Smoljaguar
@Smoljaguar.spacey.space.ap.brid.gy
5 followers 0 following 596 posts
fan of all things aerospace, also trying to learn about ai, low level software, hardware 🌉 bridged from ⁂ spacey.space/@Smoljaguar, follow @ap.brid.gy to interact
fan of all things aerospace, also trying to learn about ai, low level software, hardware 🌉 bridged from ⁂ spacey.space/@Smoljaguar, follow @ap.brid.gy to interact
![In 2009, former F1 racing champion John Surtees drove a Ginetta G50 EV electric sports car prototype from England to France, using the service tunnel, as part of a charity event. He was required to keep to the 50 km/h (30 mph) speed limit.[232] To celebrate the 2014 Tour de France's transfer from its opening stages in Britain to France in July of that year, Chris Froome of Team Sky rode a bicycle through the service tunnel, becoming the first solo rider to do so.[233][234] The crossing took under an hour, reaching speeds of 65 km/h (40 mph)—faster than most cross-channel ferries.[235]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreih4hhcgduhv5v5jrf4dd6sjjmextzh5u27vwxu5fkqf4z26wtvt6m)
![otropin, MTII, Ac-Nle-c[Asp, HisDPhe, Arg, Trp, Lys]-NH,
was conformationally restrained by a lactam bridge to pro-
vide a cyclic structure of increased lipophilicity (Fig. 1). The
smaller molecule is just as active as the larger MTL; it is
cheaper to synthesize and might gain access more readily
into the body. Based upon these and other considerations, a
sterile preparation was provided for injection to determine its
tanning potential.
One mistake in my deliberations was made, however. MTI
had previously been administered at a dose as high as 10 mg
without physiological consequences (other than tanning). I
forgot, however, that MTII was only about half the molecular
weight of MTI (Fig. 1). Therefore, when I took an equivalent
(10 mg) dose of MTII, I inadvertently received about twice
the number of molecules of the peptide. Unlike MTI, how-
ever, MTII caused a rather immediate, unexpected response:
nausea and, to my great surprise, an erection (no figure pro-
vided). While I lay in bed with an emesis pan close by, I had
an unrelenting erection (about 8 h duration) which could not
be subdued even with a cold pack. When my wife came upon
the scene, she proclaimed that I “must be crazy.” In response,
I raised my arm feebly into the air and answered, “I think we
may become rich.”](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreiebg673f2ejyuvhnvvibkg3i2vp4ojr26s35cb5jaenc3ib2aoe3i)
![Around 1984, in collaboration with Victor Hruby (Uni-
versity of Arizona Chemistry Department) and his students
(e.g., Tomi K. Sawyer), we synthesized and biologically char-
acterized some superpotent melanotropic peptides [9]. One of
these [Nle*, DPhe’]-substituted MCs, referred to as Melano-
tan I (MTT), was licensed for commercialization as a tanning
agent (Fig. 1). This MC is well on its way toward devel-
opment for use as a potential “therapeutic tan,” a “tan from
inside-out,” with minimal need for prolonged sun exposure
[4].
During the development of MTI, I served as a proverbial
“human pincushion” (a k.a., guinea pig), that is, I tested the
efficacy of the peptide to produce a tan on myself. Therein
lies a very interesting story. Our group of University inves-
tigators (Hadley, Hruby and his student Fahad Al-Obeidi)
prepared and characterized some fragment [Nle*, DPhe’]-
substituted MC analogs that proved to be as potent as MTI,
even though structurally only half the size (seven amino
acids) of the parent analog [1,2]. In addition, the melan-](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreiezsdvgt7seukjbhj54lawzkpzh53mgf7nd5q4hqwtzgftjh7lvaq)
![3 History
A proof that it is possible to divide by two was presented by Bernstein in his Inaugural Dissertation of 1901, which appeared in Mathematische Annallen in 1905 [2]; Bernstein also indicated how to extend his results to division by any finite n, but we are not aware of anyone other than Bernstein himself who ever claimed to understand this argument. In 1922 Sierpin ́ski [8] published a simpler proof of division by two, and he worked hard to extend his method to division by three, but never succeeded.
In 1926 Lindenbaum and Tarski announced, in an infamous paper [5] that contained statements (without proof) of 144 theorems of set theory, that Lindenbaum had found a proof of division by three. Their failure to give any hint of a proof must have frustrated Sierpin ́ski, for it appears that twenty years later he still did not know how to divide by three (cf. [9]). Finally, in 1949, in a paper ‘dedicated to Professor Waclaw Sierpin ́ski in celebration of his forty years as teacher and scholar’, Tarski [10] published a proof. In this paper, Tarski explained that unfortunately he couldn’t remember how Lindenbaum’s proof had gone, except that it involved an argument like the one Sierpin ́ski had used in dividing by two, and another lemma, due to Tarski, which we will describe below. Instead of Lindenbaum’s proof, he gave another.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreibfn2pdvnrtbdawjam32wntnilqiehxpn6niwxtmurkp3dydetq5u)
![In 1925 Werner Heisenberg was working in Göttingen on the problem of calculating the spectral lines of hydrogen. By May 1925 he began trying to describe atomic systems by observables only. On June 7, after weeks of failing to alleviate his hay fever with aspirin and cocaine,[3] Heisenberg left for the pollen-free North Sea island of Heligoland. While there, in between climbing and memorizing poems from Goethe's West-östlicher Diwan, he continued to ponder the spectral issue and eventually realised that adopting non-commuting observables might solve the problem. He later wrote:](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreicymrymrkrtronxege2n2loix3jo37hhtxvje53pnx5s5lq4kq42i)
![Opposite sides of a modern die traditionally add up to seven, requiring the one (1), two (2), and three (3) faces to share a vertex.[23] The faces of a die may be placed clockwise or counterclockwise about this vertex. If the one (1), two (2), and three (3) faces run counterclockwise, the die is called "right-handed". If those faces run clockwise, the die is called "left-handed". Western dice are normally right-handed, and Chinese dice are normally left-handed.[24]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreibbjudfmuhyt3kpuivukdmqlbhi23yfgmohfzkxt2x2kcd4lwzwiu)
![At the 1910 meeting, which originally defined the curie, it was proposed to make it equivalent to 10 nanograms of radium (a practical amount). But Marie Curie, after initially accepting this, changed her mind and insisted on one gram of radium. According to Bertram Boltwood, Marie Curie thought that "the use of the name 'curie' for so infinitesimally small [a] quantity of anything was altogether inappropriate".[2]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreibaxkra2ncm6fx6h6rfij3vvtzvrkok6te5i262pkstbl22quw4lm)
![Smear campaign
In the late 19th century, the newly consolidated refined white sugar industry, which did not have full control over brown sugar production, mounted a smear campaign against brown sugar, reproducing microscopic photographs of harmless but repulsive-looking microbes living in brown sugar. The effort was so successful that by 1900, a best-selling cookbook warned that brown sugar was of inferior quality and was susceptible to infestation by "a minute insect".[12] This campaign of disinformation was also felt in other sectors using raw or brown sugar such as brewing;
Raw sugars are all more or less liable to be contaminated with decomposing nitrogenous matters, fermentative germs, and other living organisms, both animal and vegetable....For this reason, raw sugars must always be considered dangerous brewing materials.
— E. R. Southby. A Systematic Handbook of Practical Brewing, 1885[13]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreifklbvkvh4buqsyuqdwckzllm5dg3bwr6j2fs4lpl7bz54uett5ry)
![the moon landing was staged?
[exploded saturn v photo]
Yeah thats how all orbital rockets fucking work dude](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreigiefhjkj4dkum3jcjbuxrlkwlg4pimusg53jydghifk36ih7bsrq)
![Theory of constructed emotion
Main article: Theory of constructed emotion
Barrett developed her current theory of constructed emotion originally during her graduate training.
According to Barrett, emotions are "not universal, but vary from culture to culture" (see Emotions and culture). She says that emotions "are not triggered; you create them. They emerge as a combination of the physical properties of your body, a flexible brain that wires itself to whatever environment it develops in, and your culture and upbringing, which provide that environment.".[18] Barrett also claims that "Smiling was an invention of the Middle Ages" and that smiling "became popular only in the eighteenth century as dentistry became more accessible and affordable".[19]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:twpq6p6npczmkd7uqegw2ee7/bafkreihowafrlcsmv26clb4fu6tv5r7c2hc6nzv3bh64ifb6cbyos4bc2u)