iiinova — where your digital self keeps evolving

Seth Cohen @sethalosporin.bsky.social · 22/12/2025

Interested in thoughts on any of these trials as well as suggestions for other literature to include. @uwidfellowship.bsky.social @pergamic.bsky.social @rupalij.bsky.social

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

Want the full reading list? See “Essential Publications in Infectious Diseases 2025” link below, with more details on essential literature from this year: pdf: app.box.com/s/ny7m9d0pdi... Ppt on request Thanks for reading and for everything you do.

app.box.com

Important ID publications 2025 Cohen.pdf | Powered by Box

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

8️⃣ Big Picture Takeaways 📌 Guidelines often rest on limited evidence 📌 Treatment durations keep shrinking—even for TB 📌 PO often >> IV. Safe and patient centered. 📌 RSV prevention is a true breakthrough 📌 Despite setbacks, this is still an exciting time to be in ID 👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

7️⃣ Vaccines: A Standout Year RSV vaccines: ~80–90% reduction in RSV hospitalizations in adults ≥60 mRNA flu vaccines: superior efficacy vs standard flu shots, with more reactogenicity Emerging data suggest mRNA vaccines may synergize with cancer immunotherapy Woot woot! 👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

6️⃣ COVID Therapeutics: Reappraisal Large real-world data suggest Paxlovid offers little benefit in highly vaccinated older adults. Its role in 2025 is increasingly narrow and should be framed honestly. 👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

5️⃣ Antimicrobials: Find the niche Cefiderocol: noninferior, not superior; reserve for salvage Olorofim: bright spot in mold infections. Rare mold trials are hard! Dalbavancin: viable consolidation therapy after S. aureus bacteremia clearance Gepotidacin is here! 👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

4️⃣ Mpox: A Hard Lesson in Evidence Randomized trials now show no clinical benefit of tecovirimat for mpox. Animal models and uncontrolled observational data may have misled us—an important cautionary tale for outbreak therapeutics. 👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

3️⃣ STIs: Paradigm Shifts Two practice-changing NEJM trials: Male partner treatment for bacterial vaginosis cut recurrence nearly in half Twice-yearly lenacapavir for HIV PrEP showed ~90% protection Implementation, cost, and access will determine real-world impact. 👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

2️⃣ Vector Control: Entomology ≠ Outcomes Three trials, three lessons: Ivermectin MDA ↓ malaria incidence Permethrin baby wraps ↓ infant malaria by 66% Indoor residual spraying dramatically ↓ mosquitoes but not infections Bottom line: endpoints are key 👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

1️⃣ Guidelines: Shorter, Oral, Individualized 2025 continues the trend toward less is more: CAP: shorter courses (3–5 days) if stable TB: 4-month regimens now endorsed for select patients cUTI: oral step-down even with bacteremia is appropriate Individualize guidance!👇

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Seth Cohen @sethalosporin.bsky.social · 22/12/2025

🧵 Essential ID Papers for 2025: A Clinician’s Guide Each year brings a flood of amazing ID literature. Here are candidates for some of the most important ID papers of 2025, spanning guidelines, trials, antimicrobials, and vaccines. 👇

picture of books, with text: "essential publications in ID, 2025 edition"

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Seth Cohen @sethalosporin.bsky.social · 24/10/2025

Love this— adding it to my teaching folder. Thanks for sharing Lisa!

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Seth Cohen @sethalosporin.bsky.social · 28/08/2025

Nice work! @drrossanarosa.bsky.social have you found a disinfectant for inpatient rooms that can be used universally regardless of colonization status or do auris rooms get their own cleaning/disinfection protocol?

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Seth Cohen @sethalosporin.bsky.social · 09/07/2025

Welcome! We’re thrilled to have you.

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Reposted by Seth Cohen

Seth Cohen @sethalosporin.bsky.social · 17/12/2024

🚨📣🚨📣 We're hiring! Open search for Associate Director of Infection Prevention at UW Medical Center Work in amazing academic environment with a phenomenal team. Fantastic quality of life. Did I mention protected time for scholarly activities? DM w q's apply.interfolio.com/160509 #IDsky

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Seth Cohen @sethalosporin.bsky.social · 17/12/2024

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Seth Cohen @sethalosporin.bsky.social · 05/12/2024

What a great match! Can’t wait to meet them.

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Seth Cohen @sethalosporin.bsky.social · 19/11/2024

Agree w all these smart people. If you have to use a phone in a patient room would treat it like a stethoscope and wipe it down after use. Would love to use LESS disposable plastic in Infection Prevention.

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Seth Cohen @sethalosporin.bsky.social · 13/11/2024

Loved this as a book and audiobook

Book cover for song of Achilles by Madeline miller

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Seth Cohen @sethalosporin.bsky.social · 12/11/2024

Your cooking looks amazing 😋

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Seth Cohen @sethalosporin.bsky.social · 12/11/2024

We use quite a few midlines. Can’t recall the last time there was a complication (hope I didn’t jinx our opat program)

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Seth Cohen @sethalosporin.bsky.social · 09/11/2024

Awesome thanks for putting this together!

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Seth Cohen @sethalosporin.bsky.social · 08/11/2024

We co-manage w breast Onc, usually doxy for 1-2 weeks (seems to be helpful in a subset of patients), repeated prn. Steroids not a large part of my practice but would consider for refractory disease. Curious about other centers experience.

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Reposted by Seth Cohen

Ilan Schwartz @germhuntermd.bsky.social · 18/10/2024

Dear IDTwitter refugees I made an #IDSky starter pack which makes it easy to find accounts of ID clinicians, medical microbiologists, ID researchers, ID epidemiologists, ID focused reporters, and of course journals ahead of the curve. Let me know if I missed you! go.bsky.app/LnAQjdq

media.tenor.com

patrick star from spongebob squarepants is standing on a sandy beach next to a black line .

ALT: patrick star from spongebob squarepants is standing on a sandy beach next to a black line .

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Seth Cohen @sethalosporin.bsky.social · 07/11/2024

Same. Really enjoyed this woodpecker next door (Seattle)

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