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sigellab.bsky.social

@sigellab.bsky.social

Student-run account of the SigelLab. We love RNA, smFRET and NMR! In our lab, we determine structures and study dynamics of "active" RNAs. These active RNAs perform a function, e.g. self-cleavage or influencing gene expression.

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sigellab.bsky.social @sigellab.bsky.social · 05/06/2025

There's a joint spotlight collection on Bioinorganic Chemistry between Chemical Science and Dalton Transactions - and our paper on elucidating the structure of G4 quadruplexes (pubs.rsc.org/doi/D5SC01416F) has been selected! Check out the entire collection here: rsc.li/bioinorganic...

pubs.rsc.org

Spotlight Collection: Bioinorganic Chemistry Home

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sigellab.bsky.social @sigellab.bsky.social · 15/04/2025

Congratulations to Matteo Lisibach for winning the Semesterpreis of the University of Zurich for his outstanding master thesis entitled "Toward multiple coordinates: Resolving the intrinsic heterogeneity of a group II intron folding and splicing process". Very well done Matteo!

A folded RNA molecule in the confocal volume of a microscope and a graph showing excitations in the Cy3 and Cy5 channel. Expanding the single-molecule FRET toolkit to tackle complex macromolecular dynamics.

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sigellab.bsky.social @sigellab.bsky.social · 07/04/2025

Do you want to assign solution structures of G-quadruplexes using NMR? Maybe this new approach we just published works for you. Congrats to Zhenghui and Carla for this amazing work! doi.org/10.1039/D5SC01416F

doi.org

Elucidating the solution structure of the monomolecular BCL2 RNA G-quadruplex: a new robust NMR assignment approach

5′ untranslated regions (UTRs) of mRNA commonly feature G-quadruplexes (G4s), crucial for translational regulation and promising as drug targets to modulate gene expression. While NMR spectroscopy is ...

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sigellab.bsky.social @sigellab.bsky.social · 13/03/2025

And this is why we do RNA research. Credit: The incredible xkcd. xkcd.com/3056/

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sigellab.bsky.social @sigellab.bsky.social · 26/02/2025

Our collaborative work titled "G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs" was selected for the Inorganic Chemistry Frontiers Outstanding Papers Award! Thanks to everyone who has participated in this outstanding work!

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sigellab.bsky.social @sigellab.bsky.social · 25/02/2025

Hello bluesky! The SigelLab is now also here, we are looking forward to good science, fascinating stories and good discussions! This account is - as was our X/Twitter account - managed by Ph.D. students or PostDocs in our lab, not Prof. Roland Sigel himself.

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