The mechanisms of how pH-dependent cell death, alkaliptosis, is regulated are incompletely understood. Chen et al. now demonstrate that the cholesterol biosynthesis protein CYP51A1 suppresses alkaliptosis induced by the opioid analgesic JTC801.

Recent advances in high-resolution lineage tracing technologies and single-cell genomics are allowing researchers to quantify cell state dynamics at unprecedented scales. Across cancer and immunity, …

Researchers from the Francis Crick Institute have found that some particularly aggressive lung cancer cells can develop their own electric network, like that seen in the body’s nervous system. This un...