“Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity,” is now available at Cell Reports. MCU-KO blocks EMT & reduces metastasis in PDAC, reversed by Snail. @pitarresilab.bsky.social #sciencesky
www.cell.com/cell-reports...
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Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity
Weissenrieder et al. show that mitochondrial Ca2+ uniporter (MCU) deletion reduces
growth and metastasis of murine KPCY cells by reducing cell-autologous induction of
epithelial-to-mesenchymal transit...