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The Science of Parkinson's @scienceofpd.bsky.social · 11h

The results "further suggest that upregulation of mitophagy-related pathways may represent an adaptive mechanism to mitigate progressive mitochondrial genomic instability & preserve neuronal energy homeostasis"

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The Science of Parkinson's @scienceofpd.bsky.social · 11h

New research provides single-cell profiling of mitochondrial genomic alterations in pedunculopontine-cholinergic neurons in #Parkinsons, displaying extensive mitochondrial DNA structural disruption dominated by large-scale mitochondrial DNA deletions academic.oup.com/brain/advanc...

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The Science of Parkinson's @scienceofpd.bsky.social · 12h

An editorial summary of the research: www.nature.com/articles/s42...

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The Science of Parkinson's @scienceofpd.bsky.social · 12h

Dietary l-Arginine supplementation rescues both the MPTP & virally overexpressed mutant α-synuclein models of #Parkinsons. In addition, removing l-Arginine from the diet in both models exacerbated inflammasome activation & worsened pathology & symptoms

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The Science of Parkinson's @scienceofpd.bsky.social · 12h

Researchers screening "nutrients & metabolites" found that l-Arginine inhibits NLRP3 inflammasome assembly in vitro. It binds to the Asp31 site of the NLRP3 protein, blocking its interaction with ASC. L-Arginine levels significantly⬇️in #Parkinsons serum www.nature.com/articles/s42...

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The Science of Parkinson's @scienceofpd.bsky.social · 17h

The ARISE study randomized 341 participants (1:1:1 ratio) to once-daily solengepras 75 mg (n=114), solengepras 150 mg (n=113), or placebo (n=114) for 12 weeks Cerevance to meet with FDA to discuss the path to potential NDA

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The Science of Parkinson's @scienceofpd.bsky.social · 17h

Stat sig improvements in secondary endpoints of ON time w/o troublesome dyskinesia & motor experiences of daily living (MDS-UPDRS Part II); Improvements in daytime sleepiness (Epworth Sleepiness Scale) & quality of life (PDQ-39) point to broad motor & non-motor benefit

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The Science of Parkinson's @scienceofpd.bsky.social · 17h

Cerevance report that the high dose of Solengepras (150 mg) achieved the primary endpoint - reducing average daily OFF time by 0.61 hours vs placebo at Week 12 (p=0.0350; with benefit seen at week 2) - in their Phase 3 ARISE study in #Parkinsons www.cerevance.com/media/cereva...

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The Science of Parkinson's @scienceofpd.bsky.social · 06/10/2026

According to an autopsy study, cognitive impairment in #Parkinsons correlates with loss of cholinergic axon projections to cortex; Levels of ChAT were measured by ELISA in 8 brain regions from 37 PD autopsy cases; ChAT +tively correlated with MMSE alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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The Science of Parkinson's @scienceofpd.bsky.social · 06/10/2026

A large metabolomics study conducted on longitudinal serum samples from #Parkinsons patients (n = 632) suggests disruptions in core metabolic pathways may contribute to PD-related cognitive impairments alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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The Science of Parkinson's @scienceofpd.bsky.social · 06/10/2026

Preliminary data indicates chronic directional adaptive deep brain stimulation is feasible, tolerable, effective, & safe in people with #Parkinsons; On-time w/o troublesome dyskinesia⬆️median 1.2 hours/day; N=17 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

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The Science of Parkinson's @scienceofpd.bsky.social · 06/10/2026

Researchers report early, non-invasive "Low-intensity focused ultrasound combined with microbubbles" intervention can counteract mechanisms linked to excessive neuromelanin accumulation in a non-human primate model that overexpresses human tyrosinase academic.oup.com/brain/advanc...

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The Science of Parkinson's @scienceofpd.bsky.social · 06/10/2026

Alector grants Genentech exclusive rights to develop & commercialize AL050, an investigational GCase Enzyme Replacement Therapy (ERT) which is being developed for GBA1-associated #Parkinsons investors.alector.com/news-release...

investors.alector.com

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Participant views on return of results in the WATCH-PD qualitative study; “Will I get a chance to debrief with one of the experts that created the study at some point, or will I get a chance to see the results of the [digital] study?” journals.sagepub.com/doi/10.1177/...

journals.sagepub.com

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

By applying a heteroscedastic personalized regression framework to a #Alzheimers cohort (n=251 vs 564 controls), researchers "move beyond population-averaged risk signals to identify an internally stable, cognition-linked genetic-profile stratification" www.nature.com/articles/s44...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

By measuring dopamine & serotonin in people with #Parkinsons performing a temporal bisection task, researchers find that dopaminergic contributions to temporal cognition can be examined thru temporally resolved neurochemical signals in the human striatum academic.oup.com/brain/advanc...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

A new review on chaperone-mediated autophagy in physiological homeostasis, disease & ageing has been publisehed; #Parkinsons gets a couple of mentions, but a useful overview of the biology & potential "gerotherapeutic" targets www.nature.com/articles/s41...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

These articles (and others) are part of the Theo Murphy meeting issue ‘ProteostaSys: a systems view of proteostasis’

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

And finally: "Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease" provides a useful summary of clinicopathological correlations in human autopsy-based studies of co-pathology in neurodegenerative disease royalsocietypublishing.org/rstb/article...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Third: The microbiota–proteostasis axis: implications in neurodegenerative diseases; A model illustrating how microbiota-derived factors & gut-targeted interventions influence host proteostasis resilience across ageing & disease progression is presented royalsocietypublishing.org/rstb/article...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Next, is "Differential proteostasis imbalance & the molecular basis of distinct synucleinopathies & tauopathies" royalsocietypublishing.org/rstb/article...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

The Royal Society published a series of reviews on neurodegenerative conditions First, cellular & systemic modifiers of alpha-synuclein proteostasis; "In synucleinopathies, many different cellular processes are affected by alpha-synuclein & vice versa" royalsocietypublishing.org/rstb/article...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

The EJS ACT PD consortium presents the patient-centric development of an inclusive multi-arm multi-stage trial for #Parkinsons; Highlighting 5 challenges (& solutions) that were confronted - a monumental effort! academic.oup.com/braincomms/a...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

New data suggests that α-Synuclein seeding discriminates between LRRK2 G2019S variant carriers with & without #Parkinsons; N = 76 variant carriers (N = 22 with PD, N = 54 w/o); Seeding observed in 80% with LRRK2-PD & in 1 unaffected carrier movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

movementdisorders.onlinelibrary.wiley.com

α‐Synuclein Seeding Discriminates Between <fc>LRRK2 G2019S</fc> Variant Carriers with and Without Parkinson's Disease

Background Reliable biomarkers for Parkinson's disease (PD) pathology detection are essential for research. α-Synuclein (aSyn) seed amplification assay (SAA) is a validated biomarker for misfolded a...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

They "show that genes causally-implicated in neurodegen. disorders (NDDs) have enriched expression in peripheral immune cells, & may mediate the risk of NDDs thru regulatory effects observable in these cell types"; For SNCA, the risk of PD was associated with⬇️gene expression

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Using colocalisation & Mendelian randomisation analyses, researchers emphasize "the importance of ancestry-specific functional genetic annotations, & further suggests myeloid cells as potential targets for treatments for neurodegeneration" www.nature.com/articles/s42...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Researchers present the HandPD37 dataset, including handwriting samples from 78 #Parkinsons case & 54 healthy controls across 37 tasks, tailored for Japanese participants, enhancing the dataset’s applicability for more accurate & generalized PD detection www.nature.com/articles/s41...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

A population-based cohort study involving 2480 autopsied cases from the Biobank for Aging Studies in São Paulo (Brazil) finds 0.7% among those <50 years to 20.0% among those aged ≥90 years have Lewy body disease movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Wow! 20 years of induced pluripotent stem cells... New review explores how "the field has progressed from patient-specific disease modeling toward cell-based therapies for neurodegenerative disorders" (#Parkinsons gets highlighted) Man, I feel old... www.cell.com/cell-reports...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Researchers report that Fejerin, a peptide isolated from frog skin mucus, protective effects in both in vivo & in vitro models of #Parkinsons (via the PINK1-Parkin pathway) www.nature.com/articles/s42...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Recent studies have reported that α-synuclein undergoes phase separation to form biomolecular condensates. Now researchers find that specific #Parkinsons-associated α-synuclein variants (A30G, G51D, & A53E) fail to form them, while E46K & E83Q enhance them www.nature.com/articles/s41...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

Researchers find that astrocytic lysosomal remodeling of internalized α-syn contributes to the morphological maturation & intercellular propagation of neuronal α-syn pathology; Cathepsin D promotes α-syn processing & Lewy neurite-like aggregate maturation link.springer.com/article/10.1...

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The Science of Parkinson's @scienceofpd.bsky.social · 05/10/2026

The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann & Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.” www.nobelprize.org/prizes/medic...

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The Science of Parkinson's @scienceofpd.bsky.social · 02/10/2026

Using a novel autoantibody screening platform developed by Sengenics, researchers conducted a 2-stage case-control study to identify peripheral autoantibodies in #Parkinsons that may be useful as potential diagnostic markers www.nature.com/articles/s41...

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The Science of Parkinson's @scienceofpd.bsky.social · 02/10/2026

An editorial associated with this study: www.neurology.org/doi/10.1212/...

neurology.org

Neurology® Journals

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The Science of Parkinson's @scienceofpd.bsky.social · 02/10/2026

New research suggests that "skin denervation is closely associated with cognitive impairment in #Parkinsons & that regional brain atrophy statistically mediates this relationship"; N=155 patients with PD (PD-NC = 75; PD-MCI = 40; PDD = 40) & 50 controls www.neurology.org/doi/10.1212/...

neurology.org

Association of Skin Denervation With Brain Atrophy and Cognitive Impairment in Patients With Parkinson Disease | Neurology

Background and ObjectivesSmall fiber pathology is an intrinsic feature of Parkinson disease (PD), yet its relevance to central neurodegeneration remains unclear. Given that cognitive impairment is a m...

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The Science of Parkinson's @scienceofpd.bsky.social · 02/10/2026

Researchers "propose an updated pathophysiological model where Parkinson's tremor results from interactions between circuits that suppress (the good), initiate (the bad), & amplify (the ugly) tremor" www.sciencedirect.com/science/arti...

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The Science of Parkinson's @scienceofpd.bsky.social · 02/10/2026

"Because Omaveloxolone is also an established NRF2 activator, these in vivo benefits likely reflect dual modulation of inflammatory and antioxidant pathways"

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The Science of Parkinson's @scienceofpd.bsky.social · 02/10/2026

Researchers identify Omaveloxolone as a potent STING degrader via high-throughput screening. It binds non-covalently to the base of the STING ligand-binding domain & exhibits crowbar-like behavior consistent with STING conformational destabilization www.nature.com/articles/s41...

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

In GBA- #Parkinsons, subthalamic nucleus-deep brain stimulation treatment at later stages is associated with⬆️risk of cognitive decline. Earlier STN-DBS in GBA-PD may extend the period of improved motor function before onset of cog. decline movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

Anti-inflammatory agent dapansutrile exerts neuroprotective effects in preclinical models of #Parkinsons link.springer.com/article/10.1...

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Reposted by The Science of Parkinson's

Cure Parkinson's @cureparkinsons.org.uk · 01/10/2026

Results from Exenatide-PD3 sub-study, funded by Cure Parkinson’s, reveal a new way to predict Parkinson’s progression. Exenatide-PD3 was a phase 3 clinical trial of the Type 2 diabetes drug exenatide (Bydureon) which finished in early 2024. Find out more about the study: buff.ly/AjR8rjO

Person using a smartphone health app—tapping medical icons like a heart, stethoscope and pill—at a desk with a notebook, glasses and a cup of coffee, suggesting checking personal medical information or using telehealth tools.

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

Alternative polyadenylation plays a central part in regulation of the fate of RNA. The researchers show 3′ untranslated region choice alters SNCA mRNA localization inside cells, consistent with SNCA risk locus acting in an eQTL-independent manner in neurons & oligodendrocytes

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

Researchers present a single-cell atlas of alternative polyadenylation of the aged human brain across 2M cells from 379 human postmortem brains across individuals with & without #Alzheimers providing a cell-type-specific foundation for further analysis www.nature.com/articles/s41...

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

Interesting: Researchers introduce an organic electrochemical transistor–based multiparametric diagnostic assay that simultaneously detects total, aggregated, & serine-129–phosphorylated α-Syn proteoforms in serum L1CAM+ extracellular vesicles www.science.org/doi/10.1126/...

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

Researchers present the neuroprotective effects of AZP2006 (a PGRN/PSAP complex stabilizer) in several preclinical #Parkinsons models (in vitro & vivo), counteracting mitochondrial damage & toxicity of alpha-synuclein preformed fibril spreading journals.plos.org/plosone/arti...

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

Both elevated respiration & respiratory dysfunction increase α-syn toxicity, revealing that mitochondrial state critically affects cellular responses to α-syn; Enhancing mitochondrial biogenesis protects cells from α-syn when respiratory function is intact

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

Using yeast models, researchers find that mitochondria "are not merely downstream targets of α-synuclein pathology but active determinants of cellular vulnerability to α-synuclein stress"; Over-expression of HAP4 suppressed α-synuclein toxicity www.molbiolcell.org/doi/10.1091/...

molbiolcell.org

Distinct Mitochondrial States Modulate α-Synuclein Toxicity | Molecular Biology of the Cell

Abnormal α-synuclein (α-syn) accumulation and mitochondrial dysfunction are central features of Parkinson's disease (PD), and increasing evidence suggests that these processes are closely connected. U...

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The Science of Parkinson's @scienceofpd.bsky.social · 01/10/2026

The work provides a framework for future economic evaluations of disease-modifying therapies in #Parkinsons, recommending an individual-level state-transition (microsimulation) approach for the framework implementation

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