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Silas Kieser

@silask.bsky.social

Microbiome researcher, co-leader of a family of soon five, Developer of metagenome-atlas. silask.github.io

Silas Kieser @silask.bsky.social · 29/08/2025

We found many cases where only one subspecies associates with disease while sibling-subspecies don't. Sometimes no association is detected at species level because opposing subspecies associations cancel each other out.

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Silas Kieser @silask.bsky.social · 29/08/2025

Why it matters: Subspecies explain disease associations invisible at the species level. For example, in colorectal cancer, subspecies-based ML models consistently outperformed species-level ones.

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Silas Kieser @silask.bsky.social · 29/08/2025

We built HuMSub: the most comprehensive catalog of human gut microbiota subspecies (5,361 OSUs across 977 species). We found that 1/3 of species in the human gut have subspecies, most of which we knew nothing about.

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Silas Kieser @silask.bsky.social · 29/08/2025

New paper out: Subspecies of the human gut microbiota carry implicit information for in-depth microbiome research.

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Silas Kieser @silask.bsky.social · 20/05/2025

What do you think about our latest pre-print? 1/3 of human microbioal species have, mostly neglected, subspecies. Human gut microbiota subspecies carry implicit information for in-depth microbiome research doi.org/10.1101/2025...

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