🧬 A new report in Science Advances highlights how nonstop-mutations can alter translation initiation
Point mutations can affect all levels of gene expression, leading to #dysregulation and #cancer. Pal et al., Sci. Adv.
Read the full paper here: www.science.org/doi/full/10....
#siPOOLs #raPOOLs
science.org
Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation
Extending a protein at its end affects its stability, but also its translation efficiency and even selection of its start.