iiinova — where your digital self keeps evolving

Steve Pittelli, MD @stevepittelli.bsky.social · 19/09/2026

Where have all the BG GWAS gone? Have we called it quits? 🧬🖥️🧪

Steve Pittelli, MD @stevepittelli.bsky.social · 10/09/2026

There are many ways to take a study like this but, generally speaking, It suggests that “small but significant” findings in the social sciences are not useful, whether it be horoscopes, behavioral genetics or anything else.

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Steve Pittelli, MD @stevepittelli.bsky.social · 03/08/2026

Barrage of Mark Sanford for Senate ads here in SC. Heh.

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Steve Pittelli, MD @stevepittelli.bsky.social · 18/07/2026

Granted, I’m just a watch the World Cup every 4 years guy, but this 3rd place game suggests teams play way too deliberately conservative. Whatever you say about France’s effort level, they are still a better team than most of the teams that kept it a 2 to 1 game (France scores as I write this).

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Steve Pittelli, MD @stevepittelli.bsky.social · 08/07/2026

pubmed.ncbi.nlm.nih.gov/37792698/ Genetics of vegetarianism: A genome-wide association study I was discussing this study with someone recently and couldn’t find a link, so I did a little AI search to find it and maybe it’s worth discussing AI in this context, and how it can reinforce ideology.

pubmed.ncbi.nlm.nih.gov

Genetics of vegetarianism: A genome-wide association study - PubMed

A substantial body of evidence points to the heritability of dietary preferences. While vegetarianism has been practiced for millennia in various societies, its practitioners remain a small minority o...

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Steve Pittelli, MD @stevepittelli.bsky.social · 26/06/2026

Quite annoyed by ESPN incorporating professional wrestling into their sports news. Nothing against it, but I just don’t think it should be included with regular sports, unless we are operating under the assumption that predetermined outcomes are okay in sports (sorry if you didn’t know, ha ha).

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Steve Pittelli, MD @stevepittelli.bsky.social · 23/06/2026

Suggestion (obviously from an American): instead of “extra time,” simply stop the clock during the game, so that the game always ends at the 90 minute mark.

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Steve Pittelli, MD @stevepittelli.bsky.social · 16/06/2026

These kinds of secret societies shape history and power in profound ways and are protected from discourse by accusations of conspiratorial thinking. There is a whole history of this country that sits behind the history we learn about in school and through the media.

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Steve Pittelli, MD @stevepittelli.bsky.social · 24/04/2026

They could have had him at 9. Panic trade.

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Steve Pittelli, MD @stevepittelli.bsky.social · 14/03/2026

I know behavioral genetics proponents try to disavow this kind of garbage, but this is exactly the problem with continuing to pump up what is essentially a null field. It unconsciously justifies cruelty, wars and genocide, among other problems. www.huffpost.com/entry/trump-...

huffpost.com

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Steve Pittelli, MD @stevepittelli.bsky.social · 25/12/2025

Wow! “Joshua Johnson is an American professional football quarterback for the Washington Commanders of the National Football League (NFL). Johnson has been a member of 14 different NFL teams, the most in league history. He also played in the United Football League (UFL) and XFL.”

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Steve Pittelli, MD @stevepittelli.bsky.social · 22/11/2025

I’m making a bit of a joke, but it’s worth discussing some broader issues, here. The first is that “we” in this sense, points to an ideology. I’ve taken a lot of ridicule from what would be considered leaders in the fields of behavioral genetics and my own field of psychiatry for questioning…. 1/

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Steve Pittelli, MD @stevepittelli.bsky.social · 18/11/2025

🧬 Let’s do a GWAS on zip code. Say, the first two digits are 70 (my choice). You will likely get some correlations if the sample is large enough. What percentage of the variance explained will you get for the SNPs for “70” zip code? Say it’s 10% even with your PCA’s. Is “70” zip code genetic? Now…

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Steve Pittelli, MD @stevepittelli.bsky.social · 23/09/2025

Nicest Lions regular season win I’ve seen in the 55 years I’ve watched them. #DetroitLions

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Steve Pittelli, MD @stevepittelli.bsky.social · 06/08/2025

It’s amazing how many articles I’ve read like this in the past quarter century. It’s malpractice to base clinical psychiatric decisions on genetic studies at this point. There is just nothing there. psychiatryonline.org/doi/10.1176/...

psychiatryonline.org

Psychiatry Online

PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.

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Steve Pittelli, MD @stevepittelli.bsky.social · 12/06/2025

Asked if any actors were in both Escspe from Alcatraz and Shawshank redemption:

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Steve Pittelli, MD @stevepittelli.bsky.social · 18/05/2025

One of the reasons I abhor the largely null field of behavioral genetics is this kind of reckless stupidity from someone well known in the field. BG is bad science with an inevitable and harmful endpoint. They haven’t found a thing in 65 years. Let it die.

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Steve Pittelli, MD @stevepittelli.bsky.social · 29/03/2025

NCAA, no one will die on the West Coast if you start games an hour earlier.

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Steve Pittelli, MD @stevepittelli.bsky.social · 08/02/2025

I originally wrote this as a preprint for a poster presentation at the ASHG conference last year. It was apparently removed from the server. It’s an easy read, I think, critiquing the field of behavioral genetics. open.substack.com/pub/unwashed...

open.substack.com

The Question That Must Be Asked: Is Behavioral Genetics a Null Field?

Steve Pittelli, M.D.

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Steve Pittelli, MD @stevepittelli.bsky.social · 03/02/2025

My review of “Understanding the Nature-Nurture Debate,” by Eric Turkheimer. Where do we go from behavioral genetics now that it has apparently reached a dead-end? Tried to make it an easy read for those not as familiar with this important topic. open.substack.com/pub/unwashed...

open.substack.com

A Review of "Understanding the Nature-Nurture Debate," by Eric Turkheimer

Gloomy Prospect or Exciting Opportunity?

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Steve Pittelli, MD @stevepittelli.bsky.social · 15/01/2025

“The European-only analysis identified 622 SNPs in 570 regions with a net change in the full meta-analysis of 65 (142 regions gained, 77 regions became non-significant).” This depression GWAS is a failed result and suggests that the correlations are spurious. 🧬🖥️ www.cell.com/cell/fulltex...

cell.com

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Trans-ancestry GWAS of major depression identifies 697 genetic variants and 308 genes, implicating neural and molecular mechanisms and drug repurposing opportunities.

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Steve Pittelli, MD @stevepittelli.bsky.social · 10/01/2025

This speculative push for gene editing, which has all the validity of astrology, is made by a leader in the largely null field of behavioral genetics. Astrology is mostly harmless, though. This is dangerous and invalid on many levels. www.nature.com/articles/s41...

nature.com

Heritable polygenic editing: the next frontier in genomic medicine? - Nature

We discuss the potential consequences and ethical concerns of polygenic genome editing of human embryos to alter specific variants associated with polygenic diseases, highlighting the possibility of r...

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Reposted by Steve Pittelli, MD

The All Gritt Podcast @all-gritt-podcast.bsky.social · 15/11/2024

If you can see this starter pack and you’re a Detroit lions fan, repost this so others can find it! And if you want to be added, comment below and I’ll get to you as quickly as I can! go.bsky.app/Dxdo7Qv

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Steve Pittelli, MD @stevepittelli.bsky.social · 16/11/2024

How does Alabama get away with playing Mercer, especially this late in the season?

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Steve Pittelli, MD @stevepittelli.bsky.social · 09/11/2024

To new followers, my not-so-hidden agenda is to tear down the premise of “behavioral genetics;” The idea that differences in personality, intelligence and the risk for mental disorders have a significant genetic basis. I contend in this preprint that this is not the case: 1/ osf.io/preprints/ps...

osf.io

OSF

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Steve Pittelli, MD @stevepittelli.bsky.social · 29/10/2024

My challenge of the entire premise of behavioral genetics in this “preprint,” below. On an unrelated note, will they find the treasure during the 12th season of The Curse of Oak Island? 🧬 osf.io/preprints/ps...

osf.io

OSF

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Steve Pittelli, MD @stevepittelli.bsky.social · 29/10/2024

Wherein I challenge the entire premise of Behavioral Genetics: osf.io/preprints/ps...

osf.io

OSF

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Steve Pittelli, MD @stevepittelli.bsky.social · 14/09/2024

Within family GWAS and pgs takes a hit. Behavioral genetics is the null field that no one can quit. www.pnas.org/doi/10.1073/...

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Steve Pittelli, MD @stevepittelli.bsky.social · 13/02/2024

🧬🖥️ Using that big Biobank for your sparkly new GWAS? Hey it’s the same one everyone else uses for their GWAS and the same one you used for your last GWAS. That comforting, familiar dataset is available to all, allowing us to design a study with foreknowledge of the data. Interesting.

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Steve Pittelli, MD @stevepittelli.bsky.social · 18/11/2023

How does Alabama get away with playing Tennessee Chattanooga this late in the year? They should be dinged in the rankings for that maneuver.

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Steve Pittelli, MD @stevepittelli.bsky.social · 30/10/2023

I posted a preprint for the poster I’m presenting at #ASHG2023 this week. It is entitled, “The Question That Must Be Asked: Is Behavioral Genetics a Null Field?” I like to call it my “Oak Island” piece. Happy to discuss it in DC or here in the blue skies. osf.io/preprints/ps...

osf.io

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Steve Pittelli, MD @stevepittelli.bsky.social · 28/10/2023

Red card and not looking good for All Blacks. Bummer. #RWC2023

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Steve Pittelli, MD @stevepittelli.bsky.social · 28/10/2023

Looking forward to #ASHG2023 (sort of), where I will have a poster entitled: “The Question That Must Be Asked: Is Behavioral Genetics a Null Field?

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Steve Pittelli, MD @stevepittelli.bsky.social · 23/10/2023

An offense based largely around the tush push might work.

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Steve Pittelli, MD @stevepittelli.bsky.social · 10/10/2023

Not into the Pat McCafeezation of ESPN.

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Steve Pittelli, MD @stevepittelli.bsky.social · 30/09/2023

Any Americans wondering why you got Peacock, you now have access to the Rugby World Cup, with the quarterfinals coming up soon. This is not your drunken biker’s rugby. Very high level. Catch Ireland, South Africa, New Zealand (with Haka as a bonus), or any of the games. Fun and fast. #RWC23

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