respond to hormones depends entirely on the local cellular environment. Thinking a blood test can capture this receptor variation is dangerously outdated.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 17/09/2026

Turned on TV in Michigan and the ads against Abdul El-Sayed are laughably horrific. They imply he wants to let criminals run free or is buddy-buddy with 9/11 terrorists. Transparently ridiculous. The script is literally: fear, fear, foreign-sounding name, fear, be terrified. Embarrassing garbage.

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

Robert Reich @rbreich.bsky.social · 16/09/2026

Just a random reminder that it's a moral outrage we're the only industrialized country without paid family and medical leave.

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

Mr. Blabalino 🇳🇴🇺🇸💙 @blabalino.com · 15/09/2026

Octopus DNA is so complex, scientists still don't understand it. While all other animals on earth evolve through multiple generations, octopus DNA can change while they are alive. This started the talk about octopus "alien DNA". Scientific paper below the video.

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

Dr. Todd Arrington @btarrington.bsky.social · 14/09/2026

"We now know that there never can be a free humanity until woman is freed from ignorance, & we know, too, that woman can never call herself free until she is mistress of her own body." ~Margaret Sanger, 1918. Birth control advocate/nurse/author Sanger was born OTD in 1879. Image: LA Times/UCLA.

This black and white photo shows a woman, Margaret Sanger, wearing a white hat, white shirt, and dark coat.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 14/09/2026

“If more of us valued food and cheer and song above hoarded gold, it would be a merrier world.” ― J.R.R. Tolkien

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 14/09/2026

Why do some stay sick after an infection? Viral persistence? No. With #rs5522, baseline MR overactivity is there. The infection just kicks a system on the precipice into symptoms, turning a genetic trait into permanent GR starvation, capillary leaks, and tissue hypoxia long after the virus is gone.

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

darren32359.bsky.social @darren32359.bsky.social · 13/09/2026

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 10/09/2026

We have made historic strides in sequencing the human genome, but the legacy "one gene, one disease" paradigm has blinded us. 🧬A single genetic variant doesn’t always dictate a single disease box. One gene variant can alter how your cells react to other genes and the environment. #Genomics #rs5522

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 09/09/2026

Things I enjoy: improv, travel, books. 🎭✈️📚 Things I never expected to be on my bingo card of life: discovering that most modern chronic disease is a preventable, inflammation-driven process triggered by an overactive mineralocorticoid receptor (MR) invisible on existing tests.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 09/09/2026

Eleanor Roosevelt was dismissed as a mere token appointment on the 1946 UN Human Rights Commission. Male peers assumed she lacked depth, but she was elected chair and out-maneuvered them through grueling work. By 1948, her execution earned a standing ovation for the finalized Declaration.

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

Michael Warburton @michaelwarburton.bsky.social · 08/09/2026

One of the best acceptance speeches I've ever heard, given by FRED ROGERS upon receiving his Lifetime Achievement Award at the 1997 Emmy's. Beautiful stuff.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 08/09/2026

Are you suffering from unexplained fatigue, pain, and inflammation? What if your body is trapped in a physical nightmare because medicine is missing a hidden genetic driver? Millions are being told it’s in their heads and their labs are normal while their bodies collapse. Share & demand action.

beyondbloodtests.org

Beyond Blood Tests | The Truth About Chronic Disease

Discover the genetic driver behind chronic disease. Learn about the safe, generic drugs that can prevent and treat CFS, MS, Diabetes, Hypertension and more.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 06/09/2026

Can I just say, c'mon people—didn't there have to be something fundamentally wrong with the tests we were using when millions of people with #ME/CFS or #LongCovid were told they had "normal" labs? Seriously. You think millions of people just decided to fake debilitating and crushing fatigue?

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 06/09/2026

Once you realize that almost every major chronic disease is really just a raging bonfire of inflammation, the entire trillion-dollar circus suddenly clicks into focus. You stop seeing separate diseases, and you start seeing the downstream pattern of a massive corporate grift. #BioSky #MedSky

medium.com

The Trillion-Dollar Grift: How Pharma Chose Profit Over Prevention

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 06/09/2026

I’ve been completely ME/CFS free for 10 months after 28 years of suffering. Yet, in the most underfunded disease space in history, the medical establishment is still entirely blind. They waste time on downstream symptoms while totally ignoring upstream receptor biophysics and MR/GR signaling.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 06/09/2026

Occam’s razor forces a choice: are there hundreds of distinct disease mechanisms requiring separate specialists, or does one mechanism—chronic inflammation from hyperactive mineralocorticoid receptors—manifest in myriad ways depending on which organ bears the greatest burden?

beyondbloodtests.org

Beyond Blood Tests | The Truth About Chronic Disease

Discover the genetic driver behind chronic disease. Learn about the safe, generic drugs that can prevent and treat CFS, MS, Diabetes, Hypertension and more.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 05/09/2026

“Joy doesn't betray but sustains activism. And when you face a politics that aspires to make you fearful, alienated and isolated, joy is a fine act of insurrection.” ― Rebecca Solnit, Hope in the Dark: The Untold History of People Power

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 03/09/2026

We celebrate Dolly Parton and Gloria Steinem for art, activism, and lifting up others. They served with grace and grit. Some in government claim our stake in this country relies on reproduction, but our greatest citizens prove otherwise. Our lives are measured by our impact, not our fertility.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 03/09/2026

“In everyone's life, there is great need for an anam cara, a soul friend. In this love, you are understood as you are without mask or pretension... Love allows understanding to dawn, and understanding is precious. Where you are understood, you are at home." ― John O'Donohue🇮🇪✨🌱

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Reposted by Patricia Donnellan, MPH 🇺🇦📎

Jen Mercieca @jenmercieca.bsky.social · 03/09/2026

"You should write about take no-shit women like me. Girls need to know they can break the rules." ― Gloria Steinem, My Life on the Road

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Captain Mark Kelly @captmarkkelly.bsky.social · 02/09/2026

Before losing her life in 1986 aboard Space Shuttle Challenger, Christa McAuliffe was set to be the first teacher in space with plans to teach a lesson to kids around the world from orbit. Today is her birthday, and even now, her courage and dedication to education continues to inspire.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 02/09/2026

In ancient Hindu texts, transgender people were revered as possessing divine status, yet transgender people in India face exclusion from temples and other sacred spaces. An activist responded by creating a Kali temple where transgender people can worship, gather, and find community.

fetzer.org

A Transgender Woman's Spiritual Reclamation in India

Transgender activist Sowndharya Gopi built a Kali temple in Chennai, honoring and celebrating the spirituality of the transgender community.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 02/09/2026

Barbara McClintock proved genes move, defying rigid dogmas. Derided & dismissed by peers in 1951, she stopped publishing & worked in isolation. Decades later, molecular proof vindicated her, winning her the 1983 Nobel Prize. Paradigm shifts are often met with hostility by those who don't understand.

laskerfoundation.org

Barbara McClintock: A-“maizing” Insights about Jumping Genes - Lasker Foundation

SEPT. 25, 2020Read about the revolutionary genetic discoveries that challenged established concepts.

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Patricia Donnellan, MPH 🇺🇦📎 @stpaulsbay.bsky.social · 02/09/2026

“You must not lose faith in humanity. Humanity is like an ocean; if a few drops of the ocean are dirty, the ocean does not become dirty.” ― Mahatma Gandhi

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