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Seth Cheetham

@sethcheetham.bsky.social

1.1K followers 178 following 51 posts

mRNA drug discovery | Deputy-Director BASE mRNA Facility | Associate Professor at the University of Queensland.

Posts Replies Media

Seth Cheetham @sethcheetham.bsky.social · 16/05/2025

Today, a huge milestone for personalised #mRNA therapeutics for inherited disease! A baby with an ultra-rare mitochondrial metabolic disease was treated at UPenn with an mRNA-encoded gene-corrector. The mRNA was made to treat a single individual in just 7 months! www.nejm.org/doi/full/10....

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Seth Cheetham @sethcheetham.bsky.social · 02/04/2025

The technology is programmable and works with other targeting arms including anti-PSMA (highly expressed on prostate cancer cells) bispecifics. 6/

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Seth Cheetham @sethcheetham.bsky.social · 02/04/2025

Bispecifics can be used by combining with the mRNA-LNP (pre-mixing) or the bispecific can be administered first (pre-targeting). 5/

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Seth Cheetham @sethcheetham.bsky.social · 02/04/2025

As proof of concept we used anti-EGFR bispecifics to deliver mRNA to mouse breast cancer xenografts. The mRNA-payload (luciferase) is very efficiently delivered in vivo. 4/

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Seth Cheetham @sethcheetham.bsky.social · 02/04/2025

To overcome this obstacle we developed bispecific antibodies that bind to PEG on the surface of LNPs and to cell-surface markers. 3/

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Seth Cheetham @sethcheetham.bsky.social · 02/04/2025

Getting a high dose of mRNA to target tissues is one of the toughest problems for broad use of mRNA-LNP therapies. When administered systemically mRNA-LNPs go the liver with little delivery to other tissues. 2/

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Seth Cheetham @sethcheetham.bsky.social · 20/03/2025

Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc @laura-leighton.bsky.social found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics. www.biorxiv.org/content/10.1...

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Seth Cheetham @sethcheetham.bsky.social · 02/03/2025

Not the best weather forecast for Brisbane 😬

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Seth Cheetham @sethcheetham.bsky.social · 26/02/2025

Preach!

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Seth Cheetham @sethcheetham.bsky.social · 31/01/2025

Interested in undertaking a PhD in the transformative field #mRNA cancer vaccines? I have an earmarked #PhD scholarship available for an outstanding domestic student to join our team at UQ and @basemrna.bsky.social. If this sounds like you, get in touch. study.uq.edu.au/study-option...

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Seth Cheetham @sethcheetham.bsky.social · 09/01/2025

Out of office

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Seth Cheetham @sethcheetham.bsky.social · 06/12/2024

How I imagine our lab animals talk to each other.

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Seth Cheetham @sethcheetham.bsky.social · 18/11/2024

The greatest challenge for #mRNA-LNP therapies is targeting non-liver tissues. To overcome this, we developed customisable bispecific antibodies to tether mRNA-LNPs to cell-surface proteins, achieving efficient and selective mRNA delivery in vivo. Preprint 👇 t.co/0nJj8eVsqC

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