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sebastiancachero.bsky.social

@sebastiancachero.bsky.social

Reposted by @sebastiancachero.bsky.social

Erika Dona @erikadona.bsky.social · 23/07/2026

After about a year from the preprint, our scRNAseq atlas of the developing Drosophila nerve cord has been published in @nature.com www.nature.com/articles/s41...

nature.com

A global molecular code for birth order and neuronal identity in Drosophila - Nature

A high-resolution developmental transcriptional atlas of the Drosophila melanogaster nerve cord identifies a shared transcriptional code that records neuronal birth order and organizes neuronal d...

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Reposted by @sebastiancachero.bsky.social

Daniel Gorelick @danielgorelick.bsky.social · 03/06/2026

Paying peer reviewers works. Expanded Fast & Fair experiment @biologyopen.bsky.social: • 5.5 vs 37.7 working days to decision with reviews • ~3 vs ~9 reviewer invitations per manuscript • no reduction in editor-assessed review quality • similar acceptance rates www.biorxiv.org/content/10.6...

Scatter plot showing that Fast & Fair peer review reached first decision with reviews much faster than conventional peer review: mean 5.5 versus 37.7 working days. Most Fast & Fair manuscripts met the 7-working-day target, while conventional manuscripts were slower and more variable, up to 116 working days.

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sebastiancachero.bsky.social @sebastiancachero.bsky.social · 03/09/2025

With this atlas in place, we mapped sex differences in the atlas and adult connectomes, identifying female-specific apoptosis and transcriptional divergence as drivers of sexually dimorphic development. 7/8

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sebastiancachero.bsky.social @sebastiancachero.bsky.social · 21/08/2025

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sebastiancachero.bsky.social @sebastiancachero.bsky.social · 21/08/2025

Late born neurons from each lineage form trajectories, with consecutively born neuron types arranged by birth order. By aligning 83 such trajectories, we directly compared how expression dynamics unfold across lineages. 5/8

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sebastiancachero.bsky.social @sebastiancachero.bsky.social · 21/08/2025

With unprecedented 38× coverage, our atlas resolves single neuron clusters and shows that separate waves of neurogenesis use different modes of molecular identity encoding: discrete in early born and continuous in late born. 3/8

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