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Reposted by Lucy Teece | Stats Enthusiast

RSS Celebrating Diversity @rssdiversity.bsky.social · 16/01/2026

📢 REMINDER! 📢 Less than two weeks to go for the "Statistics for Every Body: Inclusive Data Communication" on January 28, 2026! 🔗Get full event details and register here: bit.ly/Stats4Every1 #StatsSky #DataVis #RStats #InclusiveStats @royalstatsoc.bsky.social

bit.ly

Statistics for Every Body: Inclusive Data Communication for Audiences with Visual and Auditory Impai

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 19/12/2025

Looking for practical tips on how to make your Stats Comms more accessible? Join our Statistics for Every Body event 👇 🗓️ Wed 28 Jan 🕛 12:00 🌐 Teams link sent after registration 🔗 Bit.Ly/Stats4Every1 to register #StatsSky #DataScience

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 20/11/2025

A brilliant session! Informative and thought provoking and so essential for us to have these conversations given the current climate 🏳️‍🌈

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 14/10/2025

🎉 Happy International Day of Women in Statistics & Data Science #IDWSDS @rssdiversity.bsky.social are at the conference today covering some awesome Women and Books that Shift the View 👇 And @drnealsbooknook.bsky.social has curated an epic reading list of books by and for women! 😍 🔗 www.idwsds.org

Purple flyer for 4th annual International Day of Women in Statistics & Data Science Conference, advertising the session "Through her data lens: Women and books that shift the view" on 14 October 2025 at 12:15-12:30 BST with speakers Edith Milanzi, Penny Reynolds, Chiatra Nagaraja, Lucy Teece, and Bonita Natamba.

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Reposted by Lucy Teece | Stats Enthusiast

Helen Enever @helenenever.bsky.social · 10/10/2025

World Mental Health Day. Look after yourself ... and each other 🥰 #WorldMentalHealthDay #WMHD

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 24/09/2025

Happy #MathsWeekScot to all who celebrate! My feed has been joyously filled with imaginative activities & creative ways to make maths & stats more fun & accessible ☺️

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 05/09/2025

😍 Really enjoyed the session, thank you again to our speakers! Even if it did mean I got comments from a few men; one to tell me that he wouldn't have come if he knew it was going to be about women in stats (but were glad I "tricked" him) and to advise me to try to avoid being "too divisive" 🙄

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 03/09/2025

It me! Thank you @statsyss.bsky.social for the generous invite - and to the audience for laughing along with my mistakes and anecdotes ☺️

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 03/09/2025

Had to snap a *crafty* pic with #SignificanceMagazine competition finalist @sarahlotspeich.bsky.social and the fabulous crochet cardigan #Skye🦄 #RSSConf2025 #RSS2025Conf

Sarah wears a rainbow coloured daisy crochet granny square cardigan, I'm in a bright yellow full length dress showing off my purple and blue unicorn mascot

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 02/09/2025

Got ideas for future sessions for @rssdiversity.bsky.social - join us 👇 Or drop me a message - I'd love to hear from you 🙏

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 01/09/2025

🎶 I'm on my way Ah-hah (Ah-hah), Ah-hah (Ah-hah) 🎶 #RSS2025Conf

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 26/08/2025

🙋‍♀️ Anyone else started making plans for the royalstatsoc.bsky.social conference next week 😉 #RSSConf2025

Weekly calendar for 1st to 5th September showing which RSS conference sessions I plan to attend, some are highlighted to show which I will be chairing / supporting / speaking at

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/04/2025

🐥 I found the chick and got a free coffee ☕ 🔎 Now to hunt for 40 easter egg letters! Anyone fancy helping to solve some 10-letter anagrams later?! #EasterGames #EasterTreats

Mw holding a yellow fluffy chick toy with yellow glasses up to my face

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 05/04/2025

🏃‍♀️ 540 runners joggers and walkers today ☀️ Thank you for having me as RD, so much fun! #ParkRun

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 03/04/2025

Fantastic resource - Thanks for sharing! May be of interest for the @rssdiversity.bsky.social members?! 👀

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 03/04/2025

📣It's official - I'm Run Director at #ParkRun this week 😁 🏃🚶🐕

Email from Rushcliffe Parkrun tanking volunteers and reminding them that this weeks Run Director will be me (Lucy Teece)!

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 19/03/2025

Silly question - do you have multicoloured thread or are you changing colours? It's beautiful 🤩

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Reposted by Lucy Teece | Stats Enthusiast

Royal Statistical Society @royalstatsoc.bsky.social · 26/02/2025

Welcome to the Royal Statistical Society Bluesky and a hello to our new followers 👋 For the latest stats and data insights here is our starter pack of RSS fellows and groups ⤵️

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 27/02/2025

Yay! What ones have you got lined up?! I need a stats / popsci restock 📕📙📒📗📘

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 27/02/2025

Always happy to boost posts and sessions about #WomenInData #WomenInStats and #WomenInSTEM But it feels particularly important this year! 👇 This looks like a fantastic event Please share more with me (what tags and packs should I be following?) 🙏

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 26/02/2025

A great way to find out about upcoming #Stats events is to follow the @royalstatsoc.bsky.social starter pack 👇 go.bsky.app/HbNRCFp #StatSky #Data

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 25/02/2025

😄 When you find an analogy that perfectly fits, and you know you're going to use it to explain what you do... "Consider a phase I-II design to be like a Labradoodle" 🐕🐩

2.2 Elements of Phase I-II Designs

One may consider a phase I-II design to be like a Labradoodle, which is ob-tained by cross-breeding a Labrador Retriever with a Poodle. Labradoodles enjoy the desirable quality of heterosis, or hybrid vigor, since they have greater genetic diversity and hence better overall health than either of their parents. Hybrid clinical trial designs, if carefully constructed, enjoy similar advantages over the simpler designs that motivated them. The analogy is not strict, how-ever, since both Labradors and Poodles both are fine canine breeds, whereas the most commonly used phase I or phase II clinical trial designs suffer from logical and ethical flaws, as we demonstrated in Chapter 1

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 24/02/2025

How would you communicate that being a "logical robot" 🤖 is better for the "greater good", and that the emotional response to deviate from the plans is not a sensible thing to do?

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 24/02/2025

It's challenging to communicate how to differentiate between decisions made in medical practice compared to scientific experiments #Trials follow rational, ethical processes to maximise benefit to patients Hearing "real" patient stories can make it difficult to not let emotion impact decisions

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 21/02/2025

Sandi and Ada, a great Friday night in Cambridge

Sandi at a podium presenting a picture of Ada Lovelace

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Reposted by Lucy Teece | Stats Enthusiast

Dr Katherine Whyte @kateywhyte.bsky.social · 17/02/2025

Don't miss this unique opportunity to be one of the next RSS William Guy Lecturers- highly recommend the experience! 🤗

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 18/02/2025

🚫 Traditional Phase I expansion cohorts have many problems and poorly serve patients 👎 Fail to adequately protect patient safety 👎 No true experimental design or stopping rules 👎 Poor job optimising dose or schedule 👎 Numerous logical problems 💡Solution: Phase I-II sequentially adaptive designs

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 17/02/2025

Summary: 🛑 The 3+3 design is inferior ☣️ Phase I designs focus on toxicity 📈 Ignoring efficacy information could be unethical if efficacy-toxicity relationship assumptions incorrect

Extract from trials book:

These examples may be summarized by the following key points for settings where both Efficacy and Toxicity may be observed quickly enough to make adaptive decisions.

1. 3+3 algorithms do a poor job of choosing a MTD.

2. Conventional phase I sample sizes are far too small.

3. It often does not make sense to base dose-finding on Toxicity alone.

4. It does not make sense to design a phase II trial based on Efficacy alone, since safety is an important concern in any clinical trial and the trial must be stopped if excessive Toxicity is observed.

5. The inclusion of a rule based on Efficacy to stop for futility in phase I-II underscores the important point that, at the completion of a phase I-II trial, there is no reason to conduct a conventional phase II trial since it already has been done.

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 17/02/2025

Trying to convince your team to plan slightly larger phase I-II trial (over phase I alone)... "A phase I trial is not an obstacle to overcome quickly. Rather, if possible it should be a Phase I-II trial... Regarded as an experiment to obtain precious information to optimise a new agent." #StatSky

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 11/02/2025

Happy International Women & Girls in Science day 👩🏻‍🔬🧑🏼‍💻👩🏾‍🔬 Always a great opportunity to get online and learn more about some fantastic historical innovators #WomenInScoence #WomenInSTEM @rssdiversity.bsky.social

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 05/02/2025

📖 Starting "Bayesian Design for Phase I-II Clinical Trials" today 🤓 "These first two chapters are written so that they can be understood by nonstatisticians seeking enlightenment or entertainment" 💡 Perfect fit for my February mornings 🌞 doi.org/10.1201/b21600 #StatSky #OncSky #Stats #Bayes

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/01/2025

Developments and alternatives include: 🟰 𝗘𝗾𝘂𝗶𝘃𝗮𝗹𝗲𝗻𝘁 𝗧𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝗦𝗰𝗼𝗿𝗲 (𝗘𝗧𝗦): which uses modified isotonic regression 🕵️‍♀️ 𝗤𝘂𝗮𝘀𝗶-𝗖𝗥𝗠: which incorporates toxicity scores using a Bayesian CRM framework

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/01/2025

🧩A composite toxicity score was introduced: 𝗧𝗼𝘁𝗮𝗹 𝗧𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝗕𝘂𝗿𝗱𝗲𝗻 (𝗧𝗧𝗕) ⚖️ Severity weights (representing patient burden) defined for each toxicity, gives toxicity score ☠️ Grade 5 (deaths) not given weights 📈 Models continuous toxicity score as a function of dose

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/01/2025

The model based CRM design has been extended to model ordinal outcomes: ✅ Proportional Odds model ✅ Continuation Ratio model ⚠️ Patients toxicity 🟰 highest grade experienced 🔎 Dose-finding model used to estimate probability of toxic response at each toxicity grade

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/01/2025

The 𝗔𝗰𝗰𝗲𝗹𝗲𝗿𝗮𝘁𝗲𝗱 𝗧𝗶𝘁𝗿𝗮𝘁𝗶𝗼𝗻 𝗗𝗲𝘀𝗶𝗴𝗻 was introduced to account for the natural ordering of toxicities Uses an algorithmic framework 🤖 Now two grade-2 toxicities in a cohort (2️⃣+2️⃣), results in same decision as a single grade-3 (3️⃣+0️⃣)

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/01/2025

✂️ Dichotomising this ordinal grading into a binary safety endpoint... ❌ treats non-DLT toxicities as irrelevant ❌ignores harmful combinations of low-grade toxicities

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/01/2025

💭 Recall the CTCAE guidelines for defining toxicities across organ classes, use an ordinal (0-5) grading: 🔗 ctep.cancer.gov/protocoldeve... bsky.app/profile/stat...

ctep.cancer.gov

Protocol Development | CTEP

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 16/01/2025

🧵More from 𝗖𝗵𝗮𝗽𝘁𝗲𝗿 𝟯 - 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗣𝗵𝗮𝘀𝗲 𝗜 𝘁𝗿𝗶𝗮𝗹𝘀 ❓What happens when we move away from binary safety endpoints: ⚠️Spoiler alert - improved performance! 👍 #OncSky #StatSky

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 08/01/2025

It's glorious isn't it! I don't know whether to build a snowman or make a snow angel ❄️

Snowy landscape with frozen lake and clear blue sky

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 08/01/2025

🤯There's an R for Data Science BOOK CLUB! And videos to watch as you work through the FREE book😁 Stats communities are absolutely smashing it!

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Lucy Teece | Stats Enthusiast @stateecetics.bsky.social · 08/01/2025

⏰ Time-To-Toxicity-Event information can be incorporated using the 𝗧𝗜𝗧𝗘-𝗖𝗥𝗠 𝗱𝗲𝘀𝗶𝗴𝗻 This is useful when late-onset or cumulative toxicities are present 💊📈

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