New paper on bioRxiv by YounJu So in our lab! She shows that while SMARCD paralogs compensate for each other during neurodevelopment, each still drives distinct gene expression programs, explaining selective vulnerability of these SWI/SNF subunits in brain disorders.
www.biorxiv.org/content/10.6...
biorxiv.org
Redundancy masks functional specificity of SMARCD paralogs in neurodevelopment
The SWI/SNF complex is an essential chromatin remodeler that regulates DNA accessibility during brain development. Through combinatorial assembly of subunits encoded by paralogous genes, SWI/SNF compl...