iiinova — where your digital self keeps evolving

Steven Julious @stevenjulious.bsky.social · 16/06/2026

The qualitative results of the MissionEB trial have just been published MissionEB is a trial that investigated the effect of mesenchymal stromal cell infusions of umbilical cord-derived mesenchymal stromal cells in children with recessive dystrophic epidermolysis bullosa doi.org/10.1186/s130...

doi.org

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Reposted by Steven Julious

Munya Dimairo @mdimairo.bsky.social · 08/05/2026

We are seeking key stakeholders in clinical trials research and related decision-making processes to contribute to guidance development on statistical analysis plans for adaptive and platform trials and on the disclosure of interim information in these trials. See details below 👇🏾👇🏾

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Steven Julious @stevenjulious.bsky.social · 05/05/2026

Just had a review published in Pilot and Feasibility Studies on sample size calculatons for pilot cluster trials. We identified 170 pilot cluster trials and found the median sample size per am was 4 clusters per arm rdcu.be/fg2Vf

rdcu.be

Sample size calculations for pilot cluster-randomised controlled trial: a review 2010–2020

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Steven Julious @stevenjulious.bsky.social · 27/04/2026

Have had a publication in The Lancet on considerations for improving for non-inferiority trials Discuss improvoing NI trials by: the setting of the NI margin; showing some advantage for the new treatment; checking the trial assumptions and setting the Type I error www.thelancet.com/journals/lan...

thelancet.com

Considerations for improving non-inferiority trials

Non-inferiority trials are a valuable type of clinical trial to evaluate new treatments that might have differing benefits. Such trials are increasingly used, but have methodological challenges in the...

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Reposted by Steven Julious

The BMJ @bmj.com · 17/12/2025

Doug Altman was an internationally renowned statistician who served as The BMJ’s chief statistical adviser. Read about life and work that made this statistician a "citation millionaire" #BMJChristmas www.bmj.com/content/391/...

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Reposted by Steven Julious

Richard Jacques @richardjacques.bsky.social · 16/10/2025

The first 12 months of our project evaluating same-day emergency care (SDEC) is nearly over. You can read about how the project is progressing on our website: sites.google.com/sheffield.ac... @fohsheffield.bsky.social @scharr-msg.bsky.social @arc-yharc.bsky.social #SDEC #NHS #NIHR

Reposted by Steven Julious

Beckie Simpson @beckiesimpson.bsky.social · 03/09/2025

Our PhD student is looking for children aged 5-16 with asthma in the UK to complete a survey to better understand inhaler use during the summer holidays among children and adolescents with asthma: shef.qualtrics.com/jfe/form/SV_... Please forward on. @stevenjulious.bsky.social

shef.qualtrics.com

Summer Holidays Inhaler Use

The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

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Reposted by Steven Julious

Rachel Phillips @rachpips.bsky.social · 28/05/2025

Next Thursday, June 5th at 1pm (BST) we host our 4th webinar in our adverse event special series. Rayan Taher & Jenny Yiend will present their work on developing a process for assessing the safety of a digital mental health intervention & gaining regulatory approval. Register here: lnkd.in/eaW3MQrB

forms.microsoft.com

Microsoft Forms

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Steven Julious @stevenjulious.bsky.social · 21/05/2025

A great talk at #SCT2025 by James Salsbury entitled Assurance methods for designing a survival trial with delayed treatment effects

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Steven Julious @stevenjulious.bsky.social · 21/05/2025

Attending an excellent talk by Nikki Totton at #SCT2025 entitled Using benefit risk methods to adjust the non-inferiority margin based on treatment benefits

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Reposted by Steven Julious

Marion Campbell @marionkcampbell.bsky.social · 19/05/2025

In clinical trials it is not only potential benefits that should be measured - it is crucially important that any potential #harms are also investigated 1/7 #MethodologyMonday #118

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Steven Julious @stevenjulious.bsky.social · 20/05/2025

Had a paper published with Kelly Grant on the analysis of recurrent events in clinical trials We recommend that the conditional frailty model be used for these data trials, including cluster randomised trials, to help explain changes in event risk over time, and assist clinical interpretation

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Steven Julious @stevenjulious.bsky.social · 05/02/2025

Today's date 5-2-25 Is a palindrome

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