During the 1980s and 1990s, a dispersed Euro-American counterculture reactivated the psychedelic project through the languages of shamanism, entheogen, Gaia…

cover photo by Morgan Russell We were working on our first Mondo 2000 issue. It was going to be the cyberpunk theme issue and we'd gotten interviews with

Yes, Deadheads came for the music, but also for the possibility of a life outside the bounds of straight society; something vaguely criminal and very American noir.

Both expertise and the ability to release one’s focus can help people enter a state of effortless attention

YouTube video by Rejected Religion

What To Fear from AI Agents and How to Reclaim Our Human Agency

The long read: Scientists are battling over whether supposedly simple organisms should be considered ‘intelligent’. The outcome could reshape our understanding of the natural world – and our own place...

Language, Imagination, and the Occult Power of Story

The bacteriophage ΦX174 was the first genome to be sequenced and the first to be chemically synthesised. Here we present a complete map of the consequences of changing every nucleotide in the ΦX174 genome and every amino acid in the proteome. In total, half of nucleotide and >60% of amino acid changes impair fitness. However, this varies substantially across proteins and non-coding regions. Surprisingly, the most important mechanistic cause of reduced fitness is disruption of protein interaction interfaces, accounting for nearly half of detrimental protein variants. A further one quarter of damaging variants disrupt protein cores but one in four lack a mechanistic explanation. Mutational effects are only moderately-well predicted by state-of-the-art artificial intelligence models, but, combined with structural modelling, provide mechanistic hypotheses and insights into the DNA replication machinery. This complete mutagenesis of a biological system quantifies the limits of our current understanding of, and ability to predict, molecular biology. ### Competing Interest Statement The authors have declared no competing interest.

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The long history of scribes being replaced by machines, and what cannot be replaced by LLM imitation in current writing.

In this exclusive interview, Andrei Eugen Drăguț speaks with physicist and complexity scientist James B. Glattfelder—from the hidden networks of global corporate control to the radical possibility tha...