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Sander Granneman

@sgrannem.bsky.social

Professor in RNA Biochemistry at the University of Edinburgh

Sander Granneman @sgrannem.bsky.social · 10/07/2026

ABA-AA: A simple, reversible, and non-toxic anchor-away system for effective nuclear protein depletion: Cell Reports Methods www.cell.com/cell-reports...

cell.com

ABA-AA: A simple, reversible, and non-toxic anchor-away system for effective nuclear protein depletion

Esteban-Serna et al. describe an anchor-away system that uses the plant hormone abscisic acid (ABA) to rapidly deplete proteins from the nucleus in budding yeast. Unlike existing approaches, the syste...

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Sander Granneman @sgrannem.bsky.social · 07/03/2026

www.biorxiv.org/content/10.6... A very challenging project spearheaded by my former PhD student Mehak. She setup all the methods used in this paper in my lab and went to Ohio to help setup the mouse work. So many challenges but hugely rewarding that we got some exciting results!

biorxiv.org

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Sander Granneman @sgrannem.bsky.social · 30/11/2025

www.biorxiv.org/content/10.1... A method for rapidly and fully reversibly depleting proteins from the nucleus. Ideal for studying transcription dynamics!

biorxiv.org

A simple, reversible and non-toxic anchor-away system for effective nuclear depletion of proteins

The anchor-away (AA) technique enables rapid depletion of nuclear proteins by tethering them to cytoplasmic anchors through rapamycin-induced heterodimerisation. Albeit powerful, in Saccharomyces cere...

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